4-chloro-2-methylquinazoline
- CAS No.
- 6484-24-8
- Chemical Name:
- 4-chloro-2-methylquinazoline
- Synonyms
- 4-chloro-2-methylquinazoline;Quinazoline, 4-chloro-2-Methyl-;4-Chloro-2-methylquinazoline?New
- CBNumber:
- CB01078981
- Molecular Formula:
- C9H7ClN2
- Molecular Weight:
- 178.62
- MDL Number:
- MFCD05666292
- MOL File:
- 6484-24-8.mol
- MSDS File:
- SDS
| Melting point | 86-88 °C |
|---|---|
| Boiling point | 211.2±23.0 °C(Predicted) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | 1.28±0.30(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C9H7ClN2/c1-6-11-8-5-3-2-4-7(8)9(10)12-6/h2-5H,1H3 |
| InChIKey | HAAZMOAXEMIBAJ-UHFFFAOYSA-N |
| SMILES | N1=C2C(C=CC=C2)=C(Cl)N=C1C |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| HS Code | 2933599590 |
| Storage Class | 11 - Combustible Solids |
4-chloro-2-methylquinazoline price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR309403 | 4-Chloro-2-methylquinazoline >97% | 6484-24-8 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR309403 | 4-Chloro-2-methylquinazoline >97% | 6484-24-8 | 1g | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR309403 | 4-Chloro-2-methylquinazoline >97% | 6484-24-8 | 5g | $59 | 2026-06-04 | Buy |
| Apolloscientific | OR309403 | 4-Chloro-2-methylquinazoline >97% | 6484-24-8 | 25g | $274 | 2026-06-04 | Buy |
| Apolloscientific | OR309403 | 4-Chloro-2-methylquinazoline >97% | 6484-24-8 | 100g | $1091 | 2026-06-04 | Buy |
4-chloro-2-methylquinazoline Chemical Properties,Uses,Production
Uses
4-Chloro-2-methylquinazoline is primarily used as a key intermediate in pharmaceutical research and chemical biology studies, particularly in the synthesis of novel drug molecules with biological activities such as anti-tumor and antibacterial effects.
Synthesis
1769-24-0
6484-24-8
The general procedure for the synthesis of 4-chloro-2-methylquinazoline from 4-hydroxy-2-methylquinazoline was as follows: first, starting from commercially purchased 2-methylquinazolin-4(3H)-one, the chlorination reaction was carried out at the 4-position using POCl3 according to the microwave-assisted procedure as previously reported [25], which ultimately afforded 4-chloro-2-methylquinazoline in 73% yield. Subsequently, the product was applied to the synthesis of the intermediate according to the general DMAP-catalyzed procedure described in κ 3.1.3 to give molecule 37 as a beige powder in 45% yield. The melting point of the product was 118 °C (isopropanol).1H NMR (200 MHz, CDCl3) δ = 8.33 (d, J = 8 Hz, 1H), 7.95-7.83 (m, 3H), 7.65-7.56 (m, 2H), 7.42-7.25 (m, 2H), 2.59 (s, 3H), 2.47 (s, 3H).13C NMR (50 MHz, CDCl3) δ=197.9,166.3,163.7,152.0,150.9,134.3,133.3,132.0,130.1,127.1,127.0,126.0,123.8,123.4,114.3,30.1,26.2. LC-MS (ESI+) tR 4.60 min, m/z [M+H]+ 279.19. molecular weight: 278.31 g/mol. calculated value of C17H14N2O2: C, 73.37; H, 5.07; N, 10.07. measured value: C, 73.82; H, 5.11; N, 9.93.
References
[1] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 6, p. 840 - 847
[3] MedChemComm, 2013, vol. 5, # 11, p. 1700 - 1707
[4] Tetrahedron, 2014, vol. 70, # 44, p. 8257 - 8266
[5] European Journal of Medicinal Chemistry, 2016, vol. 119, p. 34 - 44
4-chloro-2-methylquinazoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Jinan Bond Chemical Technology Co., Ltd. | 86-531-88280989 | mymail1996@126.com | China | 254 | 55 |
| Shanghai Synthfine Chemical Co.,Ltd | 15921303235 | sales@synthfine.com | China | 999 | 58 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
View Lastest Price from 4-chloro-2-methylquinazoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-chloro-2-methylquinazoline
6484-24-8
|
$400.00-500.00 | 1G | 99% | 100KG | Career Henan Chemical Co |
-
- 4-chloro-2-methylquinazoline
6484-24-8
- $400.00-500.00
- 99%
- Career Henan Chemical Co
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