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ChemicalBook >> CAS DataBase List >>2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- Structure
2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- structure
CAS No.
2417987-45-0
Chemical Name:
2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-
Synonyms
GDC-6036;divarasib;GDC6036 ，E1187;GDC-6036(Divarasib);Divarasib (GDC-6036);1-((S)-4-(7-((R)-6-Amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one;2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-
CBNumber:
CB010801323
Molecular Formula:
C29H32ClF4N7O2
Molecular Weight:
622.06
MDL Number:
MOL File:
2417987-45-0.mol
MSDS File:
SDS
Last updated:2026-08-04 11:17:55
Product description Number Pack Size Price
GDC-6036 ≥98% 41852 500μg $109
GDC-6036 ≥98% 41852 1mg $207
GDC-6036 ≥98% 41852 5mg $763
GDC-6036 ≥98% 41852 10mg $1089
Divarasib 99.31% CS-0435408 1mg $325
Request For Quotation

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- Properties

Boiling point 743.4±70.0 °C(Predicted)
Density 1.344±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: Soluble: =10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml
form Solid
pka 9.13±0.40(Predicted)
color White to light yellow
FDA UNII E6S21PVT91

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 41852 GDC-6036 ≥98% 2417987-45-0 500μg $109 2026-04-30 Buy
Cayman Chemical 41852 GDC-6036 ≥98% 2417987-45-0 1mg $207 2026-04-30 Buy
Cayman Chemical 41852 GDC-6036 ≥98% 2417987-45-0 5mg $763 2026-04-30 Buy
Cayman Chemical 41852 GDC-6036 ≥98% 2417987-45-0 10mg $1089 2026-04-30 Buy
ChemScene CS-0435408 Divarasib 99.31% 2417987-45-0 1mg $325 2026-06-04 Buy
Product number Packaging Price Buy
41852 500μg $109 Buy
41852 1mg $207 Buy
41852 5mg $763 Buy
41852 10mg $1089 Buy
CS-0435408 1mg $325 Buy

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- Chemical Properties,Uses,Production

Uses

Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.

in vivo

Divarasib (10-100 mg/kg/day; PO for 7 days) decreases the ratio of free KRAS G12C[1].

Animal Model:Female C.B-17 SCID (Inbred) mice (20-21 weeks old; 24.1 g) with human NSCLC NCI-H2030.X1.1 cells[1]
Dosage:10, 25, or 100 mg/kg
Administration:Oral gavage (PO) every day (QD) for 7 days (vehicle: 0.5% methylcellulose)
Result:Decreased the ratio of free KRAS G12C to internal standard.
Dose-dependent target engagement was observed for all time points (2, 8, and 24 h post-last dose), with over 90% KRAS G12C engagement observed for the highest dose 100 mg/kg assessed.

IC 50

K-Ras(G12C): <0.01 μM (IC50)

References

[1] Lingyao Meng, et al. Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach. Anal Chem. 2022 Sep 20;94(37):12927-12933. DOI:10.1021/acs.analchem.2c03146

[2] Sushant Malhotra, et al. Fused ring compounds. WO2020097537A2.
[3] JOHN C. TRAN*, MARK MERCHANT*   Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry[J]. Analytical Chemistry, 2023, 95 11: 4834-4839. DOI: 10.1021/acs.analchem.2c04417

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- Suppliers

Global( 62)Suppliers
Supplier Tel Email Country ProdList Advantage
Nantong HI-FUTURE Biology Co., Ltd.
+86-18051384581 sales@chemhifuture.com China 3135 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32468 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10457 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +86-15965530500 nickzhang@hangyubiotech.com China 9941 58
Suzhou ARTK Medchem Co., Ltd. 		+86-18168183658 sales1@artkmedchem.com China 39021 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		+86-13382787392 sales@aeechem.com China 10002 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3504 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9863 58
Chengdu DingDang Pharmaceutical Co., Ltd. 028-86040038 market@dingdangchem.com China 1854 55
Supplier Advantage
Nantong HI-FUTURE Biology Co., Ltd.
58
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Suzhou ARTK Medchem Co., Ltd. 		58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Chengdu DingDang Pharmaceutical Co., Ltd. 55

View Lastest Price from 2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Divarasib pictures 2026-08-03 Divarasib
2417987-45-0
 $245.00-818.00 99.23% 10g TargetMol Chemicals Inc.
  • Divarasib pictures
  • Divarasib
    2417987-45-0
  • $245.00-818.00
  • 99.23%
  • TargetMol Chemicals Inc.

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- Spectrum

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-(2417987-45-0)1HNMR

2417987-45-0(2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-)Related Search:

giredestrant GDC-0623 GDC-0077 BI-2852 RMC-9805
RMC-7977 MRTX1133 BI-2493

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2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- GDC-6036(Divarasib) 1-((S)-4-(7-((R)-6-Amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one Divarasib (GDC-6036) GDC6036 ，E1187 divarasib GDC-6036 2417987-45-0 api GDC-6036