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BI-2493

BI-2493 Structure
BI-2493 structure
CAS No.
2937344-16-4
Chemical Name:
BI-2493
Synonyms
bi-2493;(S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile;(S)-2-Amino-3'-[2-[(S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile;(S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile;Spiro[1,2-benzisoxazole-7(4H),4′(5′H)-benzo[b]thiophene]-3′-carbonitrile, 2′-amino-5,6,6′,7′-tetrahydro-3-[2-[(2S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-, (4′S)-
CBNumber:
CB213613341
Molecular Formula:
C24H27N7OS
Molecular Weight:
461.58
MDL Number:
MOL File:
2937344-16-4.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
Request For Quotation

BI-2493 Properties

Boiling point 774.2±70.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka 8.62±0.40(Predicted)
form Solid
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

BI-2493 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 44474 BI-2493 ≥98% 2937344-16-4 1mg $65 2026-04-30 Buy
Cayman Chemical 44474 BI-2493 ≥98% 2937344-16-4 5mg $293 2026-04-30 Buy
Cayman Chemical 44474 BI-2493 ≥98% 2937344-16-4 10mg $520 2026-04-30 Buy
ChemScene CS-0835564 BI-2493 99.79% 2937344-16-4 1mg $704 2026-06-04 Buy
ChemScene CS-0835564 BI-2493 99.79% 2937344-16-4 5mg $1408 2026-06-04 Buy
Product number Packaging Price Buy
44474 1mg $65 Buy
44474 5mg $293 Buy
44474 10mg $520 Buy
CS-0835564 1mg $704 Buy
CS-0835564 5mg $1408 Buy

BI-2493 Chemical Properties,Uses,Production

Uses

BI-2493 is a structural analog of BI-2865 and a highly selective pan-KRAS inhibitor. This compound can attenuate tumor growth and can also be used for cancer disease research.

in vivo

BI-2493 (90 mg/kg, p.o., twice daily for 21 days) exhibits tumor-suppressive activity in LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models[1].

Animal Model:LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models
Dosage:90 mg/kg
Administration:Oral gavage (p.o.), twice daily for 21 days
Result:Reduced tumor growth in mice carrying KRAS G12C, G12D, G12V, and A146V mutation models, without causing significant toxicity to the mice.

IC 50

K-Ras WT

BI-2493 Preparation Products And Raw materials

Raw materials

Preparation Products

BI-2493 Suppliers

Global( 35)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2936 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shandong utilizing biological technology co., LTD 18669728830 15966937598 3407650895@qq.com China 5157 58
Zhengzhou Alfa Chemical Co.,Ltd +86-18530059196 sale04@alfachem.cn China 9733 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Supplier Advantage
Shanghai Tachizaki Biomedical Research Center 58
Shanghai Topbiochem Technology Co., Ltd 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Hangzhou J&H Chemical Co., Ltd. 59
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Shandong utilizing biological technology co., LTD 58
Zhengzhou Alfa Chemical Co.,Ltd 58
TargetMol Chemicals Inc. 58

View Lastest Price from BI-2493 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BI-2493 pictures 2026-07-27 BI-2493
2937344-16-4
 $538.00-1480.00 99.51% 10g TargetMol Chemicals Inc.
BI-2493 pictures 2026-06-30 BI-2493
2937344-16-4
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
BI-2493 pictures 2025-03-16 BI-2493
2937344-16-4
 5mg 98%+ HPLC HNMR 10g Hubei Chuchang Biotech Co., Ltd.
  • BI-2493 pictures
  • BI-2493
    2937344-16-4
  • $538.00-1480.00
  • 99.51%
  • TargetMol Chemicals Inc.
  • BI-2493 pictures
  • BI-2493
    2937344-16-4
  • $0.00
  • 99%
  • Shaanxi Dideu New Materials Co. Ltd
  • BI-2493 pictures
  • BI-2493
    2937344-16-4
  • 98%+ HPLC HNMR
  • Hubei Chuchang Biotech Co., Ltd.

BI-2493 Spectrum

BI-2493(2937344-16-4)1HNMR

2937344-16-4(BI-2493)Related Search:

BI-2852 RMC-9805 RMC-7977 2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- MRTX1133
BI-2865 BI-3406 Adagrasib

1of2

Spiro[1,2-benzisoxazole-7(4H),4′(5′H)-benzo[b]thiophene]-3′-carbonitrile, 2′-amino-5,6,6′,7′-tetrahydro-3-[2-[(2S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-, (4′S)- bi-2493 (S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile (S)-2-Amino-3'-[2-[(S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile (S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile 2937344-16-4