3-Amino-2,2-dimethylpropionamide
- CAS No.
- 324763-51-1
- Chemical Name:
- 3-Amino-2,2-dimethylpropionamide
- Synonyms
- Aliskiren Inter-5;3-aMino-2,2-diMethyl-;ALISKIREN InterMediates/ AM4;3-Amino-2,2-dimethylpropiomide;3-AMino-2,2-diMethylpropinaMid;3-Amino-2,2-dimethylpropanamide;3-Amino-2,2-dimethylpropionamide;PropanaMide, 3-aMino-2,2-diMethyl-;2-(aminomethyl)-2-methylpropanamide;3-amino-2,2-dimethylpropionic acid amide
- CBNumber:
- CB01094136
- Molecular Formula:
- C5H12N2O
- Molecular Weight:
- 116.16
- MDL Number:
- MFCD06797568
- MOL File:
- 324763-51-1.mol
- MSDS File:
- SDS
| Melting point | 74-75 °C |
|---|---|
| Boiling point | 271 °C |
| Density | 1.004 |
| Flash point | 117 °C |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO, Methanol |
| pka | 16.45±0.50(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C5H12N2O/c1-5(2,3-6)4(7)8/h3,6H2,1-2H3,(H2,7,8) |
| InChIKey | HKQZJXVIXAPOPZ-UHFFFAOYSA-N |
| SMILES | C(N)(=O)C(C)(C)CN |
| CAS DataBase Reference | 324763-51-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H318 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| REACH Registrations | Active |
3-Amino-2,2-dimethylpropionamide price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-A607370-2G | 3-Amino-2,2-dimethylpropanamide | 324763-51-1 | 2g | $339 | 2026-06-03 | Buy |
| TRC | TRC-A607370-1G | 3-Amino-2,2-dimethylpropanamide | 324763-51-1 | 1g | $179 | 2026-06-03 | Buy |
| TRC | TRC-A607370-100MG | 3-Amino-2,2-dimethylpropanamide | 324763-51-1 | 100mg | $65 | 2026-06-03 | Buy |
| Usbiological | 002176 | 3-Amino-2,2-dimethylpropanamide | 324763-51-1 | 100mg | $319 | 2026-06-03 | Buy |
| AstaTech | 51122 | 3-AMINO-2,2-DIMETHYLPROPANAMIDE 97% | 324763-51-1 | 0.25G | $9 | 2026-04-30 | Buy |
3-Amino-2,2-dimethylpropionamide Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
3-Amino-2,2-dimethylpropionamide is a kind of Reagent, used in the synthesis of Aliskiren.
Synthesis
7505-93-3
324763-51-1
The general procedure for the synthesis of 3-amino-2,2-dimethylpropionamide from 2-cyano-2-methylpropionamide is as follows: embodiment 5 (according to the present invention) Preparation of 3-amino-2,2-dimethylpropionamide: The product of embodiment 4 was dissolved in 840 mL of methanol-ammonia mixture (containing 169 g NH3/kg), which was subsequently transferred to an autoclave. To this was added 47.9 g of Raney Ni catalyst. The reaction mixture was stirred for hydrogenation at 60-70 °C and 5 bar hydrogen pressure for 10 hours. When analysis confirmed that the feedstock was completely consumed, the reaction mixture was filtered, the filter cake was washed with methanol, and the filtrate was subsequently evaporated to give 160 g (97% yield) of crude product. The crude product was dissolved in 800 mL of isopropanol-toluene (1:9, v/v) mixed solvent for recrystallization. Finally, 124 g (78% overall yield) of the target product 3-amino-2,2-dimethylpropionamide was obtained.
References
[1] Patent: WO2012/21446, 2012, A2. Location in patent: Page/Page column 30-31
[2] Patent: WO2010/112482, 2010, A1. Location in patent: Page/Page column 29
[3] Tetrahedron Letters, 2005, vol. 46, # 37, p. 6337 - 6340
[4] Patent: WO2011/148392, 2011, A1. Location in patent: Page/Page column 64
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 957 - 971
3-Amino-2,2-dimethylpropionamide Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing YiboYuntian Technology Co., Ltd. | 13811826434 | lichen13811826434@126.com | China | 701 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Holy Biohemdeviser Co., Ltd | 021-61551100 | China | 443 | 57 | |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
View Latest Price from 3-Amino-2,2-dimethylpropionamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 3-Amino-2,2-dimethylpropionamide
324763-51-1
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 3-Amino-2,2-dimethylpropionamide
324763-51-1
|
1kg | 98% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | 3-Amino-2,2-dimethylpropionamide
324763-51-1
|
$10.00 | 1kg | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3-Amino-2,2-dimethylpropionamide
324763-51-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Amino-2,2-dimethylpropionamide
324763-51-1
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Amino-2,2-dimethylpropionamide
324763-51-1
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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