SMZ/TMP
- CAS No.
- 8064-90-2
- Chemical Name:
- SMZ/TMP
- Synonyms
- Trimethoprim-Sulfamethoxazole;TMP-SMX;SMZ/TMP;Septrim;Chemitrim;Trimforte;Trimethoprimsulfa;Co-Trimoxazole (CTX), 95%;Sulfamethoxazole/Trimethoprim;TRIMETHOPRIM/SULPHAMETHOXAZOLE
- CBNumber:
- CB01105579
- Molecular Formula:
- C24H29N7O6S
- Molecular Weight:
- 543.6
- MDL Number:
- MOL File:
- 8064-90-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Cotrimoxazole, Ready Made Solution | A2487 | 1ml | $859 |
| Cotrimoxazole ≥98% | 30781 | 250mg | $49 |
| Cotrimoxazole ≥98% | 30781 | 500mg | $93 |
| Cotrimoxazole ≥98% | 30781 | 1g | $160 |
| Cotrimoxazole ≥98% | 30781 | 5g | $655 |
| More product size | |||
| storage temp. | -20°C |
|---|---|
| solubility | DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL,Ethanol: 0.3mg/mL |
| form | liquid |
| color | colorless to faint yellow |
| BCS Class | 4/4 |
| InChIKey | WZRJTRPJURQBRM-UHFFFAOYSA-N |
| SMILES | [S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N |
| NCI Dictionary of Cancer Terms | trimethoprim-sulfamethoxazole |
| NCI Drug Dictionary | trimethoprim-sulfamethoxazole |
| EPA Substance Registry System | Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine (8064-90-2) |
| UNSPSC Code | 51102829 |
| NACRES | NA.85 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H317-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-43 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| RTECS | UV8240000 |
| Storage Class | 12 - Non Combustible Liquids |
| Hazard Classifications | Aquatic Chronic 3 Repr. 2 |
| Hazardous Substances Data | 8064-90-2(Hazardous Substances Data) |
| Toxicity | LD50 orally in mice: 5513 mg/kg (Yamamoto) |
SMZ/TMP price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A2487 | Cotrimoxazole, Ready Made Solution | 8064-90-2 | 1ml | $859 | 2026-04-30 | Buy |
| Cayman Chemical | 30781 | Cotrimoxazole ≥98% | 8064-90-2 | 250mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 30781 | Cotrimoxazole ≥98% | 8064-90-2 | 500mg | $93 | 2026-04-30 | Buy |
| Cayman Chemical | 30781 | Cotrimoxazole ≥98% | 8064-90-2 | 1g | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 30781 | Cotrimoxazole ≥98% | 8064-90-2 | 5g | $655 | 2026-04-30 | Buy |
SMZ/TMP Chemical Properties,Uses,Production
Uses
Cotrimoxazole is an antibiotic. Pseudomonas aeruginosa has a drug resistant rate of 66% in the years 2010-2013.
World Health Organization (WHO)
The combination of sulfamethoxazole and trimethoprim (5:1) was introduced in 1971 for the treatment of a wide variety of bacterial infections. Its use has been associated with severe sensitivity reactions, many of which have been attributed to the sulphonamide component. Elderly people seem to be more vulnerable. The World Health Organization has no information further to the above concerning restrictive action taken on this combination.
Biological Activity
Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.
Side effects
Trimethoprim/sulfamethoxazole on a daily basis has a rapid onset of action
but has rare associated side effects of bone marrow suppression and toxic
epidermal necrolysis (TEN).
Nausea, vomiting, and anorexia are generally dose related.
Hypersensitivity reactions (including Stevens-Johnson syndrome and hematologic
reactions) occur in <5% of patients.
Dosage forms
One to two tablets a day. Trimethoprim is dosed at 200 mg/24 hours given either q.d. or b.i.d.
SMZ/TMP Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | offer.de@lgcgroup.com | China | 18798 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| Huai Hua Binfengchem Co., Ltd | 0745-2866851 17711757908 | 406037272@qq.com | China | 4838 | 58 |
View Lastest Price from SMZ/TMP manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Trimosulfa
8064-90-2
|
10g | TargetMol Chemicals Inc. |
-
- Trimosulfa
8064-90-2
- $0.00
- TargetMol Chemicals Inc.
