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4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide

4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide structure

CAS No.: 21312-10-7

Chemical Name:: 4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide

Synonyms: N4-ACETYLSULFAMETHOXAZOLE;STX 606;Acetylsulfisomezole;acetylsulfamethoxazole;N4-Acetylsulfisomezole;N-Acetylsulfamethoxazole;Sulfisomezole-N4-acetate;4-Acetylsulfamethoxazole;N4-Acetylsulphamethoxazole;n(sup4)-acetylsulfisomezole

CBNumber:: CB7197756

Molecular Formula:: C12H13N3O4S

Molecular Weight:: 295.31

MDL Number:: MFCD00205417

MOL File:: 21312-10-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:44

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4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide Properties

Melting point	222°C dec.
Density	1.3953 (rough estimate)
refractive index	1.6320 (estimate)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	5.60±0.50(Predicted)
form	powder
color	Light Orange to Light Brown
Water Solubility	76mg/L(37 ºC)
BRN	285801
Major Application	forensics and toxicology pharmaceutical (small molecule)
InChI	1S/C12H13N3O4S/c1-8-7-12(14-19-8)15-20(17,18)11-5-3-10(4-6-11)13-9(2)16/h3-7H,1-2H3,(H,13,16)(H,14,15)
InChIKey	GXPIUNZCALHVBA-UHFFFAOYSA-N
SMILES	O=S(NC1=NOC(C)=C1)(C2=CC=C(NC(C)=O)C=C2)=O
FDA UNII	3I1988834Q
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08,GHS07

Signal word

Danger

Hazard statements

H302-H341

Precautionary statements

P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501

WGK Germany

HS Code

29350030

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000412	Sulfamethoxazole impurity A European Pharmacopoeia (EP) Reference Standard	21312-10-7	5 mg	$241	2026-04-30	Buy
Sigma-Aldrich	PHR2578	Sulfamethoxazole impurity A	21312-10-7	30MG	$932	2026-04-30	Buy
Sigma-Aldrich	90115	N4-Acetylsulfamethoxazole analytical standard	21312-10-7	25mg	$178	2026-04-30	Buy
Sigma-Aldrich	1631511	Sulfamethoxazole Related Compound A United States Pharmacopeia (USP) Reference Standard	21312-10-7	15mg	$1390	2026-04-30	Buy
TCI Chemical	A3739	N4-Acetylsulfamethoxazole	21312-10-7	200MG	$71	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0000412	5 mg	$241	Buy
PHR2578	30MG	$932	Buy
90115	25mg	$178	Buy
1631511	15mg	$1390	Buy
A3739	200MG	$71	Buy

4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide Chemical Properties, Uses, Production

Chemical Properties

Brown Solid

Uses

A metabolite of Sulfamethoxazole.

Uses

A labelled metabolite of Sulfamethoxazole.

Definition

ChEBI: A sulfonamide compound having a 4-acetamidophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom.

Synthesis

1072-67-9

121-60-8

4-ACETYLAMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMIDE

21312-10-7

General procedure for the synthesis of N-(4-(N-(5-methylisoxazol-3-yl)aminosulfonyl)phenyl)acetamide from 3-amino-5-methylisoxazole and p-acetamidobenzenesulfonyl chloride: a mixture of 4-acetamidobenzene-1-sulfonyl chloride (4.27 mmol), 5-methylisoxazol-3-amine (4.49 mmol) and DMAP (0.21 mmol) in an anhydrous The mixture in pyridine (10 mL) was stirred at room temperature for 12 hours. After completion of the reaction, the solvent was evaporated to dryness and the residue was diluted with water and extracted with ethyl acetate. The combined organic layers were washed sequentially with water and 1 M aqueous HCl, dried over anhydrous Na2SO4, filtered and concentrated in vacuum. The resulting solid residue was purified by fast column chromatography using heptane to ethyl acetate (50-100%) gradient elution to afford the target compound N-(4-(N-(5-methylisoxazol-3-yl)aminosulfonyl)phenyl)acetamide. Yield: 59%; ESIMS m/z calculated value C12H13N3O4S [M + H]+, 296.07; measured value 296.06; 1H NMR (400 MHz, (CD3)2SO): δ 11.30 (bs, 1H), 10.35 (bs, 1H), 7.79-7.73 (m, 4H), 6.12 (s, 1H). 2.29 (s, 3H), 2.07 (s, 3H).13C NMR (100 MHz, (CD3)2SO): δ 170.71, 169.57, 158.07, 144.01, 133.36, 128.50, 119.15, 95.84, 24.57, 12.48.

References

[1] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 1, p. 12 - 17
[2] European Journal of Medicinal Chemistry, 2015, vol. 101, p. 595 - 603
[3] Shionogi Kenkyusho Nenpo, 1957, # 7, p. 301,304
[4] Chem.Abstr., 1957, p. 17889
[5] Patent: US2888455, 1957,

4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide Preparation Products And Raw materials

Raw materials

3-Amino-5-methylisoxazole N-Acetylsulfanilyl chloride

Preparation Products

Sulfamethoxazole

4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide Suppliers

Global Suppliers ( 135)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
Nanjing Dulai Biotechnology Co., Ltd.	025-84699383-8003;025-846993838003-8003 18013301590	njduly@126.com	China	3293	55
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9656	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Quality Control Solutions Ltd.	0755-66853366 13670046396	orders@qcsrm.com	China	18188	56
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9883	50
LABTER PHARMATECH(BEIJING) CO.,LTD	010-56330744 18310155299	sales@labter.com.cn	China	19999	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
Shanghai T&W Pharmaceutical Co., Ltd.	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Nanjing Dulai Biotechnology Co., Ltd.	55
Clearsynth Labs Limited	58
Bide Pharmatech Ltd.	60
Quality Control Solutions Ltd.	56
Shanghai Kewel Chemical Co., Ltd.	50
LABTER PHARMATECH(BEIJING) CO.,LTD	55

View Latest Price from 4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-17	N4-Acetylsulfamethoxazole 21312-10-7	$29.00-68.00		99.63%	10g	TargetMol Chemicals Inc.
2025-12-16	Sulfamethoxazole Impurity 21312-10-7		10mg	95	100000	Moxin Chemicals
2024-10-22	4-ACETYLAMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMIDE 21312-10-7	$17.00	1g	95%	1KG	Career Henan Chemica Co

N4-Acetylsulfamethoxazole
21312-10-7
$29.00-68.00
99.63%
TargetMol Chemicals Inc.

Sulfamethoxazole Impurity
21312-10-7
95
Moxin Chemicals

4-ACETYLAMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMIDE
21312-10-7
$17.00
95%
Career Henan Chemica Co

4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide Spectrum

4-ACETYLAMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMIDE(21312-10-7)MS 4-ACETYLAMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMIDE(21312-10-7)¹HNMR 4-ACETYLAMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMIDE(21312-10-7)¹³CNMR 4-ACETYLAMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMIDE(21312-10-7)IR1 4-ACETYLAMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMIDE(21312-10-7)IR2

21312-10-7 (4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide) Related Search:

4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide N-Acetylsulfamethoxazole-d5 Sulfacecole AURORA 23116 AURORA 10730

AURORA 10665 AURORA 22964 AURORA 10956 AURORA 23038 AURORA 10945

AURORA 11195 N-[4-(5-Methyl-isoxazol-3-ylsulfamoyl)-phenyl]-succinamic acid 2-Chloro-N-(4-([(5-methylisoxazol-3-yl)amino]sulfonyl)phenyl)acetamide N-[4-(5-Methyl-isoxazol-3-ylsulfamoyl)-phenyl]-phthalamic acid AURORA 22000

AURORA 10706 AURORA 22457 3-[4-(5-Methyl-isoxazol-3-ylsulfamoyl)-phenylcarbamoyl]-acrylic acid

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4’-((5-methyl-3-isoxazolyl)sulfamoyl)-acetanilid 4’-((5-methyl-3-isoxazolyl)sulfamoyl)acetanilide N-[3-[(5-methyl-3-isoxazolyl)sulfonylamino]phenyl]acetamide acetylsulfamethoxazole n-(4-(((5-methyl-3-isoxazolyl)amino)sulfonyl)phenyl)-acetamid n(sup4)-acetylsulfisomezole n(sup4)-acetylsulfulfamethoxazole sulfisomezole-n(sup4)-acetate N-[4-[[(5-methylisoxazol-3-yl)amino]sulphonyl]phenyl]acetamide N-Acetylsulfamethoxazole 4'-Acetyl-3-sulfa-5-methylisoxazole N-[4-[[(5-Methyl-3-isoxazolyl)amino]sulfonyl]phenyl]acetamide N4-Acetylsulfisomezole STX 606 Acetylsulfisomezole Sulfamethoxazole Impurity 1（Sulfamethoxazole EP Impurity A） Sulfisomezole-N4-acetate 4-Acetylsulfamethoxazole N-[4-[[(5-Methylisoxazol-3-yl)amino]sulfonyl]phenyl]acetamide N-4-Acetylsulphamethoxazole N4-Acetylsulphamethoxazole N-Acetyl SulfaMethoxazole-d4 (Major) SulfaMethoxazole Related CoMpound A Sulfamethoxazole EP Impurity A N-(4-(N-(5-Methylisoxazol-3-yl)sulfamoyl)phenyl)acetamide Sulfamethoxazole impurity A (EP) N⁴-Acetylsulfamethoxazole, 98% N-[4-[(5-methylisoxazol-3-yl)sulfamoyl) phenyl) acetamide(Sulfamethoxazole impurity A CRS N-[4-[(5-Methylisoxazol-3-yl)sulpha Sulfamethoxazole impurity A CRS Acetamide, N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]- N-{4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl}a cetamide Sulfamethoxazole EP Impurity A/ Sulfamethoxazole Related Compound A Sulfamethoxazole impurity A (Y0000412)Q: What is Sulfamethoxazole impurity A (Y0000412) Q: What is the CAS Number of Sulfamethoxazole impurity A (Y0000412) N-[4-[(5-Methylisoxazol-3-yl)-sulphamoyl]phenyl]acetamide Sulfamethoxazole Related Compound A (N-{4-[N-(5-methylisoxazol-3-yl)sulfamoyl]phenyl}acetamide) (1631511) Sulfamethoxazole USP Related Compound A N4-Acetylsulfamethoxazole (Sulfamethoxazole Impurity) inhibit,infection,N4Acetylsulfamethoxazole,metabolite,N4 Acetylsulfamethoxazole,Bacterial,N-4-Acetylsulfamethoxazole,sulfonamide,Inhibitor,N4-Acetylsulfamethoxazole,Acetylsulfamethoxazole N-[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]acetamide Sulfamethoxazole related compound A, EvoPure Sulfamethoxazole EP Impurity A (Sulfamethoxazole USP Related Compound A) N4-ACETYLSULFAMETHOXAZOLE 4-Acetylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide 21312-10-7 C12H13N3O4S Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Isotope Labeled Compounds