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(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL structure

CAS No.: 127733-40-8

Chemical Name:: (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL

Synonyms: S-MBT-PEM;(S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(S)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANAMINE;(S)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine;(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H;(S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-amine;(S)-ALPHA-METHYL-BIS-3,5-TRIFLUOROMETHYLBENZYLAMINE;(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL;(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethan-1-amine

CBNumber:: CB0111302

Molecular Formula:: C10H9F6N

Molecular Weight:: 257.18

MDL Number:: MFCD03093013

MOL File:: 127733-40-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:43

Product description	Number	Pack Size	Price
(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	41009	0.25G	$182
(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	41009	1G	$456
(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	41009	5G	$1596
(S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine	T897653	50mg	$130
(S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE 95.00%	HCH0014731	1G	$1033.73

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(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL Properties

Boiling point	60/14mm
Density	1.327±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	8.39±0.10(Predicted)
CAS DataBase Reference	127733-40-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi,Xn
Risk Statements	22
Hazard Note	Irritant
HS Code	2921490090

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	41009	(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	127733-40-8	0.25G	$182	2026-04-30	Buy
AstaTech	41009	(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	127733-40-8	1G	$456	2026-04-30	Buy
AstaTech	41009	(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	127733-40-8	5G	$1596	2026-04-30	Buy
TRC	T897653	(S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine	127733-40-8	50mg	$130	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0014731	(S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE 95.00%	127733-40-8	1G	$1033.73	2021-12-16	Buy

Product number	Packaging	Price	Buy
41009	0.25G	$182	Buy
41009	1G	$456	Buy
41009	5G	$1596	Buy
T897653	50mg	$130	Buy
HCH0014731	1G	$1033.73	Buy

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL Chemical Properties,Uses,Production

Uses

(R)-1-(3,5-Bis(Trifluoromethyl)phenyl)ethanamine Hydrochloride is a useful reactant for the preparation of palladium complexes with chiral pincer ligands.

Synthesis

Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-3,5-bis(trifluoromethyl)-, (αS)-

384824-41-3

Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-3,5-bis(trifluoromethyl)-, (αR)-

511256-29-4

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL

127733-40-8

127733-47-5

The general procedure for the synthesis of (S)-1 -[3,5-bis(trifluoromethyl)phenyl]ethylamine and (R)-1 -[3,5-bis(trifluoromethyl)phenyl]ethylamine, using compound (CAS:384824-41-3) and compound (CAS:511256-29-4) as raw materials, is as follows: 181 mg (0.5 mmol) of the optically active crude product of secondary amine (4a) with 18 mg (0.25 wt%) of 5% palladium/activated carbon (water content: 50 wt%) was added to 2 mL of ethanol. Subsequently, the hydrogen pressure was set to 0.2 MPa and the reaction was stirred at 55°C for 12 hours. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth, the filtrate was concentrated and dried under vacuum to afford 96 mg of the crude product, i.e., optically active 1-(3,5-bis(trifluoromethyl)phenyl)ethylamine (5a), in 75% yield. The conversion was determined to be 99% by chiral gas chromatography (GC) analysis, the selectivity of the cleavage site (a:b) was 1:99, and the optical purity of the crude product was 76% ee.

References

[1] Patent: US6797842, 2004, B2. Location in patent: Page column 19

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL Preparation Products And Raw materials

Raw materials

(RS)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE Benzene, 1-[(1S)-1-azidoethyl]-3,5-bis(trifluoromethyl)- Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-3,5-bis(trifluoromethyl)-, (αS)- Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-3,5-bis(trifluoromethyl)-, (αR)-

Ethanol Hydrogen

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Preparation Products

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL Suppliers

Global( 73)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49968	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Allfluoro pharmaceutical co. ltd.	+86-400-0216110 +86-15958047586	sales@allfluoro.com	China	11385	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
HANGZHOU LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
Allfluoro pharmaceutical co. ltd.	58

View Lastest Price from (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-11	(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL 127733-40-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2020-02-05	(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H 127733-40-8	US $3.00 / KG	1KG	98%	100KG	Career Henan Chemical Co

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL
127733-40-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H
127733-40-8
US $3.00 / KG
98%
Career Henan Chemical Co

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(S)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL (S)-ALPHA-METHYL-BIS-3,5-TRIFLUOROMETHYLBENZYLAMINE S-MBT-PEM (S)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANAMINE (S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-amine (1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride Benzenemethanamine, α-methyl-3,5-bis(trifluoromethyl)-, (αS)- (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethan-1-amine 127733-40-8 C10H9F6N