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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl structure

CAS No.: 127733-40-8

Chemical Name:: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl

Synonyms: (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-amine;S-MBT-PEM;(S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(S)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANAMINE;(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine;(S)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H;(S)-ALPHA-METHYL-BIS-3,5-TRIFLUOROMETHYLBENZYLAMINE;(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethan-1-amine;(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl

CBNumber:: CB0111302

Molecular Formula:: C10H9F6N

Molecular Weight:: 257.18

MDL Number:: MFCD03093013

MOL File:: 127733-40-8.mol

MSDS File:: SDS

Last updated:2026-09-12 18:43:53

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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl Properties

Boiling point	60/14mm
Density	1.327±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	8.39±0.10(Predicted)
CAS DataBase Reference	127733-40-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi,Xn
Risk Statements	22
Hazard Note	Irritant
HS Code	2921490090

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	41009	(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	127733-40-8	0.25G	$182	2026-04-30	Buy
AstaTech	41009	(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	127733-40-8	1G	$456	2026-04-30	Buy
AstaTech	41009	(S)-1-(3,5-BISTRIFLUOROMETHYLPHENYL)ETHYLAMINE 97%	127733-40-8	5G	$1596	2026-04-30	Buy
Apolloscientific	PC0585	(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine 97%	127733-40-8	100mg	$62	2026-06-04	Buy
Apolloscientific	PC0585	(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine 97%	127733-40-8	250mg	$98	2026-06-04	Buy

Product number	Packaging	Price	Buy
41009	0.25G	$182	Buy
41009	1G	$456	Buy
41009	5G	$1596	Buy
PC0585	100mg	$62	Buy
PC0585	250mg	$98	Buy

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl Chemical Properties, Uses, Production

Uses

(R)-1-(3,5-Bis(Trifluoromethyl)phenyl)ethanamine Hydrochloride is a useful reactant for the preparation of palladium complexes with chiral pincer ligands.

Synthesis

Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-3,5-bis(trifluoromethyl)-, (αS)-

384824-41-3

Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-3,5-bis(trifluoromethyl)-, (αR)-

511256-29-4

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL

127733-40-8

127733-47-5

The general procedure for the synthesis of (S)-1 -[3,5-bis(trifluoromethyl)phenyl]ethylamine and (R)-1 -[3,5-bis(trifluoromethyl)phenyl]ethylamine, using compound (CAS:384824-41-3) and compound (CAS:511256-29-4) as raw materials, is as follows: 181 mg (0.5 mmol) of the optically active crude product of secondary amine (4a) with 18 mg (0.25 wt%) of 5% palladium/activated carbon (water content: 50 wt%) was added to 2 mL of ethanol. Subsequently, the hydrogen pressure was set to 0.2 MPa and the reaction was stirred at 55°C for 12 hours. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth, the filtrate was concentrated and dried under vacuum to afford 96 mg of the crude product, i.e., optically active 1-(3,5-bis(trifluoromethyl)phenyl)ethylamine (5a), in 75% yield. The conversion was determined to be 99% by chiral gas chromatography (GC) analysis, the selectivity of the cleavage site (a:b) was 1:99, and the optical purity of the crude product was 76% ee.

References

[1] Patent: US6797842, 2004, B2. Location in patent: Page column 19

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl Preparation Products And Raw materials

Raw materials

(RS)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine Benzene, 1-[(1S)-1-azidoethyl]-3,5-bis(trifluoromethyl)- Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-3,5-bis(trifluoromethyl)-, (αS)- Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-3,5-bis(trifluoromethyl)-, (αR)-

Ethanol Hydrogen

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Preparation Products

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl Suppliers

Global Suppliers ( 71)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55
Shijiazhuang Lickon PharmaTech Co., Ltd.	031185291771 13832391721	yaofeng2005@163.com	China	947	58
CEG Chemical Science&Technology Co., Ltd.	Mobile:13665161512		China	1784	58
Shanghai Meishui Chemical Technology Co., Ltd	021-60549325 18616193163		China	4518	56
LABTER PHARMATECH(BEIJING) CO.,LTD	010-56330744 18310155299	sales@labter.com.cn	China	19999	55
Shanghai Qiao Chemical Science Co., Ltd	021-58892003	info@qiaochem.com	China	6065	65
TaiChem Taizhou Limited	052386810091	zcwy9518@yeah.net	China	3917	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Shanghai CR Corporation Limited	13917420128 13062833949	fred.wen@crcorporation.cn	China	9769	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Nanjing Norris-Pharm Technology Co., Ltd	55
Shijiazhuang Lickon PharmaTech Co., Ltd.	58
CEG Chemical Science&Technology Co., Ltd.	58
Shanghai Meishui Chemical Technology Co., Ltd	56
LABTER PHARMATECH(BEIJING) CO.,LTD	55
Shanghai Qiao Chemical Science Co., Ltd	65
TaiChem Taizhou Limited	58
Amadis Chemical Company Limited	58
Shanghai CR Corporation Limited	58

View Latest Price from (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-11	(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL 127733-40-8	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2020-02-05	(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H 127733-40-8	$3.00	1KG	98%	100KG	Career Henan Chemical Co

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL
127733-40-8
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H
127733-40-8
$3.00
98%
Career Henan Chemical Co

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(S)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE (S)-ALPHA-METHYL-BIS-3,5-TRIFLUOROMETHYLBENZYLAMINE S-MBT-PEM (S)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANAMINE (S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE (1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride Benzenemethanamine, α-methyl-3,5-bis(trifluoromethyl)-, (αS)- (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethan-1-amine (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-amine (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine HCl 127733-40-8 C10H9F6N