LMTK3 inibitor C28
- CAS No.
- 2764850-23-7
- Chemical Name:
- LMTK3 inibitor C28
- Synonyms
- LMTK3-IN-1;LMTK3 inibitor C28;4-{3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-yl}pyridine;6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
- CBNumber:
- CB011237183
- Molecular Formula:
- C18H11F3N4O
- Molecular Weight:
- 356.31
- MDL Number:
- MOL File:
- 2764850-23-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -10 to -25°C |
|---|---|
| solubility | Soluble to 50 mM in DMSO and to 20 mM in ethanol |
| form | Solid |
| color | Light yellow to yellow |
| InChI | 1S/C18H11F3N4O/c19-18(20,21)26-14-3-1-2-13(10-14)16-11-23-17-5-4-15(24-25(16)17)12-6-8-22-9-7-12/h1-11H |
| InChIKey | SFBZOJORTROAIE-UHFFFAOYSA-N |
| SMILES | FC(OC1=CC=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=C1)(F)F |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
LMTK3 inibitor C28 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3771 | LMTK3 inhibitor C28 ≥98% (HPLC) | 2764850-23-7 | 5mg | $175 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3771 | LMTK3 inhibitor C28 ≥98% (HPLC) | 2764850-23-7 | 25mg | $749 | 2026-04-30 | Buy |
| Cayman Chemical | 41877 | LMTK3 Inhibitor C28 ≥98% | 2764850-23-7 | 5mg | $72 | 2026-04-30 | Buy |
| Cayman Chemical | 41877 | LMTK3 Inhibitor C28 ≥98% | 2764850-23-7 | 10mg | $137 | 2026-04-30 | Buy |
| Cayman Chemical | 41877 | LMTK3 Inhibitor C28 ≥98% | 2764850-23-7 | 50mg | $572 | 2026-04-30 | Buy |
LMTK3 inibitor C28 Chemical Properties,Uses,Production
Uses
LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM[1].
Biological Activity
C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.
storage
Store at -20°C
References
[1] Agnarelli A, et al. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. Int J Mol Sci. 2023 Jan 3;24(1):865. DOI:10.3390/ijms24010865
LMTK3 inibitor C28 Preparation Products And Raw materials
Raw materials
Preparation Products
LMTK3 inibitor C28 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9796 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 10000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 955 | 58 |
View Lastest Price from LMTK3 inibitor C28 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | LMTK3-IN-1
2764850-23-7
|
$48.00-125.00 | 99.89% | 10g | TargetMol Chemicals Inc. |
-
- LMTK3-IN-1
2764850-23-7
- $48.00-125.00
- 99.89%
- TargetMol Chemicals Inc.
