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ChemicalBook >> CAS DataBase List >>(1R,4S)-N-Desmethyl Sertraline Hydrochloride

(1R,4S)-N-Desmethyl Sertraline Hydrochloride

(1R,4S)-N-Desmethyl Sertraline Hydrochloride Structure
(1R,4S)-N-Desmethyl Sertraline Hydrochloride structure
CAS No.
675126-08-6
Chemical Name:
(1R,4S)-N-Desmethyl Sertraline Hydrochloride
Synonyms
CS-2586;Dastroline;DSP-225289;Dasotraline HCl;Dastroline HCl salt;SEP-225289 hydrochloride;Sertraline Impurity 4 HCl;Sertraline Impurity 9 HCl;Sertraline Impurity 15 HCl;SEP-225289;DSP-225289;DASTROLINE
CBNumber:
CB01175303
Molecular Formula:
C16H15Cl2N.ClH
Molecular Weight:
328.66
MDL Number:
MOL File:
675126-08-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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(1R,4S)-N-Desmethyl Sertraline Hydrochloride Properties

Melting point 270-272°C (dec.)
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility Methanol (Slightly)
form Solid
color White
FDA UNII 1VIY7J4C0I

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

(1R,4S)-N-Desmethyl Sertraline Hydrochloride price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-D292105-1MG (1R,4S)-N-Desmethyl Sertraline Hydrochloride 675126-08-6 1mg $198 2026-06-03 Buy
TRC TRC-D292105-10MG (1R,4S)-N-Desmethyl Sertraline Hydrochloride 675126-08-6 10mg $1384 2026-06-03 Buy
Usbiological 008640 (1R,4S)-N-Desmethyl Sertraline Hydrochloride 675126-08-6 1mg $523 2026-06-03 Buy
Biosynth FD21320 (1R,4S)-N-Desmethyl sertraline hydrochloride 675126-08-6 10mg $251.3 2026-06-04 Buy
Biosynth FD21320 (1R,4S)-N-Desmethyl sertraline hydrochloride 675126-08-6 25mg $392.75 2026-06-04 Buy
Product number Packaging Price Buy
TRC-D292105-1MG 1mg $198 Buy
TRC-D292105-10MG 10mg $1384 Buy
008640 1mg $523 Buy
FD21320 10mg $251.3 Buy
FD21320 25mg $392.75 Buy

(1R,4S)-N-Desmethyl Sertraline Hydrochloride Chemical Properties, Uses, Production

Chemical Properties

White Solid

Uses

A metabolite of Sertraline. Used for treatment of CNS disorders.

Uses

(1R,4S)-N-Desmethyl Sertraline Hydrochloride is a metabolite of Sertraline, Used for treatment of CNS disorders.

in vivo

Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters since it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Mean dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg[2].

(1R,4S)-N-Desmethyl Sertraline Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,4S)-N-Desmethyl Sertraline Hydrochloride Suppliers

Global Suppliers ( 65)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9656 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4860 55
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
Shanghai Wishpharma Co.,Ltd. 021-56789108 18550363168 95413064@qq.com China 294 56
Artis Biotech Co. Ltd. 18108108965 18108108965 sales@artisbio.com China 2503 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Clearsynth Labs Limited 58
Bide Pharmatech Ltd. 60
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghaizehan biopharma technology co., Ltd. 55
Shanghai Wishpharma Co.,Ltd. 56
Artis Biotech Co. Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62

View Latest Price from (1R,4S)-N-Desmethyl Sertraline Hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dasotraline hydrochloride pictures 2026-07-27 Dasotraline hydrochloride
675126-08-6
 $41.00-98.00 99.96% 10g TargetMol Chemicals Inc.
(1R,4S)-N-Desmethyl Sertraline Hydrochloride pictures 2019-12-27 (1R,4S)-N-Desmethyl Sertraline Hydrochloride
675126-08-6
 $1.00 1KG 97%-99.9% 100kg Career Henan Chemical Co

(1R,4S)-N-Desmethyl Sertraline Hydrochloride Spectrum

(1R,4S)-N-Desmethyl Sertraline Hydrochloride(675126-08-6)1HNMR

675126-08-6 ((1R,4S)-N-Desmethyl Sertraline Hydrochloride) Related Search:

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VILAZODONE

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Dastroline HCl salt DSP-225289 SEP-225289;DSP-225289;DASTROLINE CS-2586 (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine Hydrochlorid (1R,4S)-N-Desmethyl Sertraline Hydrochloride (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine Hydrochloride Dastroline SEP-225289 hydrochloride (1R,4S)-N-Desmethyl sertraline HCl Sertraline Impurity 4 HCl (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride Dasotraline HCl Sertraline Impurity 15 HCl Dasotraline,Dopamine Transporter,inhibit,Dasotraline hydrochloride,Inhibitor,SERT,SEP-225289,SLC6A4,SEP 225289,5-HTT,DAT,Serotonin Transporter,SEP225289,SLC6A3 Sertraline Impurity 4 HCl （trans） Sertraline Impurity 9 HCl Dasotraline hydrochloride, 10 mM in DMSO 675126-08-6 Drug Analogues Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals