Incadronic
- CAS No.
- 124351-85-5
- Chemical Name:
- Incadronic
- Synonyms
- Incadronic;((Cycloheptylamino)methylene)diphosphonic acid;((cycloheptylamino)methylene)bis(phosphonic acid);[(cycloheptylamino)-phosphonomethyl]phosphonic acid;Phosphonic acid, P,P'-[(cycloheptylamino)methylene]bis-
- CBNumber:
- CB01178940
- Molecular Formula:
- C8H19NO6P2
- Molecular Weight:
- 287.19
- MDL Number:
- MOL File:
- 124351-85-5.mol
- MSDS File:
- SDS
| Melting point | 232-233° |
|---|---|
| Boiling point | 564.2±60.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Water (Slightly), Methanol (Slightly) |
| pka | 0.61±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | G5C4M8847E |
Incadronic price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-I499700-50MG | Incandronate | 124351-85-5 | 50mg | $709 | 2026-06-03 | Buy |
| TRC | TRC-I499700-10MG | Incandronate | 124351-85-5 | 10mg | $168 | 2026-06-03 | Buy |
| TRC | TRC-I499700-100MG | Incandronate | 124351-85-5 | 100mg | $1206 | 2026-06-03 | Buy |
| Biosynth | ZEA35185 | Incadronic acid | 124351-85-5 | 1mg | $900 | 2026-06-05 | Buy |
| Biosynth | ZEA35185 | Incadronic acid | 124351-85-5 | 10mg | $900 | 2026-06-05 | Buy |
Incadronic Chemical Properties, Uses, Production
Description
Bisphonal, a new third generation drug, was launched in Japan for the treatment of osteoporosis. It can be prepared in two steps by heating cycloheptylamine, triethylorthoformate and diethyl phosphite followed by ester hydrolysis. The mechanism of action is not well understood. Bisphonal has no effect on bone mineralization but tightly binds to calcified bone matrix and inhibits bone resorption. It causes a decrease in the number and activity of osteoclasts (morphology and decrease in H+ secretion). They seem to undergo cell death with an impairment in the process of osteoclast formation. Bisphonal does not induce osteomalacia and its activity is partly mediated through osteoblasts (releases an inhibitor of osteoclast recruitment). It is a potent inhibitor of squalene synthase (50-fold) maybe by Mg2+ chelation or as a pyrophosphate mimic, undergoes practically no metabolism, and stimulates renal production of 1,25-dihydroxyvitamin D.
Originator
Yamanouchi (Japan)
Uses
Incandronate is a bisphosphonate derivative. Bisphosphonates are most widely used as agents for treating osteoporosis and have also been used for other purposes such as herbicides, anticancer agents, and antiparasitics.
Definition
ChEBI: Incadronic acid is a 1,1-bis(phosphonic acid).
brand name
Bisphonal
Incadronic Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Pharmasea Pharmaceutical Technology (Beijing) Co., Ltd | 010-57296878 15633144420 | zhengzs2000@aliyun.com | China | 27 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 1276242629@qq.com | China | 9977 | 58 |
| Shanghai Easy CDMO Co.,Ltd | Info@easycdmo.com 13564957716 | Info@easycdmo.com | China | 9999 | 58 |
| Olix ( Hubei) Pharmaceutical Technology Co., Ltd | 17316404525 17316404525 | 209533805@qq.com | China | 9769 | 58 |
| Changzhou Xianglong Pharmaceutical Technology Co., Ltd., | 18915873328 18915873328 | sales@xianglongpharm.com | China | 11049 | 58 |
