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Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)-

Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)- structure

CAS No.: 1975146-56-5

Chemical Name:: Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)-

Synonyms: TC299423;Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)-

CBNumber:: CB011920245

Molecular Formula:: C11H15N3

Molecular Weight:: 189.26

MDL Number:

MOL File:: 1975146-56-5.mol

MSDS File:: SDS

Last updated:2026-05-11 15:21:01

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Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)- Properties

Boiling point	329.8±42.0 °C(Predicted)
Density	1.052±0.06 g/cm3(Predicted)
pka	10.27±0.40(Predicted)

Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)- Chemical Properties, Uses, Production

Description

TC299423 is a novel agonist for nicotinic acetylcholine receptors (nAChRs). TC299423 modestly selectively targets α6β2 subtype.

Uses

TC299423 is an orally active, brain-penetrant, selective and potent agonist for α6β2 and α4β2 nicotinic acetylcholine receptors (nAChRs) with anxiolytic and antinociceptive properties. TC299423 acts primarily through α6β2 nAChRs that are implicated in the anxiolytic effects of nicotine. TC299423 elicits reward-related behavior mediated through α6β2 nAChRs in hypersensitive α6L90’S mice. TC299423 elicits dopamine release and dose not suppress nicotine self-administration in rats. TC299423 is proming for rasearch of addiction and Parkinson’s disease[1][2].

References

[1] Wall TR, et al. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Front Pharmacol. 2017 Sep 26;8:641. DOI:10.3389/fphar.2017.00641
[2] Post M R. Agonist Binding Studies at Two Subtypes of the Nicotinic Acetylcholine Receptor Involved in Parkinson’s Disease and Addiction[D]. California Institute of Technology, 2016.

Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)- Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Latest Price from Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	TC299423 1975146-56-5	$1520.00-2500.00			10g	TargetMol Chemicals Inc.

TC299423
1975146-56-5
$1520.00-2500.00
TargetMol Chemicals Inc.

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Azocine, 1,2,3,4,7,8-hexahydro-5-(5-pyrimidinyl)- TC299423 1975146-56-5