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(S)-Anabasine

(S)-Anabasine structure

CAS No.: 494-52-0

Chemical Name:: (S)-Anabasine

Synonyms: Anabasin;Anabazin;3-[(2S)-piperidin-2-yl]pyridine (anabasine);ANOBASINE;ANABASINE;Neonikoti;Neonikotin;NEONICOTINE;L-ANABASINE;(-)-anabasin

CBNumber:: CB0119964

Molecular Formula:: C10H14N2

Molecular Weight:: 162.23

MDL Number:: MFCD00871391

MOL File:: 494-52-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

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(S)-Anabasine Properties

Melting point	9°C
Boiling point	270-272°C
alpha	D20 -83.1°
Density	1,0455 g/cm³
refractive index	1.5430
Flash point	93°C
storage temp.	2-8°C
solubility	DMSO : 100 mg/mL (616.41 mM)
pka	8.98±0.10(Predicted)
form	Liquid
color	Colorless to light yellow
Merck	14,619
BRN	82637
Major Application	pharmaceutical (small molecule)
InChI	1S/C10H14N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8,10,12H,1-2,5,7H2/t10-/m0/s1
InChIKey	MTXSIJUGVMTTMU-JTQLQIEISA-N
SMILES	N1[C@@H](CCCC1)c2cnccc2
CAS DataBase Reference	494-52-0(CAS DataBase Reference)
FDA UNII	LMS11II2LO
NIST Chemistry Reference	Pyridine, 3-(2-piperidinyl)-, (S)-(494-52-0)
EPA Substance Registry System	Anabasine (494-52-0)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09,GHS06
Signal word	Danger
Hazard statements	H310-H411-H300
Precautionary statements	P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501
Hazard Codes	T
Risk Statements	27/28-51/53-23/24/25
Safety Statements	28-36/37-45-61-36/37/39-28A
RIDADR	3140
WGK Germany	WGK 3
RTECS	BV4375000
HazardClass	6.1
PackingGroup	I
HS Code	29333990
Storage Class	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2 Repr. 2 Skin Irrit. 2
Hazardous Substances Data	494-52-0(Hazardous Substances Data)
Toxicity	LDLo orl-dog: 50 mg/kg JPETAB 48,95,33

(S)-Anabasine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-A637170-50MG	(S)-Anabasine (>98%) >95%(HPLC)	494-52-0	50mg	$280	2026-06-03	Buy
TRC	TRC-A637170-25MG	(S)-Anabasine (>98%) >95%(HPLC)	494-52-0	25mg	$154	2026-06-03	Buy
TRC	TRC-A637170-100MG	(S)-Anabasine (>98%) >95%(HPLC)	494-52-0	100mg	$541	2026-06-03	Buy
Biosynth	FA17898	(S)-Anabasine	494-52-0	0.05g	$211.38	2026-06-04	Buy
Biosynth	FA17898	(S)-Anabasine	494-52-0	0.1g	$365.11	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-A637170-50MG	50mg	$280	Buy
TRC-A637170-25MG	25mg	$154	Buy
TRC-A637170-100MG	100mg	$541	Buy
FA17898	0.05g	$211.38	Buy
FA17898	0.1g	$365.11	Buy

(S)-Anabasine Chemical Properties, Uses, Production

Chemical Properties

Pale Yellow Oil

Uses

(S)-ANABASINE is used as a kind of Nicotinic receptor agonist.

Uses

Anabasine occurs in the tobacco speciesNicotiana glauca, Anabasis aphylla L.,Chenopodiaceae, and Solanaceae. It is usedas an insecticide and as a metal anticorrosiveagent.

Definition

ChEBI: The (S)-enantiomer of anabasine.

Health Hazard

The acute toxic symptoms include increasedsalivation, confusion, disturbed vision, photophobia,nausea, vomiting, diarrhea, respiratorydistress, and convulsions. It causesrespiratory muscle stimulation similar to thatcaused by lobeline. An oral lethal dose indogs is 50 mg/kg. A subcutaneous lethaldose in guinea pigs is 10 mg/kg.

Biological Activity

Anabasine ((S)-Anabasine) is an alkaloid, a component of tobacco. Anabasine is a botanical insecticide that acts as a pan-agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization in TE671 cells endogenously expressing human myogenic nAChRs (EC50=0.7 μM).

Safety Profile

Poison by ingestion,subcutaneous, and intravenous routes. Moderately toxicby skin contact. An experimental teratogen. Insecticide.Acute and subacute toxicity: increased salivation, vertigo,confusion, disturbed vision and hearing, photophobia,cold ext

in vivo

Anabasine significantly reverses the impairment at the 0.2 mg/kg (p<0.05) and 2 mg/kg doses (p<0.025). Anabasine does not have any significant effects on response latency when administered alone. The 0.06 mg/kg Anabasine dose, in fact, significantly (p<0.05) exacerbates the dizocilpine-induced impairment. None of these Anabasine doses affects choice accuracy on their own. Individual dose comparisons show that the 0.06 mg/kg Anabasine dose plus dizocilpine (6.7±2.6) causes a significant (p<0.05) increase in non-response trials compare with dizocilpine alone (2.1±0.8).

(S)-Anabasine synthesis

Synthesis of (S)-Anabasine from 3-Pyridinecarboxaldehyde

(S)-Anabasine Preparation Products And Raw materials

Raw materials

(R)-3-(Piperidin-2-yl)pyridine 5-Oxo-5-(3-pyridyl)valeric acid N-tert-Butoxycarbonylanabasine 3-Pyridinecarboxaldehyde

Preparation Products

(R,S)-N-Nitrosoanabasine (S)-3-(Piperidin-2-yl)pyrdine, chlorohydrate (1:1)

(S)-Anabasine Suppliers

Global Suppliers ( 162)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Maya High Purity Chemicals	+86 (573) 82222445 (0)18006601000 452520369	sales@maya-r.com	China	11693	57
ShangHai YuanYe Biotechnology Co., Ltd.	15026964105	shyysw007@163.com	China	4998	60
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-83725681-603		China	4484	50
Beijing innoChem Science & Technology Co.,Ltd.	400-810-7969 010-59572699	ningzi.li@inno-chem.com.cn	China	6122	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
Alfa Aesar	84
Energy Chemical	61
Chemsky（shanghai）International Co.,Ltd.	50
Maya High Purity Chemicals	57
ShangHai YuanYe Biotechnology Co., Ltd.	60
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
Beijing innoChem Science & Technology Co.,Ltd.	55

View Latest Price from (S)-Anabasine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-07	(-)-ANABASINE 494-52-0	$17.00-30.00	1KG	99%	200000KG	Shaanxi Dideu Medichem Co. Ltd
2026-07-15	Anabasine 494-52-0	$73.00-129.00		99.98%	10g	TargetMol Chemicals Inc.
2023-01-12	Anabasine 494-52-0	$1.00		>99%	20tons	Anhui Rencheng Technology Co., Ltd

(-)-ANABASINE
494-52-0
$17.00-30.00
99%
Shaanxi Dideu Medichem Co. Ltd

Anabasine
494-52-0
$73.00-129.00
99.98%
TargetMol Chemicals Inc.

Anabasine
494-52-0
$1.00
>99%
Anhui Rencheng Technology Co., Ltd

(S)-Anabasine Spectrum

(-)-ANABASINE(494-52-0)¹HNMR

494-52-0 ((S)-Anabasine) Related Search:

Protionamide Sulfoxide (S)-3-(3,4,5,6-Tetrahydro-2H-[2,3']bipyridinyl-1-yl)-propionic acid methyl ester 4-Oxo-4-(S)-3,4,5,6-tetrahydro-2H-[2,3']bipyridinyl-1-yl-butyric acid (R,S)-N-Nitrosoanabasine 3-[(2S)-Piperidin-2-yl]pyridine hydrochloride

4-Methoxy-3-[(S)-1-(3,4,5,6-tetrahydro-2H-[2,3']bipyridinyl-1-yl)methyl]-benzaldehyde (S)-2-(3,4,5,6-Tetrahydro-2H-[2,3']bipyridinyl-1-yl)-ethanol (S)-Anabasine (-)-ANABASINE AKOS 213-73

(+/-)-ANABASINE DIPICRATE N-Methylanabasine (+)-Anabasinehydrochloride AKOS 213-74 ANABASINE SULFATE

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(-)-anabasin (s)-3-(2-piperidinyl)pyridine ANOBASINE L(-)-Anabasine,90% (2S)-3-(2-Piperidinyl)-pyridine (-)-2-(3'-Pyridyl)piperidine L(-)-Anabasine, 90% 500MG (S)-(-)-2-(3-PYRIDYL)PIPERIDINE (S)-1,2,3,4,5,6-HEXAHYDRO-[2,3']BIPYRIDINYL NEONICOTINE L(-)-NEONICOTINE L(-)-ANABASINE L-ANABASINE 2-(3-PYRIDYL)PIPERIDINE (-)-ANABASINE ANABASINE Nicotine USP RC G 3-(2S)-2-Piperidinyl-pyridine Neonikoti 2-(3-pyridyl)-piperidin 3-(2-Piperidinyl)pyridine 3-(2-piperidyl)-pyridin l-3-(2’-piperidyl)pyridine L-3-(2'-Piperidyl)pyridine Neonikotin Piperidine, 2-(3-pyridyl)- Pyridine, 3-(2-piperidyl)- pyridine,3-(2-pyridyl)piperidine S-(-)-Anabasine (S)-3-(Piperidin-2-yl)pyridine+ PYRIDINE,3-(2S)-2-PIPERIDINYL-, 3-((S)-piperidin-2-yl)pyridine Nicotine Related Compound G (20 mg) (S)-Anabasine, > 70% ee DISCONTINUED. Please see A637170 (S)-Anabasine, > 98% ee Nicotine Impurity G Nicotine USP Related Compound G (S)-Snabasine Anabasine in methanol Rizatriptan Impurity 3-d6 Benzoate Salt（Rizatriptan EP Impurity C-d6 Benzoate Salt） Anabasine, 10 mM in DMSO (S)-3-(Piperidin-2-yl)pyridine , Anabasine (S)-Anabasine 100 μg/mL in Acetonitrile (S)-Anabasine (>98%) 3-[(2S)-piperidin-2-yl]pyridine (anabasine) Anabasin Anabazin 494-52-0 Aromatics Compounds Aromatics Chiral Reagents Nicotine Derivatives