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ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)-

Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)-

Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- Structure
Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- structure
CAS No.
2529891-44-7
Chemical Name:
Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)-
Synonyms
EGFR-IN-59;Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)-
CBNumber:
CB012697672
Molecular Formula:
C27H23N5O4S
Molecular Weight:
513.57
MDL Number:
MOL File:
2529891-44-7.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- Properties

Boiling point 655.5±65.0 °C(Predicted)
Density 1.408±0.06 g/cm3(Predicted)
pka 5.39±0.50(Predicted)

Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- Chemical Properties, Uses, Production

Uses

EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 μM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer[1].

References

[1] Noha H Amin, et al. Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers. Bioorg Chem. 2020 Dec;105:104358. DOI:10.1016/j.bioorg.2020.104358

Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9778 55
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
EGFR-IN-59 pictures 2026-07-27 EGFR-IN-59
2529891-44-7
 $1520.00-1980.00 99.32% 10g TargetMol Chemicals Inc.
  • EGFR-IN-59 pictures
  • EGFR-IN-59
    2529891-44-7
  • $1520.00-1980.00
  • 99.32%
  • TargetMol Chemicals Inc.

2529891-44-7 (Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)-) Related Search:

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Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- EGFR-IN-59 2529891-44-7