neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-
- CAS No.
- 126050-12-2
- Chemical Name:
- neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-
- Synonyms
- neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-;L-Argininamide, L-α-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-
- CBNumber:
- CB01323993
- Molecular Formula:
- C57H68N14O10
- Molecular Weight:
- 1109.24
- MDL Number:
- MOL File:
- 126050-12-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0611508 | MEN 10207 99.80% | 126050-12-2 | 5mg | $92 | 2026-06-04 | Buy |
| ChemScene | CS-0611508 | MEN 10207 99.80% | 126050-12-2 | 10mg | $141 | 2026-06-04 | Buy |
| ChemScene | CS-0611508 | MEN 10207 99.80% | 126050-12-2 | 25mg | $282 | 2026-06-04 | Buy |
| ChemScene | CS-0611508 | MEN 10207 99.80% | 126050-12-2 | 50mg | $450 | 2026-06-04 | Buy |
| ChemScene | CS-0611508 | MEN 10207 99.80% | 126050-12-2 | 100mg | $720 | 2026-06-04 | Buy |
neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- Chemical Properties,Uses,Production
Description
MEN 10207 is a tachykinin antagonist.
Uses
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.
in vivo
but not Substance P in a dose-dependent manner. And MEN 10207 also effectively blocks the long-term reflex facilitation to the gastrocnemius nerve stimulation[1].
| Animal Model: | Decerebrate, spinalized, unanesthetized Female Sprague-Dawley rats (250-280 g)[1] |
| Dosage: | 7 pmol/10 μL, 70 pmol/10 μL, 700 pmol/10 μL |
| Administration: | Intrathecal administration; once |
| Result: | Blocked the reflex facilitation to intrathecal Neurokinin A, but not Substance P in a dose-dependent manner. |
IC 50
Tachykinin NK2 Receptor: 7.9 (pA2); NK1: 5.2 (pA2); NK3: 4.9 (pA2)
References
[1] X J Xu, et al. On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience. 1991;44(2):483-90. DOI:10.1016/0306-4522(91)90071-u
[2] P Rovero, et al. A highly selective NK-2 tachykinin receptor antagonist containing D-tryptophan. Eur J Pharmacol. 1990 Jan 3;175(1):113-5. DOI:10.1016/0014-2999(90)90161-x
[3] A K Henderson, et al. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225(2):175-8. DOI:10.1016/0922-4106(92)90099-h
neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- Preparation Products And Raw materials
Raw materials
Preparation Products
neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5037 | 58 |
| Nanjing chengqimei Biotechnology Co., Ltd | 19850819832 | 2173594524@qq.com | China | 2638 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 7446 | 58 |
| Shanghai HongTide Biotechnology Co.,Ltd. | 15318089928 | alex@hanhonggroup.com | China | 4604 | 58 |
