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N-Acetyl-L-tryptophan

N-Acetyl-L-tryptophan structure

CAS No.: 1218-34-4

Chemical Name:: N-Acetyl-L-tryptophan

Synonyms: AC-TRP-OH;Ac-L-Trp-OH;l-tryptopha;ACETYL-L-TRYPTOPHAN;N-ACETYL-TRYPTOPHAN;Ac-Try;Ace-Trp-OH;N-Ac-L-Trp;Acetyl-L-trp;AC-TRYPTOPHAN

CBNumber:: CB1259533

Molecular Formula:: C13H14N2O3

Molecular Weight:: 246.26

MDL Number:: MFCD00065976

MOL File:: 1218-34-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-25 20:17:46

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N-Acetyl-L-tryptophan Properties

Melting point	186°C
Boiling point	389.26°C (rough estimate)
alpha	+24.0~+30.0°(20℃/D)(c=1,C2H5OH)
Density	1.1855 (rough estimate)
refractive index	1.6450 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	3.65±0.10(Predicted)
form	Powder
color	White to Off-white
Stability	Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions	SKIN PROTECTING SKIN CONDITIONING
InChI	1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1
InChIKey	DZTHIGRZJZPRDV-LBPRGKRZSA-N
SMILES	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
LogP	0.702 (est)
CAS DataBase Reference	1218-34-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	U9264T8OAE
NIST Chemistry Reference	L-tryptophan, n-acetyl-(1218-34-4)
EPA Substance Registry System	L-Tryptophan, N-acetyl- (1218-34-4)
UNSPSC Code	41116107
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P280
PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	2
RTECS	YN6160000
TSCA	TSCA listed
HS Code	29339900
Storage Class	11 - Combustible Solids

N-Acetyl-L-tryptophan price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A6376	N-Acetyl-L-tryptophan	1218-34-4	10g	$85	2026-04-30	Buy
Sigma-Aldrich	A0208000	N-Acetyltryptophan European Pharmacopoeia (EP) Reference Standard	1218-34-4	125 mg	$254	2026-04-30	Buy
Sigma-Aldrich	1700523	Tryptophan Related Compound B United States Pharmacopeia (USP) Reference Standard	1218-34-4	25mg	$1380	2026-04-30	Buy
TCI Chemical	A0121	N-Acetyl-L-tryptophan >98.0%(HPLC)	1218-34-4	1g	$17	2026-04-30	Buy
TCI Chemical	A0121	N-Acetyl-L-tryptophan >98.0%(HPLC)	1218-34-4	25g	$66	2026-04-30	Buy

Product number	Packaging	Price	Buy
A6376	10g	$85	Buy
A0208000	125 mg	$254	Buy
1700523	25mg	$1380	Buy
A0121	1g	$17	Buy
A0121	25g	$66	Buy

N-Acetyl-L-tryptophan Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

N-Acetyl-L-Tryptophan, is a derivative of L-Tryptophan (T947210), that can be used as competitive inhibitor to identify and characterize tryptophanases. It can also be used as an NK1 tachykinin receptor antagonist, that may help to develop a novel therapeutic intervention for the treatment of reperfusion injury in acute ischemic stroke.

Definition

ChEBI: A N-acetyl-L-amino acid that is the N-acetyl derivative of L-tryptophan.

Biological Activity

N-Acetyl-L-tryptophan (NAT, Ac-Trp-OH) is used a substance P NK1 tachykinin receptor antagonist. N-Acetyl-L-tryptophan is also used as a competitive inhibitor to identify, differentiate and characterized tryptophanase(s).

Safety Profile

Moderately toxic by some routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOX,.

Synthesis

75-36-5

73-22-3

1218-34-4

4.1.8.4 Synthesis of N-acetyl-L-tryptophan (10b) L-tryptophan (1.00 g, 4.95 mmol) was dissolved in a mixed solution of acetone (20 mL) and 2 N NaOH (15 mL). Acetyl chloride (0.821 mL, 9.90 mmol) was added slowly and dropwise at room temperature, while 2 N NaOH was added to maintain the pH of the reaction system greater than 10. The reaction mixture was stirred at room temperature for 1 hr. Upon completion of the reaction, the acetone was removed by vacuum evaporation and the remaining aqueous phase was acidified to acidity with 3 N HCl. The aqueous phase was extracted with ethyl acetate (3 × 50 mL) and the organic phase was combined. The organic phase was washed with saturated saline and dried over anhydrous Na2SO4. The organic phase was concentrated under reduced pressure to give N-acetyl-L-tryptophan 10b (0.96 g, 80% yield) as a colorless solid.ESI/MS m/z: 246.1 [M + H]+; 1H NMR (500 MHz, DMSO) δ 12.55 (s, 1H), 10.84 (s, 1H), 8.14 (d, J = 8.0 Hz, 1H), 7.52 (d, J = 8.0 Hz, 1H), 7.33 (d, J = 8.0 Hz, 1H), 7.13 (d, J = 2.0 Hz, 1H), 7.06 (dd, J = 11.0, 4.0 Hz, 1H), 6.98 (t, J = 7.5 Hz, 1H), 4.46 (td, J = 8.5, 5.0 Hz, 1H), 3.15 (dd, J = 14.5, 5.0 Hz, 1H), 2.98 (dd, J = 14.5, 8.5 Hz, 1H), 1.80 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 6089 - 6104

N-Acetyl-L-tryptophan synthesis

Synthesis of N-Acetyl-L-tryptophan from Acetyl chloride and L-Tryptophan

N-Acetyl-L-tryptophan Preparation Products And Raw materials

Raw materials

Butanoic acid, 2-(acetylamino)-4-cyano-, methyl ester, (S)- (9CI) Nα-Acetylglutamine methyl ester 2-Propenoic acid, 2-(acetylamino)-3-(1H-indol-3-yl)-, (Z)- (2S)-2-(acetyl-nitroso-amino)-3-(1H-indol-3-yl)propanoic acid ethyl 2-acetamido-3-(1H-indol-3-yl)propanoate

ethyl (2R)-2-acetamido-3-(1H-indol-3-yl)propanoate DL-Tryptophan ethyl ester HCl N-Acetyl-D-tryptophan Thioacetic acid Acetyl chloride

Nalpha-FMOC-L-Tryptophan DL-Tryptophan L-Tryptophan

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Preparation Products

Methanol

N-Acetyl-L-tryptophan Suppliers

Global( 472)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Dahai Biomedical Co., Ltd	63811159 18906514933	sales@dahaibiochem.com	China	497	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60

Supplier	Advantage
Hangzhou Dahai Biomedical Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60

View Lastest Price from N-Acetyl-L-tryptophan manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	Ac-L-Trp-OH 1218-34-4		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-07-27	N-Acetyl-L-tryptophan 1218-34-4	$29.00		99.64%	10g	TargetMol Chemicals Inc.
2025-12-16	N-Acetyl-L-Tryptophan 1218-34-4		10mg	99%+ HPLC	1000	Moxin Chemicals

Ac-L-Trp-OH
1218-34-4
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

N-Acetyl-L-tryptophan
1218-34-4
$29.00
99.64%
TargetMol Chemicals Inc.

N-Acetyl-L-Tryptophan
1218-34-4
99%+ HPLC
Moxin Chemicals

N-Acetyl-L-tryptophan Spectrum

N-Acetyl-L-tryptophan(1218-34-4)MS N-Acetyl-L-tryptophan(1218-34-4)¹HNMR N-Acetyl-L-tryptophan(1218-34-4)¹³CNMR N-Acetyl-L-tryptophan(1218-34-4)IR1 N-Acetyl-L-tryptophan(1218-34-4)IR2

1218-34-4(N-Acetyl-L-tryptophan)Related Search:

L-5-Hydroxytryptophan Acetylacetone L-Tryptophan Acetyl coenzyme A sodium salt Acetyl chloride

N-Acetyl-L-isoleucine 2-Acetylaminopropionic acid N-Acetyl-L-asparagine N-Acetyl-L-valine 2-Acetylamino-propionic acid

N-Acetyl-D-methionine N-Acetyl-DL-aspartic acid N-Acetylneuraminic acid 5-Hydroxytryptophan N-Acetyl-L-cysteine

N-Acetyl-D-phenylalanine Ac-Ala-NH2 2-(1H-indol-3-yl)acetaldehyde

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ACETYL-L-TRYPTOPHANE AC-TRYPTOPHAN L-N-ACETYL-2-AMINO-3-(3-INDOLYL)PROPIONIC ACID (S)-2-acetaMido-3-(1H-indol-3-yl)propanoic acid Tryptophan Related CoMpound B N-Ac-Tryptohan N-ACETYL-L-TRYPTOPHAN extrapure for biochemistry (S)-2-(Acetylamino)-3-(1H-indole-3-yl)propanoic acid (S)-α-(Acetylamino)-1H-indole-3-propanoic acid 2-acetamido-3-(1H-indol-3-yl)propionic acid Ac-Trp-OH ,≥99% Tryptophan Related Compound B (25 mg) (N-Acetyl-L-Tryptophan) (2S)-2-acetaMido-3-(1H-indol-3-yl)propanoic acid Tryptophan IMpurity A N-Acetyl-L-Tryptophen N-ACETYL-L-TRYPTOPHAN:AC-TRP-OH Ace-Trp-OH N-alpha-Actetyl-L-tryptophane L-ACETYLTRYPTOPHAN H-N-ACETYL-TRP-OH RARECHEM AH BS 0070 TRYPTOPHAN, N-ACETYL- (S)-N-Acetyltryptophan Acetyl-L-trp Ac-Try L-Tryptophan, N-acetyl- n-acetyl-l-tryptopha Tryptophan, acetyl N-ACETYL-L-TRYTOPHAN N-ACETYL-L-TRYPTOPHAN N-ACETYL-TRP-OH N-ALPHA-ACETYL-L-TRYPTOPHAN N-Ac-L-Trp-OH Nα-Acetyl-L-tryptophan≥ 99.5% (HPLC) Tryptophan, N-acetyl-, L- Tryptophan Impurity 18 N-acetyl-L-pryptophn N-Acetyl-L-tryptophan > N-Acetyltryptophan CRS Tryptophan Related Compound B ( N-Acetyl-L-Tryptophan) N-Acetyl-L-tryptophan USP/EP/BP Nα-Acetyl-L-tryptophan L-N-Acetyltryptophan acetyl-laevo-tryptophan N-Ac-L-Trp N-Acetyl-L-tryptophan sodium excipient N-Acetyl-L-Tryptophan ExiPlus, Multi-Compendial, 99% N-Acetyl-L-Tryptophan extrapure, 99% Tryptophan Related Compound B (N-Acetyl-L-Tryptophan) (1700523) Tryptophan USP Related Compound B N-Acetyl-L-tryptophan, 10 mM in DMSO N-Acetyl-L-tryptophan N-Acetyltryptophan ACETYL-L-TRYPTOPHAN AC-TRP-OH Ac-L-Trp-OH l-tryptopha N-ACETYL-TRYPTOPHAN