Ro 41-5253
- CAS No.
- 144092-31-9
- Chemical Name:
- Ro 41-5253
- Synonyms
- Ro 41-5253;Ro 41-5253 >=98% (HPLC);4-[2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)
- CBNumber:
- CB01329632
- Molecular Formula:
- C28H36O5S
- Molecular Weight:
- 484.65
- MDL Number:
- MFCD00926134
- MOL File:
- 144092-31-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ro 41-5253 ≥98% (HPLC) | SML0573 | 5mg | $178 |
| Ro 41-5253 ≥98% (HPLC) | SML0573 | 25mg | $683 |
| Ro 41-5253 98.00% | orb1699478 | 1mg | $100 |
| Ro 41-5253 >98% | AA00ATCD | 5mg | $202 |
| Ro 41-5253 >98% | AA00ATCD | 10mg | $313 |
| storage temp. | -20°C |
|---|---|
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | JEIWQRITHXYGIF-LVZFUZTISA-N |
| SMILES | [S]1(=O)(=O)CCC(c2c1cc(c(c2)\C(=C\c3ccc(cc3)C(=O)O)\C)OCCCCCCC)(C)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Ro 41-5253 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0573 | Ro 41-5253 ≥98% (HPLC) | 144092-31-9 | 5mg | $178 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0573 | Ro 41-5253 ≥98% (HPLC) | 144092-31-9 | 25mg | $683 | 2026-04-30 | Buy |
| Biorbyt Ltd | orb1699478 | Ro 41-5253 98.00% | 144092-31-9 | 1mg | $100 | 2026-05-06 | Buy |
| aablocks | AA00ATCD | Ro 41-5253 >98% | 144092-31-9 | 5mg | $202 | 2026-05-28 | Buy |
| aablocks | AA00ATCD | Ro 41-5253 >98% | 144092-31-9 | 10mg | $313 | 2026-05-28 | Buy |
Ro 41-5253 Chemical Properties,Uses,Production
Description
Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.
Uses
Ro 415253 is a retinoic acid receptor antagonists, a promising starting point for antimetastatic therapies.
Definition
ChEBI: A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, w ile the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.
in vivo
Ro 41-5253 (oral gavage, 10-600 mg/kg, once a week, 4 weeks) can reduce tumor volume in female athymic Balb/mice transplanted with MCF-7 cell line[2].
| Animal Model: | Six-week-old female athymic Balb/mice transplanted with MCF-7 cell line[2] |
| Dosage: | 10, 30, 100, 300 and 600 mg/kg |
| Administration: | Oral gavage; once a week; 4 weeks |
| Result: | Resulted in a reduction in tumor volume at doses of 10, 30 and 100 mg/kg with no toxic side effects. |
References
[1] C APFEL. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89 15: 7129-7133. DOI:10.1073/pnas.89.15.7129
[2] SALVATORE TOMA. RARα antagonist RO 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines[J]. International Journal of Cancer, 1999, 78 1: 86-94. DOI:10.1002/(sici)1097-0215(19980925)78:1<86::aid-ijc14>3.0.co;2-3
Ro 41-5253 Preparation Products And Raw materials
Raw materials
Preparation Products
Ro 41-5253 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44896 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 6000 | 58 |
| Foshan Heshuo Pharm technology Co., ltd | 15363639686 | heshuoyiyao@hotmail.com | China | 2437 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
View Lastest Price from Ro 41-5253 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Ro 41-5253
144092-31-9
|
US $52.00 / mg | 98.00% | 10g | TargetMol Chemicals Inc. |
-
- Ro 41-5253
144092-31-9
- US $52.00 / mg
- 98.00%
- TargetMol Chemicals Inc.
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