4'-n-Octylbiphenyl-4-carboxylic acid
- CAS No.
- 59662-49-6
- Chemical Name:
- 4'-n-Octylbiphenyl-4-carboxylic acid
- Synonyms
- AC 55649;8BCA;AC55649,AC 55649;RARECHEM AL BO 1323;AC-55649, 10 mM in DMSO;4-(4-Octylphenyl)-benzoic acid;4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID;4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID;4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID;4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID
- CBNumber:
- CB4462046
- Molecular Formula:
- C21H26O2
- Molecular Weight:
- 310.43
- MDL Number:
- MFCD00157040
- MOL File:
- 59662-49-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 148-152 °C(Solv: dichloromethane (75-09-2)) |
|---|---|
| Boiling point | 462.0±34.0 °C(Predicted) |
| Density | 1.037±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO: >7mg/mL |
| form | solid |
| pka | 4.23±0.10(Predicted) |
| color | White to off-white |
| UNSPSC Code | 12352200 |
4'-n-Octylbiphenyl-4-carboxylic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S945579 | 4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID AldrichCPR | 59662-49-6 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | S945579 | 4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID Aldrich | 59662-49-6 | 25mg | $179 | 2024-03-01 | Buy |
| Cayman Chemical | 43166 | AC-55649 ≥95% | 59662-49-6 | 5mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 43166 | AC-55649 ≥95% | 59662-49-6 | 10mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 43166 | AC-55649 ≥95% | 59662-49-6 | 25mg | $197 | 2026-04-30 | Buy |
4'-n-Octylbiphenyl-4-carboxylic acid Chemical Properties,Uses,Production
Uses
AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).
Definition
ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.
Biological Activity
Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Biochem/physiol Actions
AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.
4'-n-Octylbiphenyl-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4'-n-Octylbiphenyl-4-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
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