Boc-Aib-OH
- CAS No.
- 30992-29-1
- Chemical Name:
- Boc-Aib-OH
- Synonyms
- 2-((tert-butoxycarbonyl)aMino)-2-Methylpropanoic acid;BOC-Aib;BOC-2-AMINOISOBUTYRIC ACID;N-BOC-2-AMINOISOBUTYRIC ACID;2-(Boc-Amino)Isobutyric Acid;N-Boc-2-aMino-2-Methylpropanoic acid;ANAM-001;tert Acid;BOC-AIB-OH;N-ALPHA-T-B
- CBNumber:
- CB0133216
- Molecular Formula:
- C9H17NO4
- Molecular Weight:
- 203.24
- MDL Number:
- MFCD00042973
- MOL File:
- 30992-29-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 118-122 °C |
|---|---|
| Boiling point | 341.54°C (rough estimate) |
| Density | 1.1886 (rough estimate) |
| refractive index | 1.4315 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Crystalline Powder |
| pka | 4.11±0.10(Predicted) |
| color | White |
| BRN | 1953772 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C9H17NO4/c1-8(2,3)14-7(13)10-9(4,5)6(11)12/h1-5H3,(H,10,13)(H,11,12) |
| InChIKey | VLHQXRIIQSTJCQ-LURJTMIESA-N |
| SMILES | C(O)(=O)[C@](C)(C)NC(OC(C)(C)C)=O |
| CAS DataBase Reference | 30992-29-1(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H290 | |||||||||
| Precautionary statements | P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29241990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Boc-Aib-OH price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.53077 | Boc-Aib-OH Novabiochem? | 30992-29-1 | 25g | $240 | 2026-04-30 | Buy |
| TCI Chemical | B3323 | 2-(tert-Butoxycarbonylamino)isobutyric Acid >98.0%(GC)(T) | 30992-29-1 | 5g | $24 | 2026-04-30 | Buy |
| TCI Chemical | B3323 | 2-(tert-Butoxycarbonylamino)isobutyric Acid >98.0%(GC)(T) | 30992-29-1 | 25g | $68 | 2026-04-30 | Buy |
| Usbiological | 264812 | Boc-a-aminoisobutyric acid Asreported | 30992-29-1 | 25g | $402 | 2026-06-03 | Buy |
| Usbiological | 264812 | Boc-a-aminoisobutyric acid Asreported | 30992-29-1 | 50g | $615 | 2026-06-03 | Buy |
Boc-Aib-OH Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Boc-α-Methylalanine is used as a catalyst in the preparation of 2-benzopyranone derivatives (isocoumarin) as well as arylbenzeneacetic acids.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
62-57-7
30992-29-1
The general procedure for the synthesis of 2-((tert-butoxycarbonyl)amino)-2-methylpropionic acid from di-tert-butyl dicarbonate and 2-aminoisobutyric acid is as follows: Preparation of Example 26: 2-(tert-butoxycarbonylamino)-2-methylpropionic acid 200 mg (1.94 mmol) of 2-amino-2-methylpropionic acid was dissolved in a solvent mixture of 8.0 mL of 1.0 N NaOH solution and 8.0 mL of 1,4-dioxane, followed by the addition of 846 mg (3.88 mmol) of di-tert-butyl dicarbonate (Boc2O). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, 1,4-dioxane was removed by distillation under reduced pressure. The residue was adjusted to pH 3 with 1N HCl solution and then extracted with 320 mL of ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 315 mg of the white solid product 2-(tert-butoxycarbonylamino)-2-methylpropanoic acid in 80% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 5.07 (brs, 1H), 1.54 (s, 6H), 1.45 (s, 9H).
References
[1] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 4, p. 1391 - 1397
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 20, p. 5679 - 5683
[3] Angew. Chem., 2018, vol. 130, p. 5781 - 5785,5
[4] Patent: US2015/210635, 2015, A1. Location in patent: Paragraph 0502-0504
[5] Patent: EP2865664, 2015, A1. Location in patent: Paragraph 0118; 0119
Boc-Aib-OH Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 1846 | 58 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 15366717810 | sales@thbiochem.com | China | 407 | 55 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| Sichuan jiayinglai technology CO.,LTD | 9018 15982359653 | 1394531348@qq.com | China | 2271 | 55 |
| Wudi Rongchuan Pharmaceutical and Chemical Technology Co., Ltd. | 021-5147-3705 17852115892 | wxj@yananpharm.com | China | 64 | 58 |
| Shan Dong FengJin Pharmaceutical Co.,Ltd. | 18364437686 18364437686 | 15066764791@163.com | China | 33 | 58 |
| Zhangjiagang Specom Biochemical Co., Ltd. | 512-0512-58992291,58992287 18606280718 | admin@spbiochem.com | China | 306 | 62 |
| Nanjing Danron Bio-New Materials Co.Ltd | 18936428028 18936428028 | 3806853067@qq.com | China | 147 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
View Lastest Price from Boc-Aib-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Boc-Aib-OH
30992-29-1
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2021-08-11 | BOC-alpha-Methylalanine
30992-29-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-02 | 2-(tert-Butoxycarbonylamino)isobutyric Acid
30992-29-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Boc-Aib-OH
30992-29-1
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- BOC-alpha-Methylalanine
30992-29-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-(tert-Butoxycarbonylamino)isobutyric Acid
30992-29-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
