Boc-Aib-OH
- CAS No.
- 30992-29-1
- Chemical Name:
- Boc-Aib-OH
- Synonyms
- 2-((tert-butoxycarbonyl)aMino)-2-Methylpropanoic acid;BOC-Aib;N-BOC-2-AMINOISOBUTYRIC ACID;2-(Boc-Amino)Isobutyric Acid;N-Boc-2-aMino-2-Methylpropanoic acid;ANAM-001;tert Acid;BOC-AIB-OH;N-ALPHA-T-B;Boc-L-Aib-OH
- CBNumber:
- CB0133216
- Molecular Formula:
- C9H17NO4
- Molecular Weight:
- 203.24
- MDL Number:
- MFCD00042973
- MOL File:
- 30992-29-1.mol
- MSDS File:
- SDS
| Melting point | 118-122 °C |
|---|---|
| Boiling point | 341.54°C (rough estimate) |
| Density | 1.1886 (rough estimate) |
| refractive index | 1.4315 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Crystalline Powder |
| pka | 4.11±0.10(Predicted) |
| color | White |
| BRN | 1953772 |
| InChI | InChI=1S/C9H17NO4/c1-8(2,3)14-7(13)10-9(4,5)6(11)12/h1-5H3,(H,10,13)(H,11,12) |
| InChIKey | VLHQXRIIQSTJCQ-LURJTMIESA-N |
| SMILES | C(O)(=O)[C@](C)(C)NC(OC(C)(C)C)=O |
| CAS DataBase Reference | 30992-29-1(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H290 | |||||||||
| Precautionary statements | P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29241990 | |||||||||
| NFPA 704 |
|
Boc-Aib-OH price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.53077 | Boc-Aib-OH Novabiochem? | 30992-29-1 | 25g | $226 | 2025-07-31 | Buy |
| TCI Chemical | B3323 | 2-(tert-Butoxycarbonylamino)isobutyric Acid >98.0%(GC)(T) | 30992-29-1 | 5g | $27 | 2025-07-31 | Buy |
| TCI Chemical | B3323 | 2-(tert-Butoxycarbonylamino)isobutyric Acid >98.0%(GC)(T) | 30992-29-1 | 25g | $76 | 2025-07-31 | Buy |
| TRC | B656940 | Boc-α-Methylalanine | 30992-29-1 | 50g | $305 | 2021-12-16 | Buy |
| TRC | B656940 | Boc-α-Methylalanine | 30992-29-1 | 10g | $120 | 2021-12-16 | Buy |
Boc-Aib-OH Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Boc-α-Methylalanine is used as a catalyst in the preparation of 2-benzopyranone derivatives (isocoumarin) as well as arylbenzeneacetic acids.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
62-57-7
30992-29-1
The general procedure for the synthesis of 2-((tert-butoxycarbonyl)amino)-2-methylpropionic acid from di-tert-butyl dicarbonate and 2-aminoisobutyric acid is as follows: Preparation of Example 26: 2-(tert-butoxycarbonylamino)-2-methylpropionic acid 200 mg (1.94 mmol) of 2-amino-2-methylpropionic acid was dissolved in a solvent mixture of 8.0 mL of 1.0 N NaOH solution and 8.0 mL of 1,4-dioxane, followed by the addition of 846 mg (3.88 mmol) of di-tert-butyl dicarbonate (Boc2O). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, 1,4-dioxane was removed by distillation under reduced pressure. The residue was adjusted to pH 3 with 1N HCl solution and then extracted with 320 mL of ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 315 mg of the white solid product 2-(tert-butoxycarbonylamino)-2-methylpropanoic acid in 80% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 5.07 (brs, 1H), 1.54 (s, 6H), 1.45 (s, 9H).
References
[1] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 4, p. 1391 - 1397
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 20, p. 5679 - 5683
[3] Angew. Chem., 2018, vol. 130, p. 5781 - 5785,5
[4] Patent: US2015/210635, 2015, A1. Location in patent: Paragraph 0502-0504
[5] Patent: EP2865664, 2015, A1. Location in patent: Paragraph 0118; 0119
Boc-Aib-OH Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8617390183901 | cynthia@enlaibio.com | China | 1100 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8826 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from Boc-Aib-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-08 | Boc-Aib-OH
30992-29-1
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2021-08-11 | BOC-alpha-Methylalanine
30992-29-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-02 | 2-(tert-Butoxycarbonylamino)isobutyric Acid
30992-29-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Boc-Aib-OH
30992-29-1
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- BOC-alpha-Methylalanine
30992-29-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-(tert-Butoxycarbonylamino)isobutyric Acid
30992-29-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
