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ARV-766

ARV-766 Structure
ARV-766 structure
CAS No.
2750830-09-0
Chemical Name:
ARV-766
Synonyms
ARV776;Luxdegalutamide;Luxdegalutamide ARV-766;4-[4-[[1-[4-[[[trans-3-(4-Cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-N-[(3S)-2,6-dioxo-3-piperidinyl]-2-fluorobenzamide
CBNumber:
CB013336286
Molecular Formula:
C45H54FN7O6
Molecular Weight:
807.95
MDL Number:
MOL File:
2750830-09-0.mol
Last updated:2025-09-23 08:43:30
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ARV-766 Properties

Boiling point 993.4±65.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
solubility DMSO: Soluble: =10 mg/ml
form Solid
pka 10.58±0.40(Predicted)
color White to off-white

ARV-766 Chemical Properties,Uses,Production

Uses

Luxdegalutamide (ARV-766) is an orally active protein hydrolysis targeted chimeric (PROTAC) targeting androgen receptor (AR), which can degrade AR resistance related mutants, including T878/H875/L702 mutants. Luxdegalutamide has anti-tumor activity and can be used in the study of castration resistant prostate cancer[1][2].

in vivo

Luxdegalutamide exhibits anti-tumor activity in mouse LNCaP and VCaP xenograft models[2].

References

[1] Snyder L, et al. In vitro evaluation of PROTAC? degrader ARV-766 for cytochrome P450-and transporter-mediated drug-drug interaction[J]. Drug Metabolism and Pharmacokinetics, 2024, 55: 100881.
[2] Snyder L, et al. Abstract ND03: Discovery of ARV-766, an androgen receptor degrading PROTAC? for the treatment of men with metastatic castration resistant prostate cancer[J]. Cancer Research, 2023, 83(7_Supplement): ND03-ND03.

ARV-766 Preparation Products And Raw materials

Raw materials

Preparation Products

ARV-766 Suppliers

Global( 48)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Chuchang Biotech Co., Ltd.
+undefined15623860702 info@chuchangbiotech.com China 202 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32433 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Shanghai Guangyang Jiali Biotechnology Co., Ltd 		13407521611 46993711@qq.com China 176 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39002 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Changzhou Borl Biotechnology Co.,LTD 13606124132;13656121842 luyan0021@163.com China 234 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5839 58
Supplier Advantage
Hubei Chuchang Biotech Co., Ltd.
58
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Aladdin Scientific 		58
Shanghai Guangyang Jiali Biotechnology Co., Ltd 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Changzhou Borl Biotechnology Co.,LTD 58
Nantong QuanYi Biotechnology Co., Ltd 58

View Lastest Price from ARV-766 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Luxdegalutamide pictures 2025-09-22 Luxdegalutamide
2750830-09-0
 US $318.00-1180.00 / mg 99.95% 10g TargetMol Chemicals Inc.
Luxdegalutamide (ARV-766) pictures 2025-03-16 Luxdegalutamide (ARV-766)
2750830-09-0
 US $0.00-0.00 / mg 5mg 98%+ HPLC HNMR 20g Hubei Chuchang Biotech Co., Ltd.
  • Luxdegalutamide pictures
  • Luxdegalutamide
    2750830-09-0
  • US $318.00-1180.00 / mg
  • 99.95%
  • TargetMol Chemicals Inc.
4-[4-[[1-[4-[[[trans-3-(4-Cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-N-[(3S)-2,6-dioxo-3-piperidinyl]-2-fluorobenzamide ARV776 Luxdegalutamide ARV-766 Luxdegalutamide 2750830-09-0