PD 122860
- CAS No.
- 122576-86-7
- Chemical Name:
- PD 122860
- Synonyms
- PD 122860;3-Pyridinecarboxylic acid, 5-cyano-1,4-dihydro-6-methyl-2-[(4-pyridinylsulfonyl)methyl]-4-[2-(trifluoromethyl)phenyl]-, ethyl ester
- CBNumber:
- CB01335783
- Molecular Formula:
- C23H20F3N3O4S
- Molecular Weight:
- 491.48
- MDL Number:
- MFCD00885556
- MOL File:
- 122576-86-7.mol
- MSDS File:
- SDS
PD 122860 Chemical Properties, Uses, Production
Description
PD 122860 is a novel dihydropyridine with sodium channel stimulating and calcium channel blocking properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the shape of the electrocardiogram T-wave. PD 122860 selectively relaxed potassium-contracted aortic rings and inhibited [3H]nitrendipine binding to rat brain membranes, suggesting that the vasodilator activity of PD 122860 is due to Ca++ channel blockade.
Uses
PD 122860 is a calcium channel blocker. PD 122860 also can stimulate sodium channel. PD 122860 can be used for the research of cardiovascular and cerebrovascular diseases[1].
References
[1] Haleen SJ, et al. PD 122860: a novel dihydropyridine with sodium channel stimulating and calcium channel blocking properties. J Pharmacol Exp Ther. 1989 Jul;250(1):22-30. PMID:2473188
PD 122860 Preparation Products And Raw materials
Raw materials
Preparation Products
PD 122860 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
