Rec 15-2739
- CAS No.
- 152735-23-4
- Chemical Name:
- Rec 15-2739
- Synonyms
- Upidosin;SB 216469;Sb 216469-s;Rec 15-2739;Unii-txg28R7G4y;Recordati 15/2739;Upidosin, 10 mM in DMSO;N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]-3-methyl-4-oxo-2-phenylchromene-8-carboxamide;4H-1-Benzopyran-8-carboxamide, N-(3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)-3-methyl-4-oxo-2-phenyl-
- CBNumber:
- CB01359752
- Molecular Formula:
- C31H33N3O4
- Molecular Weight:
- 511.61
- MDL Number:
- MOL File:
- 152735-23-4.mol
- MSDS File:
- SDS
| Boiling point | 688.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.208±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| pka | 14.40±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | TXG28R7G4Y |
Rec 15-2739 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0026991 | Upidosin 99.48% | 152735-23-4 | 5mg | $84 | 2026-06-04 | Buy |
| ChemScene | CS-0026991 | Upidosin 99.48% | 152735-23-4 | 10mg | $125 | 2026-06-04 | Buy |
| ChemScene | CS-0026991 | Upidosin 99.48% | 152735-23-4 | 25mg | $204 | 2026-06-04 | Buy |
| ChemScene | CS-0026991 | Upidosin 99.48% | 152735-23-4 | 50mg | $288 | 2026-06-04 | Buy |
| ChemScene | CS-0026991 | Upidosin 99.48% | 152735-23-4 | 100mg | $433 | 2026-06-04 | Buy |
Rec 15-2739 Chemical Properties, Uses, Production
Uses
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction[1].
in vivo
Upidosin shows greater selectivity than any other α-1 AR antagonist terazosin and tamsulosin in the anesthetized dog[1]. Upidosin (1-300 μg/kg; i.v.) is a more potent antagonist of phenylephrine mediated increases in prostatic pressure with a pA2 value of 8.74 compared to blood pressure with a pA2 value of 7.51[3].
References
[1] Leonardi A, et al. Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, part I. J Pharmacol Exp Ther. 1997 Jun;281(3):1272-83. PMID:9190863
[2] Testa R, et al. Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline-induced contraction of human prostate and mesenteric artery. J Pharmacol Exp Ther. 1996 Jun;277(3):1237-46. PMID:8667184
[3] Kenny BA, et al. Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies. Br J Pharmacol. 1996 Jun;118(4):871-8. DOI:10.1111/j.1476-5381.1996.tb15480.x
Rec 15-2739 Preparation Products And Raw materials
Raw materials
Preparation Products
Rec 15-2739 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1160 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29982 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-5885952 15955137747 | sales@aikonchem.com | China | 8012 | 58 |
