NVS-STG2
- CAS No.
- 3030588-01-0
- Chemical Name:
- NVS-STG2
- Synonyms
- NVS-STG2;NVS-STG2 New;4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid;Benzoic acid, 4-[[[4-[2-(1,1-dimethylethyl)-5,5-dimethyl-1,3-dioxan-2-yl]phenyl]methyl]amino]-3-methoxy-
- CBNumber:
- CB013887728
- Molecular Formula:
- C25H33NO5
- Molecular Weight:
- 427.53
- MDL Number:
- MOL File:
- 3030588-01-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 553.5±50.0 °C(predicted) |
|---|---|
| Density | 1.147±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 2mg/mL, clear |
| form | Solid |
| pka | 4.59±0.10(predicted) |
| color | White to off-white |
| InChIKey | CZSPKEVHLRWAFC-UHFFFAOYSA-N |
| SMILES | OC(C1=CC=C(NCC2=CC=C(C3(C(C)(C)C)OCC(C)(C)CO3)C=C2)C(OC)=C1)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
NVS-STG2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML4029 | NVS-STG2 ≥98% (HPLC) | 3030588-01-0 | 5 mg | $320 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML4029 | NVS-STG2 ≥98% (HPLC) | 3030588-01-0 | 25 mg | $1070 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML4029 | NVS-STG2 ≥98% (HPLC) | 3030588-01-0 | 1 unit | $284.05 | 2025-07-31 | Buy |
| Cayman Chemical | 40159 | NVS-STG2 ≥98% | 3030588-01-0 | 1mg | $138 | 2026-04-30 | Buy |
| Cayman Chemical | 40159 | NVS-STG2 ≥98% | 3030588-01-0 | 5mg | $310 | 2026-04-30 | Buy |
NVS-STG2 Chemical Properties, Uses, Production
Uses
NVS-STG2 is a molecular glue that targets STINGSTING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models[1][2].
Biological Activity
Potent STING allosteric agonist th at induces a STING-mediated immune responses in cells.
NVS-STG2 is a potent STING (stimulator of interferon genes) allosteric agonist (AC=5.2 μM) th at induces a STING-mediated immune responses in cells. It elicits potent antitumor activity in animal models. NVS-STG2 acts as molecular glue th at binds the transmembrane domains of the neighboring STING dimers.
in vivo
NVS-STG2 (800 μg; intratumoral injection; 3 times; days 11, 14, and 18) can significantly slow tumor growth in the MC38 tumor model of hSTING gene knock-in mice[1].
NVS-STG2 (400 μg, 800 μg; intratumoral injection; 1 time; day 8) can induce significant dose-dependent T cell priming responses in the B16-SIY tumor model of hSTING gene knock-in mice[1].
| Animal Model: | Female C57BL/6 wild-type and hSTING knock-in mice (10-12 weeks old, 20-25 g) with MC38 flank tumors and B16-SIY flank tumors[1] |
| Dosage: | 800 μg, 400 μg (not specified in the article about the solvent) |
| Administration: | For the MC38 tumor model, intratumoral injection, 3 times, on days 11, 14, and 18. For the B16-SIY tumor model, intratumoral injection, single dose, on day 8 |
| Result: | In the MC38 tumor model, slowed tumor growth significantly, and resulted in no significant tumor growth among 4/9 mouse during the 33-day experimental period. In the B16-SIY tumor model, exhibited a dose-dependent and significant induction of T-cell priming response. Resulted a significant increase in plasma IFNγ level at 6 h after dosing. |
References
[1] Li J et al. Activation of human STING by a molecular glue-like compound. Nat Chem Biol. 2023 Oct 12. DOI:10.1038/s41589-023-01434-y
[2] Sulpizio A, et al. A new road to STING activation. Nat Chem Biol. 2023 Oct 13. DOI:10.1038/s41589-023-01455-7
NVS-STG2 Preparation Products And Raw materials
Raw materials
Preparation Products
NVS-STG2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Soochow Chirally Material Science and Technology Co.,Ltd | 0512-66834346 17751187418 | sales@krl-tech.com | China | 1283 | 58 |
| Tianjin Jiayi Biotechnology Co., LTD | 13261917876 13261917876 | 503591062@qq.com | China | 495 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 9995 | 58 |
| Henan Mengtai Pharmaceutical Technology Co., Ltd | 17634413542 | 1959525201@qq.com | China | 9011 | 58 |
| Shanghai Anbida Biotechnology Co., Ltd. | 021-61629020 18201956406 | sales@ambeed.cn | China | 7032 | 58 |
