4,5-Dichloro-2-nitrophenol
- CAS No.
- 39224-65-2
- Chemical Name:
- 4,5-Dichloro-2-nitrophenol
- Synonyms
- ,5-Dichloro-2-nitrophenol;Phenol, 4,5-dichloro-2-nitro-;4,5-Dichloro-2-nitrophenol 98%
- CBNumber:
- CB01419744
- Molecular Formula:
- C6H3Cl2NO3
- Molecular Weight:
- 208
- MDL Number:
- MFCD09836170
- MOL File:
- 39224-65-2.mol
- MSDS File:
- SDS
| Melting point | 82-82.5℃ |
|---|---|
| Boiling point | 274.0±35.0 °C(Predicted) |
| Density | 1.682±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | crystalline solid |
| pka | 5.31±0.27(Predicted) |
| color | Lemon / yellow |
| InChI | InChI=1S/C6H3Cl2NO3/c7-3-1-5(9(11)12)6(10)2-4(3)8/h1-2,10H |
| InChIKey | CEFFUJIHZMPDID-UHFFFAOYSA-N |
| SMILES | C1(O)=CC(Cl)=C(Cl)C=C1[N+]([O-])=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P280 |
| HS Code | 2908990000 |
4,5-Dichloro-2-nitrophenol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | PBA22465 | 5-Dichloro-2-nitrophenol | 39224-65-2 | 10g | $354 | 2026-06-04 | Buy |
| Activate Scientific | AS47543 | 4,5-Dichloro-2-nitrophenol 97% | 39224-65-2 | 1g | $35 | 2026-06-04 | Buy |
| Activate Scientific | AS47543 | 4,5-Dichloro-2-nitrophenol 97% | 39224-65-2 | 5g | $152 | 2026-06-04 | Buy |
| Activate Scientific | AS47543 | 4,5-Dichloro-2-nitrophenol 97% | 39224-65-2 | 25g | $670 | 2026-06-04 | Buy |
| Matrix Scientific | 084591 | 4,5-Dichloro-2-nitrophenol | 39224-65-2 | 1.00g | $561 | 2026-05-18 | Buy |
4,5-Dichloro-2-nitrophenol Chemical Properties, Uses, Production
Uses
4,5-Dichloro-2-nitrophenol is used in the synthesis of dimethylpropanthioates as CETP inhibitors. Also used in the improved synthesis of hydroxyindoles.
Synthesis
95-77-2
39224-65-2
General procedure for the synthesis of 4,5-dichloro-2-nitrophenol from 3,4-dichlorophenol: 3,4-dichlorophenol (30 g, 185 mmol) was dissolved in dichloromethane (DCM, 300 mL) at -15 °C, followed by the addition of sulfuric acid (24 g, 278 mmol). Nitric acid (19 g, 194 mmol) was slowly added dropwise at a temperature maintained at -15 °C to -5 °C for a controlled time of 20 min or more. After the dropwise addition, the reaction mixture was continued to be stirred at 0 °C for 1 hour. After completion of the reaction, the mixture was poured into ice water and extracted with ethyl acetate. The organic layers were combined and washed sequentially with water, saturated aqueous sodium bicarbonate (NaHCO3) and brine, and then dried over anhydrous sodium sulfate (Na2SO4). The dried organic phase was concentrated under reduced pressure, and the resulting residue was purified by rapid column chromatography on silica gel (eluent ratio of petroleum ether/ethyl acetate = 100:1) to give the target product 4,5-dichloro-2-nitrophenol (16 g, 42% yield) as a solid.
References
[1] Patent: US2014/288045, 2014, A1. Location in patent: Paragraph 0455
[2] Synthesis, 2004, # 18, p. 3043 - 3046
[3] Journal of Organic Chemistry, 1996, vol. 61, # 10, p. 3289 - 3297
[4] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 81
[5] European Journal of Medicinal Chemistry, 2012, vol. 56, p. 108 - 119
4,5-Dichloro-2-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zhixia Chemical Technology Co., LTD | 15216847143 18321145570 | 1458509898@qq.com | China | 499 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Nanjing ShengSai Chemical Co., Ltd. | 025-85205967 13951876367 | shengsaichem@163.com | China | 818 | 58 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Beijing Wuyunyongchang Science and Technology Co., Ltd. | 15210642910 | moon5.1days@126.com | China | 202 | 56 |
