WYJ-2
- CAS No.
- 3029403-05-9
- Chemical Name:
- WYJ-2
- Synonyms
- WYJ-2;1,2,4-Oxadiazole, 3-(6-fluoro-2H-1-benzopyran-3-yl)-5-(2-fluoro-5-nitrophenyl)-
- CBNumber:
- CB014296462
- Molecular Formula:
- C17H9F2N3O4
- Molecular Weight:
- 357.27
- MDL Number:
- MOL File:
- 3029403-05-9.mol
WYJ-2 Chemical Properties,Uses,Production
Uses
WYJ-2 is a selective agonist for toll-like receptor 2/1 (TLR2/1) with EC50 of 18.57 nM in human TLR2 and TLR1 transient-cotransfected HEK 293T cells. WYJ-2 induces pyroptosis and exhibits anticancer activity against non-small cell lung cancer (NSCLC)[1].
in vivo
WYJ-2 (5 mg/kg, i.p. every teo days for 30 days) inhibits tumor growth without significant toxicity in A549 xenograft BALB/c mice[1].
WYJ-2 (10 mg/kg, i.p.) exhibits a pharmacokinetic profil with half-time of T1/2 of 3.67 h and a clearance Cmax of 497 ± 49 ng/mL[1].
| Animal Model: | A549 xenograft BALB/c mice[1] |
| Dosage: | 5 mg/kg |
| Administration: | i.p. every two days for 30 days |
| Result: | Inhibited tumor growth with a TGI of 72.22% without significant loss of body weight. |
IC 50
TLR2
References
[1] Wang Y, et al., Design and Synthesis of 3-(2H-Chromen-3-yl)-5-aryl-1,2,4-oxadiazole Derivatives as Novel Toll-like Receptor 2/1 Agonists That Inhibit Lung Cancer In Vitro and In Vivo. J Med Chem. 2024 Mar 18. DOI:10.1021/acs.jmedchem.3c01984
WYJ-2 Preparation Products And Raw materials
Raw materials
Preparation Products
WYJ-2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
