Sofalcone
- CAS No.
- 64506-49-6
- Chemical Name:
- Sofalcone
- Synonyms
- solon;isoprenylchalcone;su88;Sofacone;SOFALCONE;SOFALCONE JP;(E)-Sofalcone;Mr. Method ketone;Sofalcone USP/EP/BP;Sofalcone (Standard)
- CBNumber:
- CB0143037
- Molecular Formula:
- C27H30O6
- Molecular Weight:
- 450.52
- MDL Number:
- MFCD00868207
- MOL File:
- 64506-49-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 143-144° |
|---|---|
| Boiling point | 478.6°C (rough estimate) |
| Density | 1.1362 (rough estimate) |
| refractive index | 1.4870 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 2.98±0.10(Predicted) |
| color | Light Yellow |
| InChI | InChI=1S/C27H30O6/c1-19(2)13-15-31-22-8-5-21(6-9-22)7-12-25(28)24-11-10-23(32-16-14-20(3)4)17-26(24)33-18-27(29)30/h5-14,17H,15-16,18H2,1-4H3,(H,29,30) |
| InChIKey | GFWRVVCDTLRWPK-UHFFFAOYSA-N |
| SMILES | C(O)(=O)COC1=CC(OC/C=C(\C)/C)=CC=C1C(=O)C=CC1=CC=C(OC/C=C(\C)/C)C=C1 |
| CAS DataBase Reference | 64506-49-6(CAS DataBase Reference) |
| FDA UNII | 2B668TJX8E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Toxicity | LD50 in mice, rats: >10 g/kg orally (Tarumoto) | |||||||||
| NFPA 704 |
|
Sofalcone price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3730 | Sofalcone | 64506-49-6 | 5G | $56 | 2026-04-30 | Buy |
| TCI Chemical | M3730 | Sofalcone | 64506-49-6 | 25G | $196 | 2026-04-30 | Buy |
| Cayman Chemical | 11882 | Sofalcone ≥98% | 64506-49-6 | 100mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 11882 | Sofalcone ≥98% | 64506-49-6 | 250mg | $127 | 2026-04-30 | Buy |
| Cayman Chemical | 11882 | Sofalcone ≥98% | 64506-49-6 | 500mg | $238 | 2026-04-30 | Buy |
Sofalcone Chemical Properties, Uses, Production
Pharmacological action
Sofalcone is an effective component extracted and synthesized from traditional Chinese medicine Sophora tonkinensis. It is the product of isoprene derivatives. It can increase gastric blood flow, expand gastric mucosal blood vessels, increase oxygen consumption in gastric tissue, promote gastric mucosal repair, increase gastric wall composition and increase prostaglandin content in gastric tissue. Its mechanism is to inhibit prostaglandin 5hydroxyl prostaglandin dehydrogenase (PG). This product has a good effect on the ulcer of the digestive tract by enhancing the defense factor. It is mainly used for the treatment of gastric ulcer and gastritis.
Figure 1 Structural formula for sofalcone
Pharmacokinetics
This product is absorbed quickly after oral administration, and the concentration is up to the peak in about one hour. The half life of plasma is about 1h, and it will almost disappear in the blood after 2h. The main metabolites in the body are the reductive products of the alpha and beta unsaturated bonds of the chalcone skeleton, and the oxidation products of the isoprene side chain. It is excreted from urine by 6% to 8% in the form of isoprene chain oxidation products within 48h.
Description
Sofalcone is a synthetic antiulcer agent related to sophoradin, the active principle of the Chinese medicinal plant, Sophora subprostata. It is suggested to act via a strengthening of the mucosal barrier through an increase in blood flow and stimulation of the synthesis of sulfated mucopolysaccharides.
Originator
Japan (Japan)
Uses
Sofalcone is a substituted chalcone with anti-ulcer activity.
Uses
Sofalcone is an anti-ulcer chalcone derivative. It blocks inflammation by suppressing the production of nitric oxide, TNF-α, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 μM. Sofalcone (20-50 μM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.[Cayman Chemical]
Definition
ChEBI: Sofalcone is a member of the class of chalcones that is benzene in which the hydrogens at positions 1,2 and 5 are replaced by carboxymethoxy, (1E)-1-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-oxoprop-1-en-3-yl, and (3-methylbut-2-en-1-yl)oxy groups, respectively. It is a gastrointestinal drug currently used for treatment of gastritis and gastric ulcers in Japan and South Korea. It has a role as an anti-ulcer drug, a gastrointestinal drug, a plant metabolite and an antibacterial agent. It is an aromatic ether, a monocarboxylic acid and a member of chalcones.
Sofalcone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Kai Rui Pharmaceutical Co., Ltd. | -- | China | 5 | 60 | |
| Taizhou Jiecheng Chemical Co., Ltd. | 15868606025 | 2598306141@qq.com | China | 100 | 55 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wujiang Suke Medical Technology Co., Ltd. | +86-512-6320-2019 | China | 28 | 60 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Moltt Biocem Co., Ltd. | +86-21-38682181 15900741819 | China | 281 | 55 |
View Latest Price from Sofalcone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-14 | Sofalcone
64506-49-6
|
1kg | 99% | 20tons | Sinoway Industrial co., ltd. | ||
 |
2026-04-20 | Sofalcone
64506-49-6
|
$48.00-81.00 | 99.40% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-10-29 | Sofalcone
64506-49-6
|
$50.00-100.00 | 1kg | 99 | Hebei Shengyuan Jinlong Import and Export Co. LTD |
