Desogestrel
- CAS No.
- 54024-22-5
- Chemical Name:
- Desogestrel
- Synonyms
- Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL
- CBNumber:
- CB2359630
- Molecular Formula:
- C22H30O
- Molecular Weight:
- 310.47
- MDL Number:
- MFCD00869346
- MOL File:
- 54024-22-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 109-110°C |
|---|---|
| alpha | D20 +55° (chloroform) |
| Boiling point | 390.62°C (rough estimate) |
| Density | 1.0169 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride. |
| pka | 13.07±0.40(Predicted) |
| form | Solid |
| color | White to Almost white |
| Merck | 14,2926 |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3 |
| InChIKey | RPLCPCMSCLEKRS-UHFFFAOYSA-N |
| SMILES | C1C2C(CCC3C2C(=C)CC2(CC)C3CCC2(C#C)O)=CCC1 |
| FDA UNII | 81K9V7M3A3 |
| NCI Drug Dictionary | Cerazette |
| ATC code | G03AC09 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H410 |
| Precautionary statements | P202-P273-P280-P308+P313-P391-P405 |
| Safety Statements | 24/25 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | JF7975000 |
| HS Code | 29372390 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Repr. 1B |
| Hazardous Substances Data | 54024-22-5(Hazardous Substances Data) |
Desogestrel price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000510 | Desogestrel for system suitability European Pharmacopoeia (EP) Reference Standard | 54024-22-5 | 10 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000509 | Desogestrel European Pharmacopoeia (EP) Reference Standard | 54024-22-5 | 60 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1173235 | Desogestrel United States Pharmacopeia (USP) Reference Standard | 54024-22-5 | 100mg | $455 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000509 | Desogestrel European Pharmacopoeia (EP) Reference Standard | 54024-22-5 | 50 mg | $156 | 2025-07-31 | Buy |
| Sigma-Aldrich | 32809 | Desogestrel VETRANAL | 54024-22-5 | 25mg | $164 | 2022-05-15 | Buy |
Desogestrel Chemical Properties, Uses, Production
Description
Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.
Chemical Properties
White Solid
Originator
Dicromil,Organol ,W. Germany,1981
Uses
A progestogen with low androgenic potency
Definition
ChEBI: Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.
Manufacturing Process
A solution of 1.0 g of 11,11-methylene-18-methyl-delta4-estren-17-one in 33
ml tetrahydrofuran was added to a potassium-acetylide solution in
tetrahydrofuran.
After 2 hours of stirring at 0°C to 5°C the reaction mixture was acidified with
2N H2SO4and processed further.
By a chromatographic treatment on silica gel and crystallization from pentane
0.7 g of 11,11-methylene-17α-ethynyl-18-methyl-δ4-estren-17β-ol with a
melting point of 109°C to 110°C and an [α]D of +55°C (CHCl3) was obtained.
Therapeutic Function
Progestin
General Description
Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.
Clinical Use
Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.
References
[1] J VAN DER VIES J de V. Endocrinological studies with desogestrel.[J]. Arzneimittel-Forschung-Drug Research, 1983, 33 2: 231-236.
[2] MARGIT FRHLICH. In vitro and ex vivo evidence for modulation of P-glycoprotein activity by progestins[J]. Biochemical pharmacology, 2004, 68 12: Pages 2409-2416. DOI: 10.1016/j.bcp.2004.08.026
Desogestrel Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Shizhou Biotechnology Co., Ltd | 025-0258556344 17301488900 | rose.shi@synzest.com | China | 271 | 58 |
| Changsha Qisheng Heyan Medical Technology Co., LTD | 18684929597 | 527907673@qq.com | China | 127 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Lianyungang Gabriel Bio-chem Technology Co., Ltd. | +86 (518) 8548-7361 | lyggabriel@163.com | China | 20 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from Desogestrel manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Desogestrel
54024-22-5
|
1KG | 99% | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-14 | Desogestrel
54024-22-5
|
1kg | 98% | 20tons | Sinoway Industrial co., ltd. | ||
 |
2026-07-27 | Desogestrel
54024-22-5
|
$38.00-103.00 | 99.95% | 10g | TargetMol Chemicals Inc. |
-
- Desogestrel
54024-22-5
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Desogestrel
54024-22-5
- 98%
- Sinoway Industrial co., ltd.
-
- Desogestrel
54024-22-5
- $38.00-103.00
- 99.95%
- TargetMol Chemicals Inc.
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