Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-chloro-3-nitro-phenol

2-chloro-3-nitro-phenol

2-chloro-3-nitro-phenol Structure
2-chloro-3-nitro-phenol structure
CAS No.
603-84-9
Chemical Name:
2-chloro-3-nitro-phenol
Synonyms
2-Chlor-3-nitrophenol;2-chloro-3-nitro-phenol;Phenol, 2-chloro-3-nitro-;2-Chloro-3-nitrophenol, 95%;3-hydroxy-2-chloronitrobenzene;2-Chlor-3-nitro-1-hydroxy-benzol
CBNumber:
CB01454716
Molecular Formula:
C6H4ClNO3
Molecular Weight:
173.55
MDL Number:
MFCD11035882
MOL File:
603-84-9.mol
MSDS File:
SDS
Last updated:2026-05-27 17:19:53
Request For Quotation

2-chloro-3-nitro-phenol Properties

Melting point 120.5 °C
Boiling point 279.6±25.0 °C(Predicted)
Density 1.554±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder
pka 7.39±0.25(Predicted)
color Gold/beige
InChI InChI=1S/C6H4ClNO3/c7-6-4(8(10)11)2-1-3-5(6)9/h1-3,9H
InChIKey QBGLHYQUZJDZOO-UHFFFAOYSA-N
SMILES C1(O)=CC=CC([N+]([O-])=O)=C1Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)Environment (GHS09)
GHS05,GHS07,GHS09
Signal word  Danger
Hazard statements  H302-H315-H317-H318-H410
Precautionary statements  P261-P264-P270-P272-P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310-P333+P313-P391-P501
HS Code  2908990000

2-chloro-3-nitro-phenol price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 269144 2-Chloro-3-nitrophenol Asreported 603-84-9 250mg $360 2026-06-03 Buy
Usbiological 269144 2-Chloro-3-nitrophenol Asreported 603-84-9 500mg $509 2026-06-03 Buy
Usbiological 269144 2-Chloro-3-nitrophenol Asreported 603-84-9 1g $724 2026-06-03 Buy
Usbiological 269144 2-Chloro-3-nitrophenol Asreported 603-84-9 2g $1055 2026-06-03 Buy
Usbiological 269144 2-Chloro-3-nitrophenol Asreported 603-84-9 5g $1646 2026-06-03 Buy
Product number Packaging Price Buy
269144 250mg $360 Buy
269144 500mg $509 Buy
269144 1g $724 Buy
269144 2g $1055 Buy
269144 5g $1646 Buy

2-chloro-3-nitro-phenol Chemical Properties, Uses, Production

Synthesis

2-Amino-3-nitrophenol

603-85-0

2-chloro-3-nitro-phenol

603-84-9

General procedure for the synthesis of 2-chloro-3-nitrophenol from 2-amino-3-nitrophenol: To a suspension of 2-amino-3-nitrophenol (10 g, 65 mmol) in concentrated hydrochloric acid (10 mL) was added drop-wise an aqueous solution (60 mL) of sodium nitrite (5.1 g, 73.3 mmol) at 0°C. The reaction mixture was stirred for 30 min at 0°C and then stirred for 18 hours. After stirring at 0°C for 30 min, cuprous chloride (12.8 g, 130 mmol) in 10% sulfuric acid (3 mL) was added and the reaction mixture was stirred for 18 hours. The non-homogeneous mixture was filtered and washed with water. The filtrate was extracted three times with 70 mL of ethyl acetate. The ethyl acetate extract was evaporated to give 7 g (62% yield) of pure 2-chloro-3-nitrophenol. 2-Chloro-3-nitrophenol (6 g, 35 mmol) was dissolved in methanol (100 mL) and ammonium chloride (9.4 g, 175.7 mmol) and zinc powder (46 g, 702.8 mmol) were added. The resulting mixture was refluxed for 1 hour. After filtration and evaporation, 2-chloro-3-aminophenol (4.5 g, 90% yield) was collected as a purple solid. To a suspension of 2-chloro-3-aminophenol (4.5 g, 31 mmol) in concentrated hydrochloric acid (10 mL) was added dropwise an aqueous solution (50 mL) of sodium nitrite (2.5 g, 35 mmol) at 0 °C. After stirring at 0°C for 30 min, a solution of iodine (10.4 g, 63 mmol) in 10% sulfuric acid (3 mL) was added dropwise. The reaction was stirred at room temperature for 2 h. The reaction was then filtered, extracted with ethyl acetate and concentrated in vacuo to afford 2-chloro-3-iodophenol as a dark purple solid (6 g, 75% yield). 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline (2.3 g, 9.2 mmol) and bis(pinacolato)diborane (4.2 g, 16.5 mmol) were combined in DMSO (2 mL). Potassium acetate (2.7 g, 27.4 mmol) was added, followed by dichlorobis(triphenylphosphine)palladium(II) (100 mg). The contents were placed in a microwave reaction vessel and irradiated at 120°C for 15 minutes. After cooling to room temperature, it was purified by chromatography to afford 2,2,4-trimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydroquinoline (2.3 g, 84% yield) as a white crystalline solid. Coupling 2,2,4-trimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydroquinoline (308 mg), 2-chloro-3-iodophenol (93 mg), dichloro-bis(triphenylphosphine)palladium(II) (100 mg), and potassium acetate (300 mg) gave 250 mg of 2-chloro-3-(2,2,4 -trimethyl-1,2-dihydroquinolin-6-yl)phenol. Using the method described in Example 7, the product (85 mg) was reacted with N-bromosuccinimide to give 56 mg of 3-(4-bromomethyl-2,2-dimethyl-1,2-dihydroquinolin-6-yl)-2-chlorophenol. The product (50 mg) was coupled with 2-phenylethanethiol (0.04 mL) to give 40 mg of the title compound as an oil.

References

[1] Patent: WO2004/18429, 2004, A2. Location in patent: Page 86-87
[2] Patent: WO2004/103996, 2004, A1. Location in patent: Page 42-43
[3] Patent: WO2006/7700, 2006, A1. Location in patent: Page/Page column 63
[4] Patent: WO2006/85, 2006, A1. Location in patent: Page/Page column 77

2-chloro-3-nitro-phenol Preparation Products And Raw materials

Raw materials

4-Chloro-3-nitrophenol 3-Nitrophenol 2-Amino-3-nitrophenol 2-Amino-5-nitrophenol Copper(I) chloride
Sodium nitrite Sulfuric acid Hydrochloric acid

1of2

Preparation Products

2-chloro-3-nitro-phenol Suppliers

Global Suppliers ( 117)
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Changzhou Huanling Chemical Co., Ltd. 89803005 18206112582 info@huanlingchem.com China 983 68
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Supplier Advantage
Capot Chemical Co., Ltd 66
Changzhou Huanling Chemical Co., Ltd. 68
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Ennopharm Co., Ltd. 65
Shanghai Topbiochem Technology Co., Ltd 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61

View Latest Price from 2-chloro-3-nitro-phenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-3-Nitro-Phenol pictures 2026-02-02 2-Chloro-3-Nitro-Phenol
603-84-9
 1G 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
2-chloro-3-nitro-phenol pictures 2019-07-06 2-chloro-3-nitro-phenol
603-84-9
 $1.00 1KG 98% 200kg Career Henan Chemical Co

2-chloro-3-nitro-phenol Spectrum

2-chloro-3-nitro-phenol(603-84-9)1HNMR2-chloro-3-nitro-phenol(603-84-9)FT-IR

603-84-9 (2-chloro-3-nitro-phenol) Related Search:

2-Chloro-6-methyl-3-nitrophenol 2,4-Dichloro-3-nitrophenol 2-chloro-3-nitro-phenol 2-Amino-4-chloro-6-nitrophenol hydrochloride 2-Chloro-4-nitrophenol
2-Amino-6-chloro-4-nitrophenol 2-Amino-4-chloro-6-nitrophenol 4-Chloro-3-nitrophenol 2,6-Dichloro-4-nitrophenol 2,4-Dichloro-6-nitrophenol
2-Chloro-5-nitrophenol 4-Chloro-2-nitrophenol Benzene, 2-chloro-1-ethoxy-3-nitro- Benzene, 2-chloro-1-methoxy-3-nitro- 2-Propanamine, 1-(2-chloro-3-nitrophenoxy)-
Benzene, 2-chloro-1-(1-methylethoxy)-3-nitro- Benzene, 2-chloro-1-nitro-3-[2-(phenylmethoxy)ethoxy]- Benzenesulfonic acid, p-chloro-, 2-chloro-3-nitrophenyl ester

1of4

2-chloro-3-nitro-phenol Phenol, 2-chloro-3-nitro- 2-Chlor-3-nitro-1-hydroxy-benzol 3-hydroxy-2-chloronitrobenzene 2-Chlor-3-nitrophenol 2-Chloro-3-nitrophenol, 95% 603-84-9 613-84-9 API intermediates Chlorine Compounds Nitro Compounds