5-Methyl-1,3-thiazole-4-carboxylic acid
- CAS No.
- 120237-76-5
- Chemical Name:
- 5-Methyl-1,3-thiazole-4-carboxylic acid
- Synonyms
- 4-Carboxy-5-methyl-1,3-thiazole;5-Methylthiazol-4-carboxylic acid;5-methyl-4-thiazolecarboxylic acid;4-Thiazolecarboxylicacid, 5-Methyl-;5-Methyl-1,3-thiazole-4-carboxylic acid
- CBNumber:
- CB01466490
- Molecular Formula:
- C5H5NO2S
- Molecular Weight:
- 143.16
- MDL Number:
- MFCD06738813
- MOL File:
- 120237-76-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 303.6±22.0 °C(Predicted) |
|---|---|
| Density | 1.418±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Solid |
| pka | 4.05±0.10(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C5H5NO2S/c1-3-4(5(7)8)6-2-9-3/h2H,1H3,(H,7,8) |
| InChIKey | OIWNDJQQIMISPC-UHFFFAOYSA-N |
| SMILES | S1C(C)=C(C(O)=O)N=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934100090 |
5-Methyl-1,3-thiazole-4-carboxylic acid price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 284617 | 5-Methyl-Thiazole-4-carboxylic acid Asreported | 120237-76-5 | 250mg | $358 | 2026-06-03 | Buy |
| Usbiological | 284617 | 5-Methyl-Thiazole-4-carboxylic acid Asreported | 120237-76-5 | 500mg | $496 | 2026-06-03 | Buy |
| Usbiological | 284617 | 5-Methyl-Thiazole-4-carboxylic acid Asreported | 120237-76-5 | 1g | $828 | 2026-06-03 | Buy |
| Usbiological | 284617 | 5-Methyl-Thiazole-4-carboxylic acid Asreported | 120237-76-5 | 2g | $1163 | 2026-06-03 | Buy |
| Usbiological | 284617 | 5-Methyl-Thiazole-4-carboxylic acid Asreported | 120237-76-5 | 5g | $1655 | 2026-06-03 | Buy |
5-Methyl-1,3-thiazole-4-carboxylic acid Chemical Properties, Uses, Production
Synthesis
68751-05-3
120237-76-5
The general procedure for the synthesis of 5-methylthiazole-4-carboxylic acid from methyl 5-methylthiazole-4-carboxylate was as follows: with reference to Example 56, to a solution of methyl 5-methyl-1,3-thiazole-4-carboxylate (1.17 g, 7.4 mmol) in methanol (15 mL) was added an aqueous solution of 8N sodium hydroxide (2.00 mL), and the reaction mixture was stirred for 18 hours at room temperature. Upon completion of the reaction, 6N hydrochloric acid (2.67 mL) was slowly added to the mixture for neutralization, followed by concentration of the mixture under reduced pressure. An appropriate amount of water was added to the concentrated residue and the precipitate precipitated was collected by filtration and washed with cold water. The resulting precipitate was suspended in a solvent mixture of ethyl acetate (9 mL) and ethanol (1 mL) and stirred at 80 °C for 3 minutes. After the mixture was cooled to room temperature, the precipitate was collected by filtration, washed with ethyl acetate and finally dried under reduced pressure to afford the target product 5-methylthiazole-4-carboxylic acid (531 mg, 50% yield) as a light yellow solid. The product was characterized by 1H-NMR (DMSO-d6, 300 MHz): δ 2.71 (3H, s), 8.87 (1H, s), 12.88 (1H, br s).
References
[1] Patent: US2009/137595, 2009, A1
[2] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 16, p. 3732 - 3736
5-Methyl-1,3-thiazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Letopharm Limited | +86-21-5821 5861 | sales@letopharm.com | China | 70 | 55 |
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