Canrenone
- CAS No.
- 976-71-6
- Chemical Name:
- Canrenone
- Synonyms
- CANRENONE-D4;sc9376;11614r.p;RP-11614;CANRENONE;phanurane;kanlitong;ALDADIENE;NSC 261713;Canrenone CRS
- CBNumber:
- CB0147626
- Molecular Formula:
- C22H28O3
- Molecular Weight:
- 340.46
- MDL Number:
- MFCD00071735
- MOL File:
- 976-71-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 158-1600C |
|---|---|
| alpha | D +24.5° (chloroform) |
| Boiling point | 416.25°C (rough estimate) |
| Density | 1.1236 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | room temp |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +17 to +24°, c = 1 in chloroform-d |
| Water Solubility | 272.4ug/L(25 ºC) |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/s3 |
| InChIKey | UJVLDDZCTMKXJK-MUWITHSMNA-N |
| SMILES | [C@@]12(CCC(=O)O1)CC[C@@]1([H])[C@]3([H])C=CC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]21C |&1:0,8,10,20,22,26,r| |
| LogP | 2.54 at 25℃ |
| CAS DataBase Reference | 976-71-6 |
| FDA UNII | 78O20X9J0U |
| ATC code | C03DA03 |
| NIST Chemistry Reference | Canrenone(976-71-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351-H411 |
| Precautionary statements | P280 |
| Hazard Codes | Xn,N |
| Risk Statements | 40-51/53 |
| Safety Statements | 36/37-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HazardClass | 9 |
| HS Code | 29329990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 2 Carc. 2 Oral |
| REACH Registrations | Active |
| Limited Quantities | 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
Canrenone price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1497 | Canrenone ≥97% (HPLC) | 976-71-6 | 50mg | $89 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2887 | Spironolactone Related Compound A pharmaceutical secondary standard, certified reference material | 976-71-6 | 150MG | $382 | 2026-04-30 | Buy |
| Sigma-Aldrich | C0410000 | Canrenone European Pharmacopoeia (EP) Reference Standard | 976-71-6 | 15 mg | $257 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1619017 | Spironolactone Related Compound A United States Pharmacopeia (USP) Reference Standard | 976-71-6 | 100mg | $1390 | 2026-04-30 | Buy |
| Cayman Chemical | 21307 | Canrenone ≥98% | 976-71-6 | 25mg | $42 | 2026-04-30 | Buy |
Canrenone Chemical Properties, Uses, Production
Chemical Properties
Pale yellow to pale Green Solid
Originator
Spiroctan,Boehringer Mannheim,Switz.,1968
Uses
Aldosterone antagonist. Diuretic
Uses
antiinflammatory, glucocorticoid
Uses
Inhibits aldosterone biosynthesis and blocks ouabain effects
Definition
ChEBI: Canrenone is a steroid lactone.
Manufacturing Process
The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl- 17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling point of the solvent under reflux overnight. The solution is then cooled and filtered through approximately 200 parts of silica gel. The gel is successively washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the washings comprising 15% ethyl acetate are thereupon purified by chromatography on a further quantity of silica gel, using benzene and ethyl acetate as developing solvents. From the 15% ethyl acetate eluate there is obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone, melting at 148° to 151°C. The product solidifies above this melting point and melts again at 165°C.
brand name
Luvion.
Therapeutic Function
Aldosterone antagonist, Diuretic
World Health Organization (WHO)
Canrenone, which has aldosterone antagonist activity, is a major metabolite of spironolactone and the major metabolite of potassium canrenoate. See WHO comments for potassium canrenoate and spironolactone.
Flammability and Explosibility
Non flammable
Biological Activity
Mineralocorticoid receptor antagonist. Active metabolite of spironolactone ((7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone ).
Biochem/physiol Actions
Canrenone is a mineralocorticoid (aldosterone) inhibitor.
Canrenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
View Latest Price from Canrenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | Canrenone
976-71-6
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-06-20 | Canrenone
976-71-6
|
$40.00 | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2025-06-20 | Canrenone
976-71-6
|
$40.00 | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
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