2-Cyano-4-fluorobenzyl bromide
- CAS No.
- 217661-27-3
- Chemical Name:
- 2-Cyano-4-fluorobenzyl bromide
- Synonyms
- 2-(broMoMethyl)-5-fluorobenzonitrile;2-cyano-4-fluorobromobenzene;2-Cyano-4-fluorobenzyl bromide;Benzonitrile, 2-(bromomethyl)-5-fluoro-;2-(bromethyl)-5-fluorobenzenemethylnitrile
- CBNumber:
- CB01479232
- Molecular Formula:
- C8H5BrFN
- Molecular Weight:
- 214.03
- MDL Number:
- MFCD09261046
- MOL File:
- 217661-27-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 2926907090 |
2-Cyano-4-fluorobenzyl bromide price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC500527 | 2-(Bromomethyl)-5-fluorobenzonitrile ≥95% | 217661-27-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC500527 | 2-(Bromomethyl)-5-fluorobenzonitrile ≥95% | 217661-27-3 | 5g | $51 | 2026-06-04 | Buy |
| Activate Scientific | AS48406 | 2-(Bromomethyl)-5-fluorobenzonitrile 97% | 217661-27-3 | 1g | $72 | 2026-06-04 | Buy |
| Activate Scientific | AS48406 | 2-(Bromomethyl)-5-fluorobenzonitrile 97% | 217661-27-3 | 5g | $141 | 2026-06-04 | Buy |
| Activate Scientific | AS48406 | 2-(Bromomethyl)-5-fluorobenzonitrile 97% | 217661-27-3 | 25g | $516 | 2026-06-04 | Buy |
2-Cyano-4-fluorobenzyl bromide Chemical Properties, Uses, Production
Synthesis
77532-79-7
217661-27-3
The general procedure for the synthesis of 2-(bromomethyl)-5-fluorobenzonitrile from 5-fluoro-2-methylbenzonitrile was as follows: first, 5-fluoro-2-methylbenzonitrile (28.51 g, 211 mmol), N-bromosuccinimide (NBS, 41.31 g, 232 mmol), and azobisisobutyronitrile (AIBN, 2.5 g, 15 mmol) were added to a carbon tetrachloride ( CCl4, 845 mL) in a mixture of nitrogen (N2) was passed for 10 min. Subsequently, the reaction mixture was heated to reflux for 8 hours. After completion of the reaction, the mixture was allowed to stand at room temperature overnight. On the following day, the reaction mixture was filtered and the filter cake was washed with carbon tetrachloride (500 mL). The filtrates were combined and the solvent was removed by evaporation to give a yellow oil. Finally, 2-(bromomethyl)-5-fluorobenzonitrile (29.74 g, 66% yield) was obtained as a light yellow oil using 5-25% ethyl acetate/hexane as eluent and purified by fast column chromatography on silica gel (SiO2). The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3) with chemical shift δ: 7.55 (1H, dd, J = 8.6,5.2 Hz), 7.37 (1H, dd, J = 7.9,2.8 Hz), 7.32-7.28 (1H, m), 4.61 (2H, s).
References
[1] Patent: US2005/267105, 2005, A1. Location in patent: Page/Page column 63
[2] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 29
[3] Patent: US2007/129379, 2007, A1. Location in patent: Page/Page column 22
[4] Patent: WO2007/64316, 2007, A1. Location in patent: Page/Page column 141
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 19, p. 3128 - 3144
2-Cyano-4-fluorobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Aspire Biological Technology Co., Ltd. | 021-61317773 | sales@aspirebio.com | China | 2880 | 58 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9792 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
