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PROTAC CDK2 Degrader-1

PROTAC CDK2 Degrader-1 structure

CAS No.: 3024971-78-3

Chemical Name:: PROTAC CDK2 Degrader-1

Synonyms: PROTAC CDK2 Degrader-1;1-(1-methyl-6-(1-((1-((4-((4-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-indazol-3-yl)dihydropyr;1-(1-methyl-6-(1-((1-((4-((4-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione

CBNumber:: CB014907809

Molecular Formula:: C38H46F6N12O4S

Molecular Weight:: 880.91

MDL Number:

MOL File:: 3024971-78-3.mol

Last updated:2025-04-17 18:22:24

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PROTAC CDK2 Degrader-1 Properties

Density	1.60±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	12.03±0.20(predicted)

PROTAC CDK2 Degrader-1 Chemical Properties, Uses, Production

Uses

PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader for cyclin-dependent kinase 2 (CDK2). PROTAC CDK2 Degrader-1 inhibits the phosphorylation of RB protein in CDK2 dependent cell line OVCAR3 with an IC50 of 100-500 nM[1].

References

[1] Yu Z, et al., Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway. WO2024102849

PROTAC CDK2 Degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC CDK2 Degrader-1 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

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PROTAC CDK2 Degrader-1 1-(1-methyl-6-(1-((1-((4-((4-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-indazol-3-yl)dihydropyr 1-(1-methyl-6-(1-((1-((4-((4-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione 3024971-78-3