5-METHYL-4-BROMOTHIOPHEN-2-YLBORONIC ACID
- CAS No.
- 154566-69-5
- Chemical Name:
- 5-METHYL-4-BROMOTHIOPHEN-2-YLBORONIC ACID
- Synonyms
- (4-Bromo-5-methylthiophen-2-yl);3-Bromo-2-methyl-5-thienylboronic acid;4-Bromo-5-methylthiophene-2-boronic acid;4-Bromo-5-methyl-2-thiopheneboronic acid;5-METHYL-4-BROMOTHIOPHEN-2-YLBORONIC ACID;(4-BroMo-5-Methylthiophen-2-yl)boronic acid;(4-bromo-5-methyl-2-thiophenyl)boronic acid;Boronic acid, B-(4-bromo-5-methyl-2-thienyl)-
- CBNumber:
- CB01519657
- Molecular Formula:
- C5H6BBrO2S
- Molecular Weight:
- 220.88
- MDL Number:
- MFCD09952079
- MOL File:
- 154566-69-5.mol
| Product description | Number | Pack Size | Price |
| 5-Methyl-4-bromothiophen-2-ylboronic acid 95% | OR360220 | 100mg | $37 |
| 5-Methyl-4-bromothiophen-2-ylboronic acid 95% | OR360220 | 250mg | $56 |
| 5-Methyl-4-bromothiophen-2-ylboronic acid 95% | OR360220 | 1g | $86 |
| 5-Methyl-4-bromothiophen-2-ylboronic acid 95% | OR360220 | 5g | $307 |
| 4-Bromo-5-methylthiophene-2-boronic acid | 092923 | 250.00mg | $49 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2934999090 |
5-METHYL-4-BROMOTHIOPHEN-2-YLBORONIC ACID price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR360220 | 5-Methyl-4-bromothiophen-2-ylboronic acid 95% | 154566-69-5 | 100mg | $37 | 2026-06-04 | Buy |
| Apolloscientific | OR360220 | 5-Methyl-4-bromothiophen-2-ylboronic acid 95% | 154566-69-5 | 250mg | $56 | 2026-06-04 | Buy |
| Apolloscientific | OR360220 | 5-Methyl-4-bromothiophen-2-ylboronic acid 95% | 154566-69-5 | 1g | $86 | 2026-06-04 | Buy |
| Apolloscientific | OR360220 | 5-Methyl-4-bromothiophen-2-ylboronic acid 95% | 154566-69-5 | 5g | $307 | 2026-06-04 | Buy |
| Matrix Scientific | 092923 | 4-Bromo-5-methylthiophene-2-boronic acid | 154566-69-5 | 250.00mg | $49 | 2026-05-18 | Buy |
5-METHYL-4-BROMOTHIOPHEN-2-YLBORONIC ACID Chemical Properties,Uses,Production
Synthesis
29421-73-6
154566-69-5
The general procedure for the synthesis of 4-bromo-5-methylthiophene-2-boronic acid from 3,5-dibromo-2-methylthiophene was as follows: 3,5-dibromo-2-methylthiophene (12.8 g, 50 mmol) was dissolved in anhydrous ether (240 mL) under argon protection and degassed. The solution was cooled to -78 °C and n-butyllithium (n-BuLi, 20.4 mL, 50 mmol, 2.5 M hexane solution) was added slowly and dropwise. The reaction mixture was stirred continuously at -78 °C for 30 min. Subsequently, tributyl borate (12.68 g, 50 mmol) was added and the reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, 1 M HCl aqueous solution (200 mL) was added for acidification, and the ether phase was separated and extracted. The ether phase was washed three times with 1 M NaOH aqueous solution (3 x 70 mL). The NaOH phases were combined, concentrated and the pH was adjusted with HCl to 1. Under this acidic condition, the target product 4-bromo-5-methylthiophene-2-boronic acid precipitated as a beige solid in 76% yield.
References
[1] European Journal of Organic Chemistry, 2011, # 18, p. 3301 - 3312
[2] Acta Crystallographica Section C: Crystal Structure Communications, 2005, vol. 61, # 10, p. o599-o601
[3] Canadian Journal of Chemistry, 2007, vol. 85, # 1, p. 12 - 20
[4] Journal of Molecular Structure, 2007, vol. 833, # 1-3, p. 23 - 29
[5] Dyes and Pigments, 2010, vol. 84, # 1, p. 25 - 35
5-METHYL-4-BROMOTHIOPHEN-2-YLBORONIC ACID Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
5-METHYL-4-BROMOTHIOPHEN-2-YLBORONIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
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| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9976 | 58 |
| Shanghai Scochem Technology Co., Ltd | +86-021-33758897 +86-13701882790 | sales@scochem.com | China | 1976 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
