methyl (4-nitro-1H-pyrazol-1-yl)acetate
- CAS No.
- 6715-84-0
- Chemical Name:
- methyl (4-nitro-1H-pyrazol-1-yl)acetate
- Synonyms
- Methyl 4-Nitro-1H-pyrazole-1-acetate;methyl 2-(4-nitropyrazol-1-yl)acetate;methyl (4-nitro-1H-pyrazol-1-yl)acetate;1H-Pyrazole-1-acetic acid, 4-nitro-, methyl ester
- CBNumber:
- CB01530175
- Molecular Formula:
- C6H7N3O4
- Molecular Weight:
- 185.14
- MDL Number:
- MFCD00297173
- MOL File:
- 6715-84-0.mol
- MSDS File:
- SDS
| Boiling point | 321.7±22.0 °C(Predicted) |
|---|---|
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | -2.71±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C6H7N3O4/c1-13-6(10)4-8-3-5(2-7-8)9(11)12/h2-3H,4H2,1H3 |
| InChIKey | GEADOFDFVOSIOA-UHFFFAOYSA-N |
| SMILES | N1(CC(OC)=O)C=C([N+]([O-])=O)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H330-H315-H318 |
| Precautionary statements | P501-P260-P271-P264-P280-P284-P302+P352-P362+P364-P332+P313-P304+P340+P310-P305+P351+P338+P310-P403+P233-P405 |
methyl (4-nitro-1H-pyrazol-1-yl)acetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 077413 | Methyl (4-nitro-1H-pyrazol-1-yl)acetate | 6715-84-0 | 500.00mg | $168 | 2026-05-18 | Buy |
| Matrix Scientific | 077413 | Methyl (4-nitro-1H-pyrazol-1-yl)acetate | 6715-84-0 | 1.00g | $210 | 2026-05-18 | Buy |
| Synthonix | M43119 | Methyl 4-Nitro-1H-pyrazole-1-acetate 98% | 6715-84-0 | 250mg | $81 | 2026-05-06 | Buy |
| Synthonix | M43119 | Methyl 4-Nitro-1H-pyrazole-1-acetate 98% | 6715-84-0 | 1g | $87 | 2026-05-06 | Buy |
| Synthonix | M43119 | Methyl 4-Nitro-1H-pyrazole-1-acetate 98% | 6715-84-0 | 5g | $90 | 2026-05-06 | Buy |
methyl (4-nitro-1H-pyrazol-1-yl)acetate Chemical Properties,Uses,Production
Uses
Methyl (4-Nitro-1H-pyrazol-1-yl)acetate is used in preparation of novel substituted glycine derivatives as Factor XIa and/or plasma kallikrein inhibitors.
Synthesis
2075-46-9
96-34-4
6715-84-0
Step 1: To a solution of 4-nitro-1H-pyrazole (100 g, 0.88 mol) in acetonitrile (ACN, 2 L) was added potassium carbonate (K2CO3, 183.2 g, 1.33 mol) and methyl chloroacetate (95.6 g, 0.88 mol). The reaction mixture was heated to 60 °C and the reaction was stirred at this temperature for 5 hours. Upon completion of the reaction, the mixture was filtered to remove insoluble solids and the solvent was subsequently removed by distillation under reduced pressure to afford methyl 2-(4-nitro-1H-pyrazol-1-yl)acetate as a white solid (150 g, 92% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.28 (s, 1H), 8.11 (s, 1H), 4.98 (s, 2H), 3.84 (s, 3H).
References
[1] Patent: WO2013/14162, 2013, A1. Location in patent: Page/Page column 99
methyl (4-nitro-1H-pyrazol-1-yl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| QINGDAO CARELONGPHARMATECH CO.,LTD | 053288191853 13061484198 | sales@carelongchem.com | China | 455 | 57 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10452 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| Changzhou Kechem Bio-Scientific Co., LTD. | 0519-68985668 13685222090 | sales@kechem.cn | China | 26012 | 58 |
