LCC-12 (formate)
- CAS No.
- Chemical Name:
- LCC-12 (formate)
- Synonyms
- LCC-12 (formate)
- CBNumber:
- CB015443025
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
LCC-12 (formate) price
LCC-12 (formate) Chemical Properties, Uses, Production
Description
LCC-12 is a copper (II) chelator and derivative of the biguanide metformin (Item No. 13118).1 It binds copper (II) as a monomer and reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+ when used at a concentration of 20 µM. LCC-12 (10 µM) decreases the levels of the cytokines IL-1β, IL-2, IL-6, IL-8, and TNF-α, as well as levels of JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4), in primary human cytokine-activated monocyte-derived macrophages (MDMs). It reduces the numbers of CD80+ and CD86+ cytokine-activated MDMs when used at a concentration of 10 µM. LCC-12 (0.3 mg/kg per day) increases survival in mouse models of sepsis induced by LPS or cecal ligation and puncture.WARNING This product is not for human or veterinary use.
References
[1] STÉPHANIE SOLIER. A druggable copper-signalling pathway that drives inflammation[J]. Nature, 2023, 617 7960: 386-394. DOI: 10.1038/s41586-023-06017-4
LCC-12 (formate) Preparation Products And Raw materials
Raw materials
Preparation Products
LCC-12 (formate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cayman Chemical Company | -- | sales@caymanchem.com | China | 6808 | 58 |
| Neobioscience Co., Ltd. | -- | info@neobioscience.com | CHINA | 6192 | 58 |
| Supplier | Advantage |
|---|---|
| Cayman Chemical Company | 58 |
| Neobioscience Co., Ltd. | 58 |
