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| | LCC-12 (formate) Basic information |
| | LCC-12 (formate) Chemical Properties |
| solubility | DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml |
| | LCC-12 (formate) Usage And Synthesis |
| Description | LCC-12 is a copper (II) chelator and derivative of the biguanide metformin (Item No. 13118).1 It binds copper (II) as a monomer and reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+ when used at a concentration of 20 µM. LCC-12 (10 µM) decreases the levels of the cytokines IL-1β, IL-2, IL-6, IL-8, and TNF-α, as well as levels of JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4), in primary human cytokine-activated monocyte-derived macrophages (MDMs). It reduces the numbers of CD80+ and CD86+ cytokine-activated MDMs when used at a concentration of 10 µM. LCC-12 (0.3 mg/kg per day) increases survival in mouse models of sepsis induced by LPS or cecal ligation and puncture.WARNING This product is not for human or veterinary use. | | References | [1] STÉPHANIE SOLIER. A druggable copper-signalling pathway that drives inflammation[J]. Nature, 2023, 617 7960: 386-394. DOI: 10.1038/s41586-023-06017-4 |
| | LCC-12 (formate) Preparation Products And Raw materials |
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