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4-amino-3-trifluoromethyl-benzoic acid methyl ester

4-amino-3-trifluoromethyl-benzoic acid methyl ester Structure
4-amino-3-trifluoromethyl-benzoic acid methyl ester structure
CAS No.
167760-75-0
Chemical Name:
4-amino-3-trifluoromethyl-benzoic acid methyl ester
Synonyms
Methyl 4-amino-3-(trifluoromethyl);Methyl 4-Amino-3-trifluoromethylbenzoate;Methyl 3-(trifluoroMethyl)-4-aMinobenzoate;4-amino-3-trifluoromethyl-benzoic acid methyl ester;Benzoic acid, 4-amino-3-(trifluoromethyl)-, methyl ester
CBNumber:
CB01563872
Molecular Formula:
C9H8F3NO2
Molecular Weight:
219.16
MDL Number:
MFCD11226326
MOL File:
167760-75-0.mol
MSDS File:
SDS
Last updated:2026-05-27 17:19:46
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4-amino-3-trifluoromethyl-benzoic acid methyl ester Properties

Boiling point 305.7±42.0 °C(Predicted)
Density 1.343
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka -0.67±0.10(Predicted)
Appearance Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335-H302
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501
HS Code  2916399090

4-amino-3-trifluoromethyl-benzoic acid methyl ester price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC201164 Methyl 4-amino-3-(trifluoromethyl)benzoate 98% 167760-75-0 100mg $21 2026-06-04 Buy
Apolloscientific PC201164 Methyl 4-amino-3-(trifluoromethyl)benzoate 98% 167760-75-0 250mg $24 2026-06-04 Buy
Apolloscientific PC201164 Methyl 4-amino-3-(trifluoromethyl)benzoate 98% 167760-75-0 1g $51 2026-06-04 Buy
Apolloscientific PC201164 Methyl 4-amino-3-(trifluoromethyl)benzoate 98% 167760-75-0 5g $169 2026-06-04 Buy
Apolloscientific PC201164 Methyl 4-amino-3-(trifluoromethyl)benzoate 98% 167760-75-0 25g $800 2026-06-04 Buy
Product number Packaging Price Buy
PC201164 100mg $21 Buy
PC201164 250mg $24 Buy
PC201164 1g $51 Buy
PC201164 5g $169 Buy
PC201164 25g $800 Buy

4-amino-3-trifluoromethyl-benzoic acid methyl ester Chemical Properties, Uses, Production

Synthesis

4-Nitro-3-trifluoromethyl-benzoic acid methyl ester

957207-00-0

4-amino-3-trifluoromethyl-benzoic acid methyl ester

167760-75-0

b) Synthesis of methyl 4-amino-3-trifluoromethyl-benzoate: 4.0 g (16.1 mmol) of methyl 4-nitro-3-trifluoromethyl-benzoate was dissolved in 50 mL of methanol and 0.4 g of 10% palladium carbon catalyst was added. The reaction mixture was stirred at room temperature and under hydrogen atmosphere (1.7 bar) for 2 hours. Upon completion of the reaction, the catalyst was diluted by adding 100 mL of ethyl acetate and filtered to remove the catalyst. The filtrate was concentrated and dried under high vacuum to afford methyl 3-trifluoromethyl-4-aminobenzoate as a white solid in 98% yield. The product did not need further purification and could be used directly in the subsequent reaction.

References

[1] Patent: US2009/163552, 2009, A1. Location in patent: Page/Page column 31
[2] Patent: EP2017263, 2009, A1. Location in patent: Page/Page column 248
[3] Patent: US2010/185419, 2010, A1
[4] Patent: WO2016/55947, 2016, A1. Location in patent: Page/Page column 61; 68

4-amino-3-trifluoromethyl-benzoic acid methyl ester Preparation Products And Raw materials

Raw materials

4-Nitro-3-trifluoromethyl-benzoic acid methyl ester Methanol 1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one Methyl 4-aminobenzoate 2-Amino-5-cyanobenzotrifluoride
4-Amino-3-(Trifluoromethyl)Benzoic Acid 3-Trifluoromethyl-4-Aminobenzoic Acid Hydrogen

1of2

Preparation Products

4-amino-3-trifluoromethyl-benzoic acid methyl ester Suppliers

Global Suppliers ( 59)
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
SynAsst Chemical. 021-60343070 China 12731 55
Xinyanhe Pharmatech Co.,Ltd 0519-85252752 15366845260 taihuaren@vip.163.com China 1032 58
Tianjin Anhao Biological Technology Co., Ltd. sales@ahpharmatech.com China 5734 55
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Changzhou Anxuan Chemical, Co., Ltd. 13912302692 sales@anxuanchem.com China 4824 58
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
Adamas Reagent, Ltd. 59
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
SuZhou ShiYa Biopharmaceuticals, Inc. 58
SynAsst Chemical. 55
Xinyanhe Pharmatech Co.,Ltd 58
Tianjin Anhao Biological Technology Co., Ltd. 55
Cool Pharm, Ltd 58
Changzhou Anxuan Chemical, Co., Ltd. 58

View Latest Price from 4-amino-3-trifluoromethyl-benzoic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-amino-3-trifluoromethyl-benzoic acid methyl ester pictures 2020-01-13 4-amino-3-trifluoromethyl-benzoic acid methyl ester
167760-75-0
 $5.50 1KG 98%min 1kg-100kg Career Henan Chemical Co

4-amino-3-trifluoromethyl-benzoic acid methyl ester Spectrum

4-amino-3-trifluoromethyl-benzoic acid methyl ester(167760-75-0)1HNMR4-amino-3-trifluoromethyl-benzoic acid methyl ester(167760-75-0)19FNMR

167760-75-0 (4-amino-3-trifluoromethyl-benzoic acid methyl ester) Related Search:

3-(Trifluoromethyl)benzoic acid 3,5-Diaminobenzoic acid 1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide 3-Cyanomethylbenzoic acid methyl ester Benzenemethanol, 4-amino-3-(trifluoromethyl)-
Methyl 2-amino-3-trifluoromethylbenzoate

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4-amino-3-trifluoromethyl-benzoic acid methyl ester Methyl 4-Amino-3-trifluoromethylbenzoate Methyl 3-(trifluoroMethyl)-4-aMinobenzoate Methyl 4-amino-3-(trifluoromethyl) Benzoic acid, 4-amino-3-(trifluoromethyl)-, methyl ester 167760-75-0