3,5-Diaminobenzoic acid
- CAS No.
- 535-87-5
- Chemical Name:
- 3,5-Diaminobenzoic acid
- Synonyms
- 3,5-DABA;3,5-DiaMinoben;3, 5-2 aMino acid;DiaMinobenzoic aci;3,5-Diaminobenzoic a;3,5-DIACETYLPYRAZINE;3,5-eranjibenjiasuan;3,5-diamino-benzoicaci;3,5-DIAMINOBENZOIC ACID;3,5-Diaminebenzoic acid
- CBNumber:
- CB4718646
- Molecular Formula:
- C7H8N2O2
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00007807
- MOL File:
- 535-87-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,5-Diaminobenzoic acid 98% | D12805 | 100g | $68 |
| 3,5-Diaminobenzoic acid 98% | D12805 | 1kg | $667 |
| 3,5-Diaminobenzoic Acid >98.0%(HPLC)(T) | D0294 | 25g | $65 |
| 3,5-Diaminobenzoic Acid >98.0%(HPLC)(T) | D0294 | 100g | $170 |
| 3,5-Diaminobenzoic acid Asreported | 273431 | 250g | $252 |
| More product size | |||
| Melting point | 235-238 °C (dec.) (lit.) |
|---|---|
| Boiling point | 274.61°C (rough estimate) |
| Density | 1.2804 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5200 (estimate) |
| Flash point | 235-240°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Powder |
| pka | pK1:5.30 (25°C) |
| color | White to gray |
| Water Solubility | Very soluble in water. |
| Decomposition | 235-240 ºC |
| Merck | 14,2978 |
| BRN | 2086484 |
| InChI | 1S/C7H8N2O2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3H,8-9H2,(H,10,11) |
| InChIKey | UENRXLSRMCSUSN-UHFFFAOYSA-N |
| SMILES | Nc1cc(N)cc(c1)C(O)=O |
| LogP | -0.51 |
| CAS DataBase Reference | 535-87-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1609U1093N |
| EPA Substance Registry System | Benzoic acid, 3,5-diamino- (535-87-5) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H341-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P501a-P201-P202-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DG6186000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29224995 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
3,5-Diaminobenzoic acid price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D12805 | 3,5-Diaminobenzoic acid 98% | 535-87-5 | 100g | $68 | 2026-04-30 | Buy |
| Sigma-Aldrich | D12805 | 3,5-Diaminobenzoic acid 98% | 535-87-5 | 1kg | $667 | 2026-04-30 | Buy |
| TCI Chemical | D0294 | 3,5-Diaminobenzoic Acid >98.0%(HPLC)(T) | 535-87-5 | 25g | $65 | 2026-04-30 | Buy |
| TCI Chemical | D0294 | 3,5-Diaminobenzoic Acid >98.0%(HPLC)(T) | 535-87-5 | 100g | $170 | 2026-04-30 | Buy |
| Usbiological | 273431 | 3,5-Diaminobenzoic acid Asreported | 535-87-5 | 250g | $252 | 2026-06-03 | Buy |
3,5-Diaminobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
White to grey powder
Uses
3,5-diaminobenzoic acid be used as organic intermediates.
Uses
3,5-Diaminobenzoic acid is an analog of diatriazoate, which has been shown to have antigenicity properties towards the monoclonal antibodies. It is used as pharmaceutical intermediate.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
99-34-3
535-87-5
General procedure for the synthesis of 3,5-diaminobenzoic acid from 3,5-dinitrobenzoic acid: 3,5-dinitrobenzoic acid (51 g, 0.24 mol) and 300 mL of water were added to a 1 L stainless steel high-pressure reactor and stirred thoroughly until homogeneous. Subsequently, the pH of the reaction system was adjusted to 7-8 using an aqueous sodium hydroxide solution with a mass percent concentration of 20%. 0.25 g of Ni-Yb-Al triple-acting catalyst was added followed by three nitrogen substitutions to remove air. The hydrogen pressure was controlled at 0.2 MPa and the reaction temperature was maintained at 25-30 °C until the reaction pressure decreased significantly, indicating the completion of the reaction. Upon completion of the reaction, the catalyst was recovered by filtration. The filtrate was adjusted to pH 3 with concentrated hydrochloric acid to precipitate the target product 3,5-diaminobenzoic acid. The solid product was collected by filtration, washed with water and finally dried under vacuum to give 36.5 g of 3,5-diaminobenzoic acid in 98.8% yield and 98.9% HPLC purity. The retention time of the product was consistent with the standard control.
Purification Methods
Crystallise the acid from water. The dihydrochloride has m 226-228o(dec). [Beilstein 14 H 453, 14 III 1179, 14 IV 1304.]
References
[1] Patent: CN105949076, 2016, A. Location in patent: Paragraph 0025; 0026; 0031; 0036; 0040; 0045; 0053
[2] Journal of the Iranian Chemical Society, 2014, vol. 11, # 6, p. 1587 - 1592
[3] Synthetic Communications, 2000, vol. 30, # 20, p. 3639 - 3644
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 9, p. 709 - 711
[5] Synthetic Communications, 2003, vol. 33, # 2, p. 281 - 289
3,5-Diaminobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Yuanda Chemical Co., Ltd | 28-85356300 +8618980937689 | sales@ydachem.com | CHINA | 94 | 58 |
| Shanghai Daeyeon Chemicals Co., Ltd | 021-64478606 +8615900664856 | daeyeon001@vip.163.com | China | 2062 | 58 |
| Asia Chem I and E (Jiangsu) Co Ltd | +8615105181882 | mera.z@nitrobenzenechemical.com | China | 140 | 58 |
| Suzhou Laing Biotechnology Co.,Ltd | +86-13004516015 +86-18149392822 | christina@laingbiotec.com | China | 777 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5225 | 58 |
| CHINATECH(TIANJIN) CHEMICAL CO.,LTD. | +86-86-18222270857 +8618222270857 | sales5@chinatechem.com | China | 99 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
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View Lastest Price from 3,5-Diaminobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-24 | 3,5-Diaminobenzoic acid
535-87-5
|
$75.00-100.00 | 1g | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-06-24 | 3,5-Diaminobenzoic acid
535-87-5
|
$36.28 | 25Kg/Drum | 99.50%HPLC | 10tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2026-06-24 | 3,5-Diaminobenzoic acid
535-87-5
|
1KG | 98%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- 3,5-Diaminobenzoic acid
535-87-5
- $75.00-100.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 3,5-Diaminobenzoic acid
535-87-5
- $36.28
- 99.50%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 3,5-Diaminobenzoic acid
535-87-5
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
