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FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10)

FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) Structure
FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) structure
CAS No.
163973-98-6
Chemical Name:
FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10)
Synonyms
H-THR-GLU-ASN-LEU-GLU-PRO-ASN-GLY-GLU-GLY-NH2;FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10);Glycinamide, L-threonyl-L-α-glutamyl-L-asparaginyl-L-leucyl-L-α-glutamyl-L-prolyl-L-asparaginylglycyl-L-α-glutamyl- (9CI);(4S)-4-[[2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-5-[(2-amino-2-oxoethyl)amino]-5-oxopentanoic acid
CBNumber:
CB0169020
Molecular Formula:
C42H67N13O19
Molecular Weight:
1058.06
MDL Number:
MFCD00677050
MOL File:
163973-98-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:21
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FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) Properties

Boiling point 1757.1±65.0 °C(Predicted)
Density 1.420±0.06 g/cm3(Predicted)
storage temp. -15°C
pka 4.41±0.10(Predicted)
form Solid
color White to off-white
Sequence Thr-Glu-Asn-Leu-Glu-Pro-Asn-Gly-Glu-Gly-NH2

FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0646601 Fsh receptor-binding inhibitor fragment(bi-10) 99.19% 163973-98-6 5mg $141 2026-06-04 Buy
ChemScene CS-0646601 Fsh receptor-binding inhibitor fragment(bi-10) 99.19% 163973-98-6 10mg $227 2026-06-04 Buy
aablocks AA00AB8D FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) >98% 163973-98-6 5mg $180 2026-05-28 Buy
aablocks AA00AB8D FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) >98% 163973-98-6 10mg $269 2026-05-28 Buy
Arctom HY-P4190 Fsh receptor-binding inhibitor fragment(bi-10) 99.19% 163973-98-6 5mg $124 2026-05-26 Buy
Product number Packaging Price Buy
CS-0646601 5mg $141 Buy
CS-0646601 10mg $227 Buy
AA00AB8D 5mg $180 Buy
AA00AB8D 10mg $269 Buy
HY-P4190 5mg $124 Buy

FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) Chemical Properties, Uses, Production

Uses

FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries[1].

in vivo

FSH receptor-binding inhibitor fragment(bi-10) (10, 20, 30, 40 mg/kg; Intramuscularly injection; once a day for five consecutive days) with high dose (30 mg/kg to 40 mg/kg) can suppress ovarian and follicular development, and attenuate expression levels of ERβ and FSHR mRNAs and proteins in the ovaries, additionally inhibit E2 production[1].

Animal Model:Prepuberty Kunming female mice of 21-days old and body weight of 22.3±1.52g[1]
Dosage:10, 20, 30, 40 mg/kg
Administration:Intramuscularly injection; once a day for five consecutive days
Result:Could attenuate FSH promoting effect on the follicular development, resulting in the poor maturation of ovarian follicles.
High dose (40mg/kg) treatment blocked the follicle development of mice.
High dose of FRBI (40mg/kg) treatment blocked the follicle development of mice.

References

[1] Gong Zhuandi, et al. FSH receptor binding inhibitor restrains follicular development and possibly attenuates carcinogenesis of ovarian cancer through down-regulating expression levels of FSHR and ERβ in normal ovarian tissues. Gene. 2018 Aug 20;668:174-181. DOI:10.1016/j.gene.2018.05.068

FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) Preparation Products And Raw materials

Raw materials

Preparation Products

FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) Suppliers

Global Suppliers ( 14)
Supplier Tel Email Country ProdList Advantage
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Nanjing Peptide Biotech Ltd. 025-58361106-805 15951641583 zhao.xu@njpeptide.com China 9976 55
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 15967184799 Eric@peptidego.com China 7872 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19087 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703 3007955328@qq.com China 7446 58
Shanghai HongTide Biotechnology Co.,Ltd. 15318089928 alex@hanhonggroup.com China 4604 58
Shanghai Easy CDMO Co.,Ltd Info@easycdmo.com 13564957716 Info@easycdmo.com China 9999 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29982 58
Supplier Advantage
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Nanjing Peptide Biotech Ltd. 55
Hangzhou Peptidego Biotech Co.,Ltd. 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 58
Shanghai HongTide Biotechnology Co.,Ltd. 58
Shanghai Easy CDMO Co.,Ltd 58
https://hanhongsci.com/ 58

163973-98-6 (FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10)) Related Search:

Proline, 4-amino-3-hydroxy-5-oxo- (9CI) FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) (2S,4S)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride Gly-Pro-hydroxy-Pro acetate salt L-Proline, L-threonylglycyl-L-serylglycyl-L-threonyl-
L-Valine, L-lysyl-L-threonyl-L-lysyl-L-α-glutamylglycyl-

1of2

H-THR-GLU-ASN-LEU-GLU-PRO-ASN-GLY-GLU-GLY-NH2 FSH RECEPTOR-BINDING INHIBITOR FRAGMENT (BI-10) (4S)-4-[[2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-5-[(2-amino-2-oxoethyl)amino]-5-oxopentanoic acid Glycinamide, L-threonyl-L-α-glutamyl-L-asparaginyl-L-leucyl-L-α-glutamyl-L-prolyl-L-asparaginylglycyl-L-α-glutamyl- (9CI) 163973-98-6 C42H67N13O19