posizolid
- CAS No.
- 252260-02-9
- Chemical Name:
- posizolid
- Synonyms
- AZD2563;AZD5847;posizoli;AZD 5847;AZD 2563;AZD-2563;AZD-5847;posizolid;Posizolid-13C2D4;AZD-2563, Posizolid
- CBNumber:
- CB01856064
- Molecular Formula:
- C21H21F2N3O7
- Molecular Weight:
- 465.407
- MDL Number:
- MFCD27987906
- MOL File:
- 252260-02-9.mol
- MSDS File:
- SDS
| Boiling point | 724.5±60.0 °C(Predicted) |
|---|---|
| Density | 1.491 |
| pka | 12.79±0.20(Predicted) |
| FDA UNII | 82V2M8K24R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
posizolid Chemical Properties,Uses,Production
Uses
Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity[1].
in vivo
AZD5847 DSP (AZD2563 is prodrug) could not be detected in plasma 5 min after oral administration, suggesting rapid conversion of the prodrug to the parent molecule.
In PK analysis, AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h[3].
| Animal Model: | Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3]. |
| Dosage: | 3, 10, 30, 100, 300, 600, and 900 mg/kg |
| Administration: | oral; collect blood samples at 5 min, 10 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, and 24 h |
| Result: | AZD5847 DSP can’t be detected in plasma 5 min. |
| Animal Model: | Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3]. |
| Dosage: | 250 mg/kg |
| Administration: | oral; collect blood and BAL fluid samples at 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 16 h, 24 h, and 48 h |
| Result: | AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h. |
IC 50
Oxazolidinone
References
[1] Kumar D, et al. The anti-tuberculosis agents under development and the challenges ahead. Future Med Chem. 2015;7(15):1981-2003. DOI:10.4155/fmc.15.128
[2] Baum SE, et al. Comparative activities of the oxazolidinone AZD2563 and linezolid against selected recent North American isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2002;46(9):3094-3095. DOI:10.1128/AAC.46.9.3094-3095.2002
[3] Balasubramanian V, et al. Pharmacokinetic and pharmacodynamic evaluation of AZD5847 in a mouse model of tuberculosis. Antimicrob Agents Chemother. 2014;58(7):4185-4190. DOI:10.1128/AAC.00137-14
posizolid Preparation Products And Raw materials
Raw materials
Preparation Products
posizolid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22866 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| SembCorp Shenzhenshibai a Biotechnology Co., Ltd | 13412890622 | China | 23 | 55 | |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20033 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |
