(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate
- CAS No.
- 173604-87-0
- Chemical Name:
- (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate
- Synonyms
- (5-Methyl-2-oxo-1,3-dioxol-4-yl)methylp-nitrophenyl carbonate;(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate;(5-methyl-2-oxo-1,3-dioxopentene-4-yl) methyl 4-nitrophenyl carbonate;Carbonic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl -ester;carbonic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester 4-nitro-phenyl ester
- CBNumber:
- CB01876499
- Molecular Formula:
- C12H9NO8
- Molecular Weight:
- 295.2
- MDL Number:
- MFCD04035556
- MOL File:
- 173604-87-0.mol
- MSDS File:
- SDS
| Boiling point | 434.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.491 |
| InChI | InChI=1S/C12H9NO8/c1-7-10(21-12(15)19-7)6-18-11(14)20-9-4-2-8(3-5-9)13(16)17/h2-5H,6H2,1H3 |
| InChIKey | MZGIKNSLLFWGKL-UHFFFAOYSA-N |
| SMILES | C(OC1=CC=C([N+]([O-])=O)C=C1)(=O)OCC1=C(C)OC(=O)O1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS03,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H272-H411 |
| Precautionary statements | P210-P220-P221P280-P370+P378-P501 |
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM148902 | (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate | 173604-87-0 | 50mg | $150 | 2026-06-04 | Buy |
| Biosynth | FM148902 | (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate | 173604-87-0 | 25mg | $150 | 2026-06-04 | Buy |
| Biosynth | FM148902 | (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate | 173604-87-0 | 100mg | $169 | 2026-06-04 | Buy |
| Biosynth | FM148902 | (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate | 173604-87-0 | 250mg | $337.5 | 2026-06-04 | Buy |
| Matrix Scientific | 297320 | (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (4-nitrophenyl) carbonate | 173604-87-0 | 250.00mg | $54 | 2026-05-19 | Buy |
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Chemical Properties, Uses, Production
Uses
(5-Methyl-2-oxo-1,3-dioxol-4-YL)methyl 4-nitrophenyl carbonate is a pharmaceutical intermediate compound for the preparation of Ceftobiprole medocaril, a broad-spectrum, 5th generation cephalosporin with activity against gram-positive bacteria (e.g. methicillin-resistant).
Synthesis
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate is prepared by the reaction of 4-Nitrophenyl chloroformate and Bis(4-nitrophenyl) carbonate. The specific synthesis steps are as follows:
4-Hydroxymethyl-5-methyl-1,3-doxolene-2-one (5.59 g) and pyridine (3.74 g) were dissolved in 50 mL of chloroform and cooled in an ice bath. 4-Nitrophenylchloroformate (9.46 g) dissolvedin chloroform (50 mL) was added dropwise to the above solution.
The mixture was stirred for 16 hours at room temperature.
The reaction mixture was cooled in ice and washed with ice cold 1percent sodium hydroxide, 1N hydrochloric acid, water and brine and dried over sodium sulfate.
Evaporation of the organic layer resulted in 11.2 g of crude product, which was crystallized from chloroform/hexane.
The crystals formed were filtered and washed with ice cold hexane/chloroform (1:1), to obtain the pure 4-nitrophenyl carbonate (9.11 g, 81percent); mp 116°-117°; 1 H NMR (CDCl3) δ2.23 (s, 3H), 5.05 (s,2H), 7.41 (d, 2H), 8.3 (s, 2H); 13 C NMR (CDCl3), δ9.43, 58.07, 121.69, 121.35, 132.15, 141.42, 145.57, 151.66, 152.19, 155.05; IR (KBr) 1779, 1811, 1525, 1247, 1221, 1207 cm-1.
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Guoding Pharmaceutical Technology Co., Ltd. | 053167801621 15665775653 | sales@guodingpharma.com | China | 480 | 58 |
| Shanghai Weishukur Medical Technology Co., LTD | 15250615384 | 316228842@qq.com | China | 321 | 58 |
| Hainan Keqing Biotechnology Co., Ltd. | 17384945703;17384945703 | 425796769@qq.com | China | 36 | 58 |
| Tianjin Olefin Pharmaceutical Co., Ltd. | 18202662021 18522876413 | 2781212171@qq.com | China | 313 | 56 |
| Tianjin Propharm Co., Ltd. | 185-11025967 18511025967 | wubin@propharm.cn | China | 60 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
View Latest Price from (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate
173604-87-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate
173604-87-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
173604-87-0 ((5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate) Related Search:
1of4
