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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE structure

CAS No.: 136132-67-7

Chemical Name:: N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

Synonyms: CTSB;CPSB;ACC4;ACC5;ACC-4;ACC-5;z-rr-amc;APP secretase;Z-RR-AMC, 2HCL;Z-ARG-ARG-MCA.HCL

CBNumber:: CB0188887

Molecular Formula:: C30H40ClN9O6

Molecular Weight:: 658.15

MDL Number:: MFCD00133576

MOL File:: 136132-67-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:21:21

Product description	Number	Pack Size	Price
Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	C5429	5mg	$98.4
Cathepsin B Active human recombinant, expressed in FreeStyle? 293-F cells, ≥90% (SDS-PAGE)	SRP0289	10μG	$758
Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	C5429	25mg	$355
Cathepsin B Substrate III, Fluorogenic Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.	219392	25MG	$189
CTSB Purifiedbyimmunoaffinitychromatography.	521930	100ul	$736

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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Properties

storage temp.	-20°C
solubility	DMSO: 5mg/mL water: soluble
form	aqueous solution
color	White to off-white
biological source	human
Water Solubility	water: soluble
Specific Activity	≥2228pmol/min-μg
Sequence	Z-Arg-Arg-AMC
InChIKey	HLSNWWKWVKPXKI-UHFFFAOYSA-N
SMILES	Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12
UNSPSC Code	51111800
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H315-H319-H360D
Precautionary statements	P201-P302+P352-P305+P351+P338-P308+P313
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
Storage Class	11 - Combustible Solids

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C5429	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	136132-67-7	5mg	$98.4	2026-04-30	Buy
Sigma-Aldrich	SRP0289	Cathepsin B Active human recombinant, expressed in FreeStyle? 293-F cells, ≥90% (SDS-PAGE)	136132-67-7	10μG	$758	2026-04-30	Buy
Sigma-Aldrich	C5429	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	136132-67-7	25mg	$355	2026-04-30	Buy
Sigma-Aldrich	219392	Cathepsin B Substrate III, Fluorogenic Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.		25MG	$189	2026-04-30	Buy
Usbiological	521930	CTSB Purifiedbyimmunoaffinitychromatography.		100ul	$736	2026-06-03	Buy

Product number	Packaging	Price	Buy
C5429	5mg	$98.4	Buy
SRP0289	10μG	$758	Buy
C5429	25mg	$355	Buy
219392	25MG	$189	Buy
521930	100ul	$736	Buy

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

as a cathepsin B substrate in zymography analysis of protease in feces extract.
in cathepsin B activity assay.
as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

General Description

Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.

Biochem/physiol Actions

Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Suppliers

Global( 111)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9996	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	3016	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
DONBOO AMINO ACID COMPANY	+8618051385538	donboo@donboo.com	China	9363	58
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9815	79
Bide Pharmatech Ltd.	400-400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai Macklin Biochemical Co.,Ltd.	15221275939; 15221275939	shenlinxing@macklin.cn	China	15781	55

Supplier	Advantage
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
Zhengzhou Anbu Chem Co.,Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
DONBOO AMINO ACID COMPANY	58
Sinopharm Chemical Reagent Co,Ltd.	79
Bide Pharmatech Ltd.	60
Shanghai Macklin Biochemical Co.,Ltd.	55

View Lastest Price from N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride 136132-67-7	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2020-01-09	N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 136132-67-7	$1.00	1g	≥98%		Career Henan Chemical Co

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
136132-67-7
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
136132-67-7
$1.00
≥98%
Career Henan Chemical Co

136132-67-7(N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE)Related Search:

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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL Z-ARG-ARG-AMC 2HCL Z-ARG-ARG-AMC HYDROCHLORIDE SALT Z-ARG-ARG-MCA HYDROCHLORIDE Z-ARG-ARG-MCA(HYDROCHLORIDE FORM) Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL Z-RR-AMC, 2HCL z-arg-arg-7-amido-4-methylcoumarin hydrochloride z-rr-amc Z-ARG-ARG-MCA.HCL ANTI-CATB (CENTER) antibody produced in rabbit APP secretase CPSB Cathepsin B Active human Z-Arg-Arg-7-amido-4-methylcoumarin BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE CATHEPSIN B SUBSTRATE III, FLUOROGENIC CATHEPSIN B SUBSTRATE IV, FLUOROGENIC na-cbz-arg-arg 7-amido-4-methylcoumarin hydrochlo NA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORI N-CBZ-ILE-GLU-THR-ASP-7-AMINO-4- TRIFLUO ROMETHYLCOU Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,Z-RR-AMC Recombinant Human Cathepsin B/CTSB Protein, His Tag Recombinant Mouse Cathepsin B/Ctsb Protein, His Tag N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE USP/EP/BP Z-Arg-Arg-AMC/Z-RR-AMC CBZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride Z-Arg-Arg-AMC hydrochloride Mouse Anti-Caspase 8 antibody ACC4 ACC-4 ACC5 ACC-5 Z-Arg-Arg-AMC · HCl CTSB 136132-67-7 C30H39N9O6 C30H41Cl2N9O6 C30H39N9O6HCl C30H40ClN9O6 Cathepsins and Granzymes Cathepsin B Caspases Caspase 8 Cell Signaling and Neuroscience Cell Biology Apoptosis and Cell Cycle BioChemical Substrates Substrates