ChemicalBook >> CAS DataBase List >>2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]
![2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Structure](CAS/20180711/GIF/445222-91-3.gif)
- CAS No.
- 445222-91-3
- Chemical Name:
- 2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]
- Synonyms
- EMBL;MuRF1-IN-1;MuRF1-IN-1, 10 mM in DMSO;MuRF1IN1,inhibit,Inhibitor,MuRF1 IN 1,MuRF-1-IN-1;2-Amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile;2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene];Spiro[4H-1-benzopyran-4,3'-[3H]indole]-3-carbonitrile, 2-amino-1',2',5,6,7,8-hexahydro-1'-methyl-2',5-dioxo-
- CBNumber:
- CB01966147
- Molecular Formula:
- C18H15N3O3
- Molecular Weight:
- 321.33
- MDL Number:
- MOL File:
- 445222-91-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-27 17:00:41
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Properties
| Melting point | 247-248 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 716.6±60.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 125 mg/mL (389.01 mM; Need ultrasonic) |
| pka | 2.42±0.20(Predicted) |
| form | Solid |
| color | Off-white to gray |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VSA22291 | Murf1-in-1 | 445222-91-3 | 25mg | $1119.5 | 2026-06-05 | Buy |
| Biosynth | VSA22291 | Murf1-in-1 | 445222-91-3 | 50mg | $1557.5 | 2026-06-05 | Buy |
| Biosynth | VSA22291 | Murf1-in-1 | 445222-91-3 | 100mg | $2492 | 2026-06-05 | Buy |
| ChemScene | CS-0106444 | MuRF1-IN-1 98.16% | 445222-91-3 | 5mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0106444 | MuRF1-IN-1 98.16% | 445222-91-3 | 10mg | $347 | 2026-06-04 | Buy |
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Chemical Properties, Uses, Production
Uses
MuRF1-IN-1 is a muscle ring finger 1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia[1].
Biological Activity
MuRF1-IN-1 is a muscle ring finger 1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia[1].
References
[1]. Bowen TS, Adams V, Werner S, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Preparation Products And Raw materials
Raw materials
Preparation Products
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Suppliers
Global Suppliers ( 25)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9787 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shandong Jirun Biomedical Technology Co., Ltd. | 0539-0539-8613587 17661611089 | 2639273505@qq.com | China | 237 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2232176231@qq.com | China | 9996 | 58 |
View Latest Price from 2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-21 | MuRF1-IN-1
445222-91-3
|
$32.00-111.00 | 98.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | MuRF1-IN-1
445222-91-3
|
$32.00-111.00 | 98.88% | 10g | TargetMol Chemicals Inc. |
-
- MuRF1-IN-1
445222-91-3
- $32.00-111.00
- 98.88%
- TargetMol Chemicals Inc.
-
- MuRF1-IN-1
445222-91-3
- $32.00-111.00
- 98.88%
- TargetMol Chemicals Inc.
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Spectrum
445222-91-3 (2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]) Related Search:
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]
MuRF1-IN-1
EMBL
2-Amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile
MuRF1IN1,inhibit,Inhibitor,MuRF1 IN 1,MuRF-1-IN-1
Spiro[4H-1-benzopyran-4,3'-[3H]indole]-3-carbonitrile, 2-amino-1',2',5,6,7,8-hexahydro-1'-methyl-2',5-dioxo-
MuRF1-IN-1, 10 mM in DMSO
445222-91-3
