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ChemicalBook >> CAS DataBase List >>14,15-Leukotriene C4

14,15-Leukotriene C4

14,15-Leukotriene C4 Structure
14,15-Leukotriene C4 structure
CAS No.
75290-60-7
Chemical Name:
14,15-Leukotriene C4
Synonyms
EXC4;EOXIN C4;14,15-LTC4;14,15-Leukotriene C4;OBQVBASHEWLKCQ-PKBWNXTMSA-N;Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
CBNumber:
CB0196624
Molecular Formula:
C30H47N3O9S
Molecular Weight:
625.78
MDL Number:
MFCD00211501
MOL File:
75290-60-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:47:37
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14,15-Leukotriene C4 Properties

Boiling point 976.847±65.00 °C(Press: 760.00 Torr)(predicted)
Density 1.226±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at -20°C
solubility DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 100 μg/ml
form Liquid.
pka 2.214±0.10(predicted)

14,15-Leukotriene C4 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10011360 14,15-Leukotriene C4 ≥95% 75290-60-7 25μg $140 2026-04-30 Buy
Cayman Chemical 10011360 14,15-Leukotriene C4 ≥95% 75290-60-7 50μg $260 2026-04-30 Buy
Cayman Chemical 10011360 14,15-Leukotriene C4 ≥95% 75290-60-7 100μg $492 2026-04-30 Buy
ChemScene CS-0107827 14,15-Leukotriene C4 75290-60-7 25μg $302 2026-06-04 Buy
ChemScene CS-0107827 14,15-Leukotriene C4 75290-60-7 50μg $562 2026-06-04 Buy
Product number Packaging Price Buy
10011360 25μg $140 Buy
10011360 50μg $260 Buy
10011360 100μg $492 Buy
CS-0107827 25μg $302 Buy
CS-0107827 50μg $562 Buy

14,15-Leukotriene C4 Chemical Properties, Uses, Production

Description

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.

Uses

14,15-Leukotriene C4 is an acute inflammatory mediator.

References

[1] M LUO  T G B  S Lee. Leukotriene synthesis by epithelial cells.[J]. Histology and histopathology, 2003, 18 2: 587-595. DOI: 10.14670/hh-18.587
[2] C. YOKOYAMA. Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids.[J]. The Journal of Biological Chemistry, 1986, 61 1: 16714-16721. DOI: 10.1016/s0021-9258(18)66623-2
[3] R. BRYANT. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4.[J]. The Journal of Biological Chemistry, 1985, 43 1: 3548-3555. DOI: 10.1016/s0021-9258(19)83657-8
[4] STINA FELTENMARK. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 680-685. DOI: 10.1073/pnas.0710127105
[5] SAILESH S. Sheep Uterus Dual Lipoxygenase in the Synthesis of 14,15-Leukotrienes[J]. Archives of biochemistry and biophysics, 1994, 315 2: Pages 362-368. DOI: 10.1006/abbi.1994.1512
[6] J M DRAZEN. Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1981, 78 5: 3195-3198. DOI: 10.1073/pnas.78.5.3195
[7] A SALA. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea-pig ileum.[J]. Eicosanoids, 1990, 3 2: 105-110.

14,15-Leukotriene C4 Preparation Products And Raw materials

Raw materials

Preparation Products

14,15-Leukotriene C4 Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7982 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Shaanxi Didu Pharmaceutical Co., Ltd. 029-81124775 17791530730 1079@dideu.com China 10000 58
Aladdin Scientific tp@aladdinsci.com United States 50068 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Shaanxi Didu Pharmaceutical Co., Ltd. 58
Aladdin Scientific 58

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14,15-LTC4 EOXIN C4 EXC4 OBQVBASHEWLKCQ-PKBWNXTMSA-N Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl- 14,15-Leukotriene C4 75290-60-7