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| | 14,15-Leukotriene C4 Basic information |
| Product Name: | 14,15-Leukotriene C4 | | Synonyms: | 14,15-LTC4;EOXIN C4;EXC4;OBQVBASHEWLKCQ-PKBWNXTMSA-N;Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-;14,15-Leukotriene C4 | | CAS: | 75290-60-7 | | MF: | C30H47N3O9S | | MW: | 625.78 | | EINECS: | | | Product Categories: | | | Mol File: | 75290-60-7.mol |  |
| | 14,15-Leukotriene C4 Chemical Properties |
| Boiling point | 976.847±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.226±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 100 μg/ml | | form | Liquid. | | pka | 2.214±0.10(predicted) |
| | 14,15-Leukotriene C4 Usage And Synthesis |
| Description | Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation. | | Uses | 14,15-Leukotriene C4 is an acute inflammatory mediator. | | References | [1] M LUO T G B S Lee. Leukotriene synthesis by epithelial cells.[J]. Histology and histopathology, 2003, 18 2: 587-595. DOI: 10.14670/hh-18.587
[2] C. YOKOYAMA. Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids.[J]. The Journal of Biological Chemistry, 1986, 61 1: 16714-16721. DOI: 10.1016/s0021-9258(18)66623-2
[3] R. BRYANT. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4.[J]. The Journal of Biological Chemistry, 1985, 43 1: 3548-3555. DOI: 10.1016/s0021-9258(19)83657-8
[4] STINA FELTENMARK. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 680-685. DOI: 10.1073/pnas.0710127105
[5] SAILESH S. Sheep Uterus Dual Lipoxygenase in the Synthesis of 14,15-Leukotrienes[J]. Archives of biochemistry and biophysics, 1994, 315 2: Pages 362-368. DOI: 10.1006/abbi.1994.1512
[6] J M DRAZEN. Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1981, 78 5: 3195-3198. DOI: 10.1073/pnas.78.5.3195
[7] A SALA. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea-pig ileum.[J]. Eicosanoids, 1990, 3 2: 105-110.
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| | 14,15-Leukotriene C4 Preparation Products And Raw materials |
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