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ChemicalBook >> CAS DataBase List >>L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Structure
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid structure
CAS No.
74163-81-8
Chemical Name:
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Synonyms
Tic-OH;(S)-TIC;L-TIC HCL;L-1,2,3,4-Tetrahydro;Icatibant Impurity 14;Quinapril Bicyclic Acid;Quinapril EP Impurity A;(S)-1,2,3,4-Tetrahydro-3-isoquinoL;Quinapril Hydrochloride Impurity A;(3S)-1,2,3,4-Tetrahydroisoquinoline
CBNumber:
CB0197924
Molecular Formula:
C10H11NO2
Molecular Weight:
177.2
MDL Number:
MFCD00800357
MOL File:
74163-81-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:21:34
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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Properties

Melting point >300 °C(lit.)
Boiling point 309.12°C (rough estimate)
alpha -157.4 º (24 ºC)
Density 1.1607 (rough estimate)
refractive index -166 ° (C=1, 1mol/L NaOH)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility soluble in Hot Water, Basic Water
form powder to crystal
pka 2.21±0.20(Predicted)
color White to Almost white
optical activity [α]20/D 168°, c = 1.8 in 1.4 M NaOH
BRN 4842199
Major Application peptide synthesis
InChI 1S/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)/t9-/m0/s1
InChIKey BWKMGYQJPOAASG-VIFPVBQESA-N
SMILES OC(=O)[C@@H]1Cc2ccccc2CN1
CAS DataBase Reference 74163-81-8(CAS DataBase Reference)
FDA UNII 737G46U1NP
UNSPSC Code 12352106
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HS Code  29334900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 421626 (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid 97% 74163-81-8 5g $27.5 2026-04-30 Buy
TCI Chemical T1515 (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid >98.0%(T) 74163-81-8 5g $55 2026-04-30 Buy
TCI Chemical T1515 (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid >98.0%(T) 74163-81-8 25g $159 2026-04-30 Buy
TRC TRC-T293755-5G (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid 74163-81-8 5g $65 2026-06-03 Buy
TRC TRC-T293755-25G (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid 74163-81-8 25g $246 2026-06-03 Buy
Product number Packaging Price Buy
421626 5g $27.5 Buy
T1515 5g $55 Buy
T1515 25g $159 Buy
TRC-T293755-5G 5g $65 Buy
TRC-T293755-25G 25g $246 Buy

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Chemical Properties, Uses, Production

Description

(S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a quinoline derivative, which is used as an intermediate in the synthesis of quinapril. Quinapril, a product developed by Pfizer, was approved by the US FDA in 1991 for the treatment of hypertension, congestive heart failure and angioedema.

Chemical Properties

white to light yellow crystal powde

Uses

(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Quinapril EP Impurity A) is a Quinapril intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 2-Benzoyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (3S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ethyl ester 1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester
Benzyl (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride

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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Suppliers

Global Suppliers ( 347)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Shanghai HC Biotech Co., Ltd 021-20227858 sale@hcbiotech.com.cn China 1173 55
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Shanghai HC Biotech Co., Ltd 55
INTATRADE GmbH 66
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid pictures 2025-04-04 L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
74163-81-8
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid pictures 2021-08-12 L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
74163-81-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid pictures 2021-07-02 (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
74163-81-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Spectrum

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid(74163-81-8)1HNMRL-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid(74163-81-8)FT-IRL-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid(74163-81-8)IR

74163-81-8 (L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid) Related Search:

2-Tetrahydrofuroic acid cis-1,2,3,6-Tetrahydrophthalic anhydride Isoquinoline-1-carboxylic acid Potassium hydrogen phthalate Tetramethylammonium hydroxide pentahydrate
Isoquinoline Tetrahydrofuran H-Tic-OMe·HCl L-tert-Leucine methyl ester hydrochloride H-Tic-OtBu·HCl
1,2,3,4-Tetrahydroquinoline 5,6,7,8-Tetrahydroisoquinoline 1,2,3,4-Tetrahydroisoquinoline H-Tle-OtBu HCl (S)-6,7-Dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
Quinapril hydrochloride Moexipril (S)-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE,L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE

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(S)-TIC (S)-N-tert-1,2,3,4-tetrahydroisoquinoline -3-carboxamide L-1,2,3,4-Tetrahydro 4-Tetrahydro-3-Isoquinolinecarboxylic acid [S]-1,2,3,4-Tetrahydro-3-Isoquinolingcarboxylic Acid (S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (for Quinapril) L-1,2,3,4-Tetrahydroisoquinoline-3-CarboxylicAcid98% (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYLESTHER (3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLICACIDHYDROCHLORIDE L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxlicacid (S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic aci L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 1,2,3,4-Tetrahydroisoquinoline-3-carboxxylic acid (S)-1,2,3,4-TERTRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID (3S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECA (S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic acid hydrochloride, 95+% (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid,97% (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Quinapril Bicyclic Acid (S)-1,2,3,4-TETRAHYDO-3-ISOQUINOLINECARBOXYLIC ACID HCL (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HCL SALT (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HCL S-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE (3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid≥ 98% (HPLC) Tic-OH (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid,99%e.e. (3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarbocylic acid for synthesis L-TIC HCL L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE 3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-,(3S)- Quinapril EP Impurity A Quinapril Impurity 1（Quinapril EP Impurity A） (3S)-1,2,3,4-Tetrahydroisoquinoline (S)-1,2,3,4-Tetrahydro-3-isoquinoL [S]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINGCARBOXYLIC ACID (CAS:74163-81-8) L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid USP/EP/BP (S)-(-) 1,2,3, 4-Tetrahydroisoquinoline -3-Carboxylic Acid pure, 98% Quinapril Hydrochloride Impurity A Quinapril Hydrochloride EP Impurity A (-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (-)-1,2,3,4-Tetrahydro-isoquinolin-3-carboxylic acid Icatibant Impurity 14 (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid 74163-81-8 Others Peptide Synthesis Unnatural Amino Acid Derivatives Specialty Synthesis Carboxylic Acids (intermediate of quinapril) Carboxylic Acids Quinolines, Isoquinolines & Quinoxalines chiral Amino Acids Chiral Reagents Heterocycles