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1,2,3,4-Tetrahydroquinoline

1,2,3,4-Tetrahydroquinoline Structure
1,2,3,4-Tetrahydroquinoline structure
CAS No.
635-46-1
Chemical Name:
1,2,3,4-Tetrahydroquinoline
Synonyms
Tetrahydroquinoline;200g;Kusol;200G/1KG/5KG;1-AZATETRALIN;AURORA KA-684;AKOS BBS-00003596;1,2,3,4-Tetrahydroqu;Py-Tetrahydroquinoline;1,2,3,4-Hydroquinoline
CBNumber:
CB7286982
Molecular Formula:
C9H11N
Molecular Weight:
133.19
MDL Number:
MFCD00006693
MOL File:
635-46-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:09:38
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1,2,3,4-Tetrahydroquinoline Properties

Melting point 9-14 °C (lit.)
Boiling point 113-117 °C/10 mmHg (lit.) 249 °C (lit.)
Density 1.061 g/mL at 25 °C (lit.)
refractive index n20/D 1.593(lit.)
Flash point 213 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Liquid
pka 5.09±0.20(Predicted)
color Clear pale yellow to yellow
PH 10-11 (111g/l, H2O, 20℃)(as an emulsion)
Odor at 1.00 % in dipropylene glycol. honey civet animal phenolic
Odor Type animal
biological source synthetic
Water Solubility <1 g/L (20 ºC)
FreezingPoint 11.0 to 20.0 ℃
BRN 116149
InChI 1S/C9H11N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-2,4,6,10H,3,5,7H2
InChIKey LBUJPTNKIBCYBY-UHFFFAOYSA-N
SMILES C1CNc2ccccc2C1
LogP 2.290
CAS DataBase Reference 635-46-1(CAS DataBase Reference)
FDA UNII CCR50N1Z9G
NIST Chemistry Reference Quinoline, 1,2,3,4-tetrahydro-(635-46-1)
EPA Substance Registry System 1,2,3,4-Tetrahydroquinoline (635-46-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H412
Precautionary statements  P264-P270-P273-P301+P310-P405-P501
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,T
Risk Statements  36/37/38-45
Safety Statements  26-36/37-36-45-53
WGK Germany  3
TSCA  TSCA listed
HS Code  29334990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Aquatic Chronic 3
REACH Registrations Active
NFPA 704
1
3 0

1,2,3,4-Tetrahydroquinoline price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 87350 1,2,3,4-Tetrahydroquinoline purum, ≥96.0% (GC) 635-46-1 500ml $98.5 2026-04-30 Buy
Sigma-Aldrich 87350 1,2,3,4-Tetrahydroquinoline purum, ≥96.0% (GC) 635-46-1 100ml $55.3 2023-06-20 Buy
TCI Chemical T0113 1,2,3,4-Tetrahydroquinoline >95.0%(GC) 635-46-1 25mL $17 2026-04-30 Buy
TCI Chemical T0113 1,2,3,4-Tetrahydroquinoline >95.0%(GC) 635-46-1 100mL $29 2026-04-30 Buy
Usbiological 290527 1,2,3,4Tetrahydroquinoline Asreported 635-46-1 250g $315 2026-06-03 Buy
Product number Packaging Price Buy
87350 500ml $98.5 Buy
87350 100ml $55.3 Buy
T0113 25mL $17 Buy
T0113 100mL $29 Buy
290527 250g $315 Buy

1,2,3,4-Tetrahydroquinoline Chemical Properties, Uses, Production

Chemical Properties

Clear pale yellow to yellow liquid. It is easily oxidized in air and may acquire a pale amber colour if exposed to air and daylight. Solidifies in the cold.

Uses

1,2,3,4-Tetrahydroquinoline is a reagent used in the synthesis of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamides displaying fungicidal activity.

Definition

ChEBI: A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.

Application

1,2,3,4-Tetrahydroquinoline (THQ) is a fundamental structural unit that can be used as a pharmaceutical intermediate. THQ and its derivatives are frequently employed in the development of numerous compounds with significant biological activity, such as anticancer drugs, chronic pain inhibitors and agents for reversing multidrug resistance.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905
Tetrahedron, 52, p. 1631, 1996 DOI: 10.1016/0040-4020(95)00991-4

Safety

1,2,3,4-Tetrahydroquinoline is harmful to humans; it can be absorbed through the skin, causing skin irritation and severe eye irritation. Inhalation may cause respiratory tract irritation. Pharmacological studies indicate that it is toxic to the central nervous system, the cornea, the retina and the optic nerve; ingestion may cause liver damage and liver cancer.

Synthesis

1,2,3,4-Tetrahydroquinoline is synthesised using quinoline N-oxide as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: In a 1.5 mL reaction vial, B(C6F5)3 (0.025 mmol, 5.0 mol %) was dissolved in chloroform (0.60 mL), towhich diethylsilane (1.75 mmol, 3.5 equiv) was added. After shaking briefly, quinolines (1a-p, 0.50 mmol, 1.0equiv) was subsequently added to the above catalyst solution under argon atmosphere. The reaction mixturewas stirred at 25-65 oC for 6-24 h for the reaction of 1a-h, and at 25-100 oC for 2-24 h for the reaction of 1i-p,then allowed to cool down to room temperature and concentrated under reduced pressure to give the crudeproduct. This reaction mixture was then treated with 0.25 N HCl ethereal solution (7 mL) and stirred at roomtemperature for 1 h to give the solid residue, which was subsequently washed with ether. The solid residue wasthen dissolved or suspended in MeOH (1.0 mL) and neutralized with Na2CO3·H2O (0.5 g) at 0 oC. After stirringfor 2 h, MeOH was removed under reduced pressure, and the neutralized reaction residue was dissolved inCH2Cl2 and washed with brine (5 mL) and water (5 mL). The crude product was then obtained from the organicphase of CH2Cl2 solution and finally purified by column chromatography on silica gel to give 2a-h(EtOAc/Hexane = 1/9) and 2i-p (EtOAc/Hexane = 3/7).
1,2,3,4-Tetrahydroquinoline synthesis

1,2,3,4-Tetrahydroquinoline Preparation Products And Raw materials

Raw materials

Quinoline Ethylene glycol

Preparation Products

6-Bromoquinoline 7-Amino-1-methyl-1,2,3,4-tetrahydroquinoline 1,2,3,4-Tetrahydro-8-hydroxyquinoline Lilolidine 7-Nitro-quinoline
4-Thiazolecarboxylic acid 1-Piperidinecarboxylic acid, 4-(3,4-dihydro-1(2H)-quinolinyl)-, 1,1-dimethylethyl ester Quinoline, 8-ethyl-1,2,3,4-tetrahydro- 6-iodo-1,2,3,4-tetrahydroquinoline 7-Hydroxy-5-oxo-N-propyl-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxamide

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1,2,3,4-Tetrahydroquinoline Suppliers

Global Suppliers ( 445)
Supplier Tel Email Country ProdList Advantage
Hangzhou Great Forest Biomedical Ltd. 0571-28313180 17767135330 info@great-forest.com China 55 58
Anhui Qiushi Medical Technology Co., Ltd 15005516438 sales1@qiushipharm.com China 51 58
Handan Huajun Chemicals Co., Ltd. 13303008150; 13303008150 884971191@qq.com China 20 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Hangzhou Great Forest Biomedical Ltd. 58
Anhui Qiushi Medical Technology Co., Ltd 58
Handan Huajun Chemicals Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
future industrial shanghai co., ltd 65
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81

Related articles

View Latest Price from 1,2,3,4-Tetrahydroquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3,4-Tetrahydroquinoline pictures 2026-09-18 1,2,3,4-Tetrahydroquinoline
635-46-1
 1KG 98%min GC 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
1,2,3,4-Tetrahydroquinoline pictures 2026-08-20 1,2,3,4-Tetrahydroquinoline
635-46-1
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
1,2,3,4-Tetrahydroquinoline pictures 2025-04-04 1,2,3,4-Tetrahydroquinoline
635-46-1
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

1,2,3,4-Tetrahydroquinoline Spectrum

1,2,3,4-Tetrahydroquinoline(635-46-1)MS1,2,3,4-Tetrahydroquinoline(635-46-1)1HNMR1,2,3,4-Tetrahydroquinoline(635-46-1)13CNMR1,2,3,4-Tetrahydroquinoline(635-46-1)IR11,2,3,4-Tetrahydroquinoline(635-46-1)Raman

635-46-1 (1,2,3,4-Tetrahydroquinoline) Related Search:

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Quinoline sulphate 6-FLUORO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE 99,6-FLUORO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE 99 Coumarin 153 1,2,3,4-Tetrahydroquinaldine Julolidine
CALYCANTHINE Coumarin 339 6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE (6-HQ),6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE (6-HQ) Sulforhodamine 101 3,4-Dihydroquinolin-2(1H)-one
6-Methyl-1,2,3,4-tetrahydroquinoline 8-Hydroxyjulolidine Coumarin 102

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Py-Tetrahydroquinoline 1,2,3,4-TETRAHYDROQUINOLINE FOR SYNTHESI 1,2,3,4-Tetrahydroqu 1,2,3,4-Tetrahydroquinoline, 98% 100GR 200G/1KG/5KG 1,2,3,4-Tetrahydrochinoline 1,2,3,4-tetrahydro-quinolin Kusol 1,2,3,4- fourhydrogenation ofquinoline 1,2,3,4-Tetrahydroquinoline puruM, >=96.0% (GC) 1,2,3,4-Tetrahydroquinoline, 95+% 1-AZATETRALIN 1,2,3,4-TETRAHYDROQUINOLINE 1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE AURORA KA-684 AKOS BBS-00003596 1 2 3 4-TETRAHYDROQUINOLINE 98+% 1,2,3,4-Tetrahydroquinoline99% Quinoline,1,2,3,4-tetrahydro- 1,2,3,4-Hydroquinoline 1,2,3,4-TETRHYDROQUINOLINE 1,2,3,4-TetrahydroquinoL 1,2,3,4-Tetrahydroquinoline Solution 1,2,3,4-Tetrahydroquinoline > 1.2.3.4-TETRA-HYDROQUINOLINE [635-46-1 ] 1,2,3,4-Tetrahydroquinoline ISO 9001：2015 REACH 1,2,3,4-Tetrahydroquinoline Solution in Methanol 200g Tetrahydroquinoline 635-46-1 635-64-1 635-45-1 Building Blocks AMINE Isoquinolines Heterocyclic Building Blocks Quinolines Building Blocks Chemical Synthesis Heterocyclic Building Blocks Alphabetical Listings Flavors and Fragrances Q-Z Quinoline&Isoquinoline Pyridines Building Blocks Heterocyclic Building Blocks Isoquinolines Quinolines bc0001