TRIACSIN C
- CAS No.
- 76896-80-5
- Chemical Name:
- TRIACSIN C
- Synonyms
- WS1228A;FR-900190;TRIACSIN C;2,4,7-Undecatrienal;Triacsincapprox.90%;Antibiotic WS-1228A;Antibiotic FR-900190;Triacsin C, lyophilized;Triacsin C Solution in DMSO;from Streptomyces aureofaciens
- CBNumber:
- CB0199054
- Molecular Formula:
- C11H17N3O
- Molecular Weight:
- 207.27
- MDL Number:
- MFCD00798237
- MOL File:
- 76896-80-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 320.7±45.0 °C(Predicted) |
|---|---|
| Density | 0.94±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | methanol: soluble4.90 - 5.10 mg/mL, clear (Pale yellow to yellow) |
| form | Liquid. In DMSO. |
| pka | -0.10±0.70(Predicted) |
| color | clear (Pale yellow to yellow) Solution in DMSO |
| biological source | Streptomyces sp. |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions further diluted with DMSO may be stored at -20° for up to 2 months. |
| InChI | 1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+ |
| InChIKey | NKTGCVUIESDXPU-YLEPRARLSA-N |
| SMILES | CCC\C=C\C\C=C\C=C\C=N\NN=O |
| FDA UNII | 6M6D4602I5 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280 |
| WGK Germany | 3 |
| HS Code | 29299090 |
| Storage Class | 11 - Combustible Solids |
TRIACSIN C price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T4540 | Triacsin C from Streptomyces sp. | 76896-80-5 | 1mg | $1220 | 2026-04-30 | Buy |
| Cayman Chemical | 10007448 | Triacsin C ≥95% | 76896-80-5 | 500μg | $329 | 2026-04-30 | Buy |
| Cayman Chemical | 10007448 | Triacsin C ≥95% | 76896-80-5 | 1mg | $592 | 2026-04-30 | Buy |
| Usbiological | 256968 | Triacsin C ≥95% | 76896-80-5 | 500ug | $672 | 2026-06-03 | Buy |
| Usbiological | 256968 | Triacsin C ≥95% | 76896-80-5 | 1mg | $1118 | 2026-06-03 | Buy |
TRIACSIN C Chemical Properties,Uses,Production
Description
Triacsin C (76896-80-5) is a long-chain fatty acyl CoA synthetase inhibitor (IC50=3.6-8.7 μM).1Inhibits mouse macrophage-derived foam cell formation2 and displays anti-atherosclerotic activity3. Cell permeable.
Chemical Properties
Solid
Uses
Triacsin, a fatty acyl CoA synthetase inhibitor, reduces myocardial infarct size, attenuates loss of post-reperfusion cardiac function, increases intravascular nitric oxide (NO) concentration, and inhibits leukocyte recruitment. Triacsin C analogs can also be used as potential antivirals against rotavirus infections.
Definition
ChEBI: Triacsin C is a nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters. It has a role as an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a vasodilator agent, an apoptosis inhibitor, a bacterial metabolite, an EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor and an antimalarial. It is a nitroso compound, an olefinic compound and a hydrazone.
General Description
Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus.
Biochem/physiol Actions
Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.
storage
Store at -20°C
References
[1] E.J. HARTMAN M. L S Omura ∗. Triacsin C: A differential inhibitor of arachidonoyl-CoA synthetase and nospecific long chain acyl-CoA synthetase,[J]. Prostaglandins, 1989, 37 6: Pages 655-671. DOI:10.1016/0090-6980(89)90103-2
[2] I NAMATAME. Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C.[J]. Journal of biochemistry, 1999, 125 2: 319-327. DOI:10.1093/oxfordjournals.jbchem.a022289
[3] DAISUKE MATSUDA. Anti-atherosclerotic Activity of Triacsin C, an Acyl-CoA Synthetase Inhibitor[J]. Journal of Antibiotics, 2008, 61 5: 318-321. DOI:10.1038/ja.2008.45
TRIACSIN C Preparation Products And Raw materials
Raw materials
Preparation Products
TRIACSIN C Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3057 | 58 |
View Lastest Price from TRIACSIN C manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | TRIACSIN C
76896-80-5
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-26 | Triacsin C
76896-80-5
|
$470.00 | 10g | TargetMol Chemicals Inc. |
-
- TRIACSIN C
76896-80-5
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Triacsin C
76896-80-5
- $470.00
- TargetMol Chemicals Inc.
