MYRIOCIN
- CAS No.
- 35891-70-4
- Chemical Name:
- MYRIOCIN
- Synonyms
- ISP-1;ISP-I;C001996;MYRIOCIN;6e))-4s*;NSC 177379;THERMOZYMOCIDIN;Spi-1 inhibitor;Myriocin (ISP-1);Isp-1 suppressant
- CBNumber:
- CB0207522
- Molecular Formula:
- C21H39NO6
- Molecular Weight:
- 401.54
- MDL Number:
- MFCD01632772
- MOL File:
- 35891-70-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Myriocin from Mycelia sterilia ≥98% (HPLC), powder | M1177 | 5mg | $93.5 |
| Myriocin from Mycelia sterilia A potent immunosuppressant. | 476300 | 5mg | $184 |
| Myriocin ≥95% | 63150 | 1mg | $39 |
| Myriocin ≥95% | 63150 | 5mg | $87 |
| Myriocin ≥95% | 63150 | 10mg | $115 |
| More product size | |||
| Melting point | 170-172℃ |
|---|---|
| Boiling point | 636.7±55.0 °C(Predicted) |
| Density | 1.123±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | methanol: 2 mg/mL |
| form | powder |
| pka | 1.79±0.50(Predicted) |
| color | off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
| InChIKey | ZZIKIHCNFWXKDY-XFXZXTDPSA-N |
| SMILES | N[C@]([C@@H](O)[C@H](O)C\C=C\CCCCCCC(=O)CCCCCC)(CO)C(=O)O |
| CAS DataBase Reference | 35891-70-4 |
| FDA UNII | YRM4E8R9ST |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JX3890000 | |||||||||
| HS Code | 29225090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
MYRIOCIN price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M1177 | Myriocin from Mycelia sterilia ≥98% (HPLC), powder | 35891-70-4 | 5mg | $93.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 476300 | Myriocin from Mycelia sterilia A potent immunosuppressant. | 35891-70-4 | 5mg | $184 | 2026-04-30 | Buy |
| Cayman Chemical | 63150 | Myriocin ≥95% | 35891-70-4 | 1mg | $39 | 2026-04-30 | Buy |
| Cayman Chemical | 63150 | Myriocin ≥95% | 35891-70-4 | 5mg | $87 | 2026-04-30 | Buy |
| Cayman Chemical | 63150 | Myriocin ≥95% | 35891-70-4 | 10mg | $115 | 2026-04-30 | Buy |
MYRIOCIN Chemical Properties,Uses,Production
Description
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10-
Chemical Properties
White powder
Uses
Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin i s a useful biochemical research tool for depleting cells of sphingolipids.
Uses
Myriocin is an α-amino fatty acid derived from several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin potently inhibits sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depleting cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant.
Uses
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.[Cayman Chemical]
Definition
ChEBI: An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
General Description
A potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
Biochem/physiol Actions
Product does not compete with ATP.
References
[1] T FUJITA. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.[J]. Journal of Antibiotics, 1994, 47 2: 208-215. DOI:10.7164/antibiotics.47.208
[2] MIYAKE Y. Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin[J]. Biochemical and biophysical research communications, 1995, 211 2: Pages 396-403. DOI:10.1006/bbrc.1995.1827
[3] YOUN-SUN LEE. Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis.[J]. Cancer Biology & Therapy, 2012, 13 2: 92-100. DOI:10.4161/cbt.13.2.18870
MYRIOCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57473 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40048 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29970 | 65 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
