Phenoxyacetyl chloride
- CAS No.
- 701-99-5
- Chemical Name:
- Phenoxyacetyl chloride
- Synonyms
- SKL1266;AKOS BBS-00003927;Acyl chloride kind;Phenoxyacetyl chlori;phenoxy-acetylchlorid;PHENOXYACETYL CHLORIDE;LABOTEST-BB LT00643586;Acetylchloride,phenoxy-;Phenyloxyacetyl chloride;PhenoxyacetylChloride>
- CBNumber:
- CB0227245
- Molecular Formula:
- C8H7ClO2
- Molecular Weight:
- 170.59
- MDL Number:
- MFCD00000726
- MOL File:
- 701-99-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 100-100.5 °C |
|---|---|
| Boiling point | 225-226 °C (lit.) |
| Density | 1.235 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 227 °F |
| storage temp. | Store at RT. |
| form | Liquid |
| color | Clear slightly yellow to brown |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 607585 |
| InChI | InChI=1S/C8H7ClO2/c9-8(10)6-11-7-4-2-1-3-5-7/h1-5H,6H2 |
| InChIKey | PKUPAJQAJXVUEK-UHFFFAOYSA-N |
| SMILES | C(Cl)(COC1=CC=CC=C1)=O |
| CAS DataBase Reference | 701-99-5(CAS DataBase Reference) |
| FDA UNII | NS65CKB849 |
| NIST Chemistry Reference | Acetyl chloride, phenoxy-(701-99-5) |
| EPA Substance Registry System | Acetyl chloride, phenoxy- (701-99-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H335 | |||||||||
| Precautionary statements | P261-P271-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 14-34-36/37 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-19 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29189090 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B STOT SE 3 |
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| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Phenoxyacetyl chloride price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 158623 | Phenoxyacetyl chloride 98% | 701-99-5 | 10g | $56.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 158623 | Phenoxyacetyl chloride 98% | 701-99-5 | 50g | $162 | 2026-04-30 | Buy |
| TCI Chemical | P0113 | Phenoxyacetyl Chloride >98.0%(GC)(T) | 701-99-5 | 25g | $31 | 2026-04-30 | Buy |
| TCI Chemical | P0113 | Phenoxyacetyl Chloride >98.0%(GC)(T) | 701-99-5 | 500g | $356 | 2026-04-30 | Buy |
| Ambeed | A950387 | 2-Phenoxyacetyl chloride 98% | 701-99-5 | 5g | $22 | 2026-06-05 | Buy |
Phenoxyacetyl chloride Chemical Properties, Uses, Production
Chemical Properties
Colorless to brown liquid
Uses
Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.
Uses
Phenoxyacetyl chloride was used in the synthesis of:
- series of macrocyclic bis-β-lactams
- 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester
- N-protected guanosine derivatives, useful in RNA synthesis
- phenyloxyketene, for cycloaddition to imines leading to β-lactams
Purification Methods
If it has no OH band in the IR then distil it in a vacuum, taking precautions for the moisture-sensitive compound. If it contains free acid (due to hydrolysis, OH bands in the IR), then add an equal volume of redistilled SOCl2, reflux for 2-3hours, evaporate and distil the residue in a vacuum as before. The amide has m 101o. [McElvain & Carney J Am Chem Soc 68 2592 1946, Beilstein 6 III 613.]
Phenoxyacetyl chloride Preparation Products And Raw materials
Phenoxyacetyl chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qujing Zhanyi Quanda Chemical Co., Ltd. | 13267170933 | China | 11 | 58 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
View Latest Price from Phenoxyacetyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Phenoxyacetyl chloride
701-99-5
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2021-08-12 | Phenoxyacetyl chloride
701-99-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-02 | Phenoxyacetyl Chloride
701-99-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Phenoxyacetyl chloride
701-99-5
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Phenoxyacetyl chloride
701-99-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Phenoxyacetyl Chloride
701-99-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
