3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide
- CAS No.
- 6869-66-5
- Chemical Name:
- 3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide
- Synonyms
- Cinobufagone;3-Oxocinobufagin;3-Ketocinobufagin;3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide;16β-Acetyloxy-14,15β-epoxy-3-oxo-5β-bufa-20,22-dienolide
- CBNumber:
- CB02275796
- Molecular Formula:
- C26H32O6
- Molecular Weight:
- 440.52868
- MDL Number:
- MOL File:
- 6869-66-5.mol
3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide Chemical Properties, Uses, Production
Uses
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL)[1].
References
[1] He X, Tang J, Qiao A, et al. Cytotoxic biotransformed products from cinobufagin by Mucor spinosus and Aspergillus Niger[J]. Steroids, 2006, 71(5): 392-402.
3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide Preparation Products And Raw materials
Raw materials
Preparation Products
3-Oxo-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yanchun Biopharmaceutical Technology Co., Ltd | 4001-009266 17349750668 | product@sci-e.com | China | 2808 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 10763 | 58 |
| Chengdu DeSiTe Biological Technology Co., Ltd | 17308096051 17308096051 | 3001048290@qq.com | China | 4211 | 58 |
